α-Lipoic Acid

By Targets:	Akt (1) Apoptosis (5) Biochemical Assay Reagents (2) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (9) GLUT (1) HIV (5) Insulin Receptor (1) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (9) NF-κB (5) NO Synthase (1) PROTAC Linkers (1) Reactive Oxygen Species (ROS) (4) Reference Standards (4) TrxR (1) Tyrosinase (1)
By Research Areas:	Cancer (11) Infection (5) Inflammation/Immunology (10) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-N0492

α-Lipoic Acid Maximum Cited Publications 14 Publications Verification Thioctic Acid; (±)-α-Lipoic Acid; DL-α-Lipoic Acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium Maximum Cited Publications 14 Publications Verification Thioctic Acid sodium; (±)-α-Lipoic Acid sodium; DL-α-Lipoic Acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-18733

Lipoic acid 5+ Cited Publications (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Endogenous Metabolite Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Inflammation/Immunology Cancer
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N0492S

α-Lipoic Acid-d5 Thioctic Acid-d₅; (±)-α-Lipoic Acid-d₅; DL-α-Lipoic Acid-d₅	Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells .

HY-134633

Alpha-lipoic acid choline ester chloride EV 06 chloride; UNR 844 chloride	Drug Intermediate	Neurological Disease
Alpha-lipoic acid choline ester (EV 06) chloride is choline ester of alpha-lipoic acid. Alpha-lipoic acid choline ester chloride reduces the disulfide bond level of lens proteins. Alpha-lipoic acid choline ester chloride improves lens elasticity. Alpha-lipoic acid choline ester chloride is hydrolyzed by ocular esterases to release alpha-lipoic acid and choline. Alpha-lipoic acid choline ester chloride is used for the research of presbyopia .

HY-141336

α-Lipoic acid-NHS 3 Publications Verification DL-α-Lipoic Acid-NHS	PROTAC Linkers	Cancer
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W015777

4-Methoxybenzyl alcohol P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol	Biochemical Assay Reagents	Others
4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

HY-119152

CMX-2043	Insulin Receptor Tyrosinase Akt	Others
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model .

HY-N0492R

α-Lipoic Acid (Standard) Maximum Cited Publications 14 Publications Verification Thioctic Acid (Standard); (±)-α-Lipoic Acid (Standard); DL-α-Lipoic Acid (Standard)	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-18733R

Lipoic acid (Standard) 5+ Cited Publications (R)-(+)-α-Lipoic Acid(Standard); R-(+)-Thioctic Acid (Standard)	Reference Standards Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-151802

CPUL1	TrxR	Cancer
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective .

HY-N0492AR

α-Lipoic Acid sodium (Standard) Thioctic Acid sodium (Standard); (±)-α-Lipoic Acid sodium (Standard); DL-α-Lipoic Acid sodium (Standard)	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

HY-120974

α-lipoic acid derivative 1	GLUT	Metabolic Disease
α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes .

HY-18733S

Lipoic acid-d4 (R)-(+)-α-Lipoic Acid-d₄; R-(+)-Thioctic Acid-d₄	Isotope-Labeled Compounds Endogenous Metabolite Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lipoic acid-d₄ ((R)-(+)-α-Lipoic acid-d₄) is deuterium labeled Lipoic acid. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid .

HY-W015777R

4-Methoxybenzyl alcohol (Standard) P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)	Reference Standards Biochemical Assay Reagents	Others
4-Methoxybenzyl alcohol (Standard) is the analytical standard of 4-Methoxybenzyl alcohol. This product is intended for research and analytical applications. 4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

HY-18733G

Lipoic acid (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Reactive Oxygen Species (ROS) Mitochondrial Metabolism Endogenous Metabolite	Inflammation/Immunology Cancer
Lipoic acid (GMP) ((R)-(+)-α-Lipoic acid (GMP)) is Lipoic acid (HY-18733) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-183808

N-(1,2-Dithiolane-3-pentanoyl)-Glu-Ala	Drug Derivative	Inflammation/Immunology
N-(1,2-Dithiolane-3-pentanoyl)-Glu-Ala is a derivative of DL-α-lipoic acid (HY-N0492). N-(1,2-Dithiolane-3-pentanoyl)-Glu-Ala can be used for the research of ischemic and ischemia-reperfusion injuries .

HY-W839206

NOS-IN-4	NO Synthase	Neurological Disease
NOS-IN-4 (Compound 3) is a neuronal nitric oxide synthase (nNOS) inhibitor with an IC₅₀ of 4.00 μM that inhibits nNOS activity. The combined use of alpha-lipoic acid and NOS-IN-4 has a protective effect against MPTP (HY-W114750)-induced dopamine depletion in the mouse brain. NOS-IN-4 can be used for the research of neurological disease .

Cat. No.	상품명	Type

HY-18733G

Lipoic acid (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Fluorescent Dyes
Lipoic acid (GMP) ((R)-(+)-α-Lipoic acid (GMP)) is Lipoic acid (HY-18733) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

Lipoic acid

(R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid

Fluorescent Dyes

Lipoic acid (GMP) ((R)-(+)-α-Lipoic acid (GMP)) is Lipoic acid (HY-18733) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

Cat. No.	상품명	Type

HY-W015777

4-Methoxybenzyl alcohol P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol	Biochemical Assay Reagents
4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

HY-W015777R

4-Methoxybenzyl alcohol (Standard) P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)	Biochemical Assay Reagents
4-Methoxybenzyl alcohol (Standard) is the analytical standard of 4-Methoxybenzyl alcohol. This product is intended for research and analytical applications. 4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

4-Methoxybenzyl alcohol (Standard)

P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)

Biochemical Assay Reagents

4-Methoxybenzyl alcohol (Standard) is the analytical standard of 4-Methoxybenzyl alcohol. This product is intended for research and analytical applications. 4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

HY-18733G

Lipoic acid (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Biochemical Assay Reagents
Lipoic acid (GMP) ((R)-(+)-α-Lipoic acid (GMP)) is Lipoic acid (HY-18733) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

Lipoic acid

(R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid

Biochemical Assay Reagents

Lipoic acid (GMP) ((R)-(+)-α-Lipoic acid (GMP)) is Lipoic acid (HY-18733) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

Cat. No.	상품명	Target	Research Area

HY-119152

CMX-2043	Insulin Receptor Tyrosinase Akt	Others
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N0492

α-Lipoic Acid Maximum Cited Publications 14 Publications Verification Thioctic Acid; (±)-α-Lipoic Acid; DL-α-Lipoic Acid	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium Maximum Cited Publications 14 Publications Verification Thioctic Acid sodium; (±)-α-Lipoic Acid sodium; DL-α-Lipoic Acid sodium	Infection Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-18733

Lipoic acid 5+ Cited Publications (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Reactive Oxygen Species (ROS) Mitochondrial Metabolism
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N0492R

α-Lipoic Acid (Standard) Maximum Cited Publications 14 Publications Verification Thioctic Acid (Standard); (±)-α-Lipoic Acid (Standard); DL-α-Lipoic Acid (Standard)	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-18733R

Lipoic acid (Standard) 5+ Cited Publications (R)-(+)-α-Lipoic Acid(Standard); R-(+)-Thioctic Acid (Standard)	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Reference Standards Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species (ROS)
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N0492AR

α-Lipoic Acid sodium (Standard) Thioctic Acid sodium (Standard); (±)-α-Lipoic Acid sodium (Standard); DL-α-Lipoic Acid sodium (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

Cat. No.	상품명	Chemical Structure

HY-N0492S

α-Lipoic Acid-d5
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells .

HY-18733S

Lipoic acid-d4
Lipoic acid-d₄ ((R)-(+)-α-Lipoic acid-d₄) is deuterium labeled Lipoic acid. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid .

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-18733G

Lipoic acid (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Reactive Oxygen Species (ROS) Mitochondrial Metabolism Endogenous Metabolite	Inflammation/Immunology Cancer
Lipoic acid (GMP) ((R)-(+)-α-Lipoic acid (GMP)) is Lipoic acid (HY-18733) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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비고

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

α-Lipoic Acid

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

GMP Molecules

Natural
Products