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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
β-amyloid plaques
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "β-amyloid plaques" in MCE Product Catalog:
11
11 Publications Verification
Cat. No.: HY-P0265A
Synonyms: amyloid β-Peptide (1-40) (human) TFA; Aβ40 (human) TFA; Aβ(1-40) (human) TFA
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11
11 Publications Verification
Cat. No.: HY-P0265C
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1
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Umibecestat (CNP520) is a selective, orally active BACE inhibitor, with an IC50 of 11 nM for hBACE-1, 10 nM for mouse BACE-1, and 30 nM for hBACE-2. Umibecestat reduces β-Amyloid levels in the brain and cerebrospinal fluid, decreases β-amyloid plaque deposition, and inhibits plaque-associated neuroinflammation. Umibecestat is used in research related to Alzheimer's disease .
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1 Cited Publications
Cat. No.: HY-P1206
CAS No.: 174688-78-9
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CH 275 is a peptidic somatostatin analog that acts as an agonist of SST1 (IC50 = 30.9 nM, Ki = 52 nM). The IC50 values of CH 275 for sst3, sst4, sst2, and sst5 are 345 nM, >1 μM, >10 μM, and >10 μM, respectively. CH 275 binds to SSTR1 via the IAmp9-Asp137 ion pair interaction and the hydrophobic interaction between the isopropyl group of IAmp9 and Leu107, and reduces the extracellular acidification rate. CH 275 induces weak sst1 internalization, exerts immunosuppressive effects on macrophages, and decreases macrophage viability, MCP-1 expression/secretion, and IL-8 secretion, but does not alter proMMP-9 secretion or IL-8 mRNA levels. CH 275 reduces hippocampal β-amyloid levels and alleviates plaque pathology without inducing hippocampal microglial activation. CH 275 is used in research on Alzheimer's disease, Parkinson's disease, and depression .
Cat. No.: HY-P1466
CAS No.: 131580-10-4
Synonyms: amyloid β-Protein (1-16)
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Cat. No.: HY-P1046
CAS No.: 183745-81-5
Synonyms: amyloid β-Protein (1-15)
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Cat. No.: HY-P1387
CAS No.: 144409-98-3
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Cat. No.: HY-P1468
CAS No.: 109770-29-8
Synonyms: amyloid β-Protein (1-28)
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Cat. No.: HY-P3780
CAS No.: 1802078-25-6
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Cat. No.: HY-P0265AS
Synonyms: amyloid Beta-Peptide-15N (1-40) (human) TFA; amyloid β-Peptide-15N (1-40) (human) TFA
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Cat. No.: HY-P1051
CAS No.: 107015-83-8
Synonyms: amyloid β-Protein (12-28)
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Cat. No.: HY-P2562
CAS No.: 186359-66-0
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Cat. No.: HY-152110
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Dual AChE-MAO B-IN-5, indanone derivative, is a potent dual AChE/MAO-B inhibitior with IC50 values of 0.0224, 0.0412, and 0.1116 μM for AChE, MAO-B and MAO-A, respectively. Dual AChE-MAO B-IN-5 has antioxidant activity and prevents β-amyloid plaque aggregation. Dual AChE-MAO B-IN-5 can be used for Alzheimer’s disease (AD) research .
Cat. No.: HY-P1051A
Synonyms: amyloid β-Protein (12-28) TFA; amyloid Beta-Peptide (12-28) (human) TFA; β-amyloid protein fragment(12-28) TFA
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Cat. No.: HY-P1567
CAS No.: 181427-66-7
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Cat. No.: HY-167898
CAS No.: 955376-42-8
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MeS-IMPY is a ligand of β-amyloid plaques. MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (Ki=7.93 and 8.95 nM, respectively). [ 11C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET) .
Cat. No.: HY-D1684
CAS No.: 125113-96-4
Cat. No.: HY-P10824
CAS No.: 1430219-69-4
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Cat. No.: HY-152114
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AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0393 μM for human MAO-B. AChE/BChE/MAO-B-IN-4 is a potent AChE and BChE enzyme inhibitor, with IC50s of 0.0458 μM and 0.075 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-4 shows significant antioxidant activity and prevent β-amyloid plaque aggregation. AChE/BChE/MAO-B-IN-4 has the potential for Alzheimer's disease (AD) research .
Cat. No.: HY-119689A
CAS No.: 2365306-62-1
Synonyms: CNP520 hydrochloride
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Umibecestat hydrochloride (CNP520 hydrochloride) is a selective, orally active BACE inhibitor, with an IC50 of 11 nM for hBACE-1, 10 nM for mouse BACE-1, and 30 nM for hBACE-2. Umibecestat hydrochloride reduces β-Amyloid levels in the brain and cerebrospinal fluid, decreases β-amyloid plaque deposition, and inhibits plaque-associated neuroinflammation. Umibecestat hydrochloride is used in research related to Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
