AChE/MAO-IN-2
Dual AChE-MAO B-IN-5, indanone derivative, is a potent dual AChE/MAO-B inhibitior with IC50 values of 0.0224, 0.0412, and 0.1116 μM for AChE, MAO-B and MAO-A, respectively. Dual AChE-MAO B-IN-5 has antioxidant activity and prevents β-amyloid plaque aggregation. Dual AChE-MAO B-IN-5 can be used for Alzheimer’s disease (AD) research.
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- Formule: C23H26N2O3
- Masse moléculaire:378.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
AChE 0.0224 μM (IC50) |
MAO-B 0.0412 μM (IC50) |
MAO-A 0.1116 μM (IC50) |
In Vitro
Dual AChE-MAO B-IN-5 (conpound D29; 0.1-1 μM) has antioxidant activity with an IC50 value of 0.188 μM[1].
Dual AChE-MAO B-IN-5 (0.1-1 μM) increases cholinergic activity and prevents the buildup of β-amyloid plaque with inhibitions of 82.748% and 71.891 % for 0.1 μM and 1 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 378.46
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Formule C23H26N2O3
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SMILES
O=C(NC1=CC=C(/C=C(CC2=C3C=C(OC)C=C2)/C3=O)C=C1)CN(C)CCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/MAO-IN-2 Related Classifications
HY-152110 Related Classifications
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