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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
3-hydroxy-3-methylglutaryl-coenzyme A reductase
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "3-hydroxy-3-methylglutaryl-coenzyme A reductase" in MCE Product Catalog:
73
73 Publications Verification
Cat. No.: HY-17379
CAS No.: 134523-03-8
Synonyms: CI-981; Atorvastatin hemicalcium
Research Areas:
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, with blood-brain barrier permeability. Atorvastatin hemicalcium salt has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively .
7
Research Areas:
SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM . SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) .
2
2 Cited Publications
Cat. No.: HY-P72228
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGCR; 3-hydroxy-3-methylglutaryl coenzyme A reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; hydroxymethylglutaryl-CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Alternative Protein HMGCR; HMG-CoA reductase; LGMDR28; 3-Hydrox
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P81197
Synonyms: 3 hydroxy 3 methylglutaryl CoA reductase antibody;
3 hydroxy 3 methylglutaryl coenzyme A reductase antibody;
3 hydroxymethylglutaryl CoA reductase antibody;
3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody;
3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody;
3H3M antibody;
HMDH_HUMAN antibody;
HMG CoA reductase antibody;
HMG CoAR antibody;
HMG-CoA reductase antibody;
Hmgcr antibody;
hydroxymethylglutaryl CoA reductase antibody;
LDLCQ3 antibody;
MGC103269 antibody;
Red antibody;
Synonyms: HMG-CoA disodium hydrate
Research Areas:
2-Hydroxy atorvastatin calcium salt is an orally active OATP1B1 substrate and inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase). 2-Hydroxy atorvastatin calcium salt enters cells via OATP1B1-mediated cellular uptake and inhibits de novo hepatic cholesterol synthesis. As an active metabolite of Atorvastatin (HY-B0589), 2-Hydroxy atorvastatin calcium salt contributes to the inhibitory activity against plasma HMG-CoA reductase. 2-Hydroxy atorvastatin calcium salt can be biotransformed into an inactive lactone form, which can be hydrolyzed back to its active acid form chemically or enzymatically. 2-Hydroxy atorvastatin (calcium salt) can be used in the research of hypercholesterolemia .
Cat. No.: HY-139951S
Cat. No.: HY-122439
CAS No.: 75225-51-3
Synonyms: Mevinolinic acid; MSD803
Cat. No.: HY-17379R
CAS No.: 134523-03-8
Synonyms: CI-981 (Standard); Atorvastatin hemicalcium (Standard)
Research Areas:
Atorvastatin (hemicalcium salt) (Standard) is the analytical standard of Atorvastatin (hemicalcium salt). This product is intended for research and analytical applications. Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively .
Cat. No.: HY-106380
CAS No.: 122254-45-9
Synonyms: HR 780
Target:
Research Areas:
Glenvastatin (HR 780) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Glenvastatin can reduces plasma total cholesterol and phospholipid levels and liver cholesterol contents. Glenvastatin does not increase the contents of cholesterol and total bile acid in the gallbladder bile. Glenvastatin can be used for the research of hyperlipemia
Cat. No.: HY-135373
CAS No.: 433289-84-0
Target:
Research Areas:
Desfluoro-atorvastatin is an impurity of Atorvastatin . Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids .
Cat. No.: HY-P706182
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGCR; 3-hydroxy-3-methylglutaryl coenzyme A reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; hydroxymethylglutaryl-CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Alternative Protein HMGCR; HMG-CoA reductase; LGMDR28; 3-Hydrox
Species:
Human
Source:
E. coli
Cat. No.: HY-N15097
CAS No.: 78366-44-6
Category:
Target:
Cat. No.: HY-117581
CAS No.: 130468-11-0
Synonyms: 6-Oxo Simvastatin; Iso-simvastatin-6-one
Target:
Research Areas:
L-669,262, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC50 of 0.10 ng/mL for rat liver HMG-CoA .
Cat. No.: HY-135375
CAS No.: 887196-29-4
Target:
Research Areas:
O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids .
Cat. No.: HY-P81197A
Synonyms: 3 hydroxy 3 methylglutaryl CoA reductase antibody;
3 hydroxy 3 methylglutaryl coenzyme A reductase antibody;
3 hydroxymethylglutaryl CoA reductase antibody;
3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody;
3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody;
3H3M antibody;
HMDH_HUMAN antibody;
HMG CoA reductase antibody;
HMG CoAR antibody;
HMG-CoA reductase antibody;
Hmgcr antibody;
hydroxymethylglutaryl CoA reductase antibody;
LDLCQ3 antibody;
MGC103269 antibody;
Red antibody;
Cat. No.: HY-100793R
CAS No.: 126411-39-0
Synonyms: GW 485801 (Standard)
Research Areas:
SR12813 (Standard) is the analytical standard of SR12813 (HY-100793). This product is intended for research and analytical applications. SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM . SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) .
Cat. No.: HY-P87294
Synonyms: 3 hydroxy 3 methylglutaryl coenzyme A synthase 1 (soluble) antibody; 3-hydroxy-3-methylglutaryl coenzyme A synthase antibody; cytoplasmic antibody; EC 2.3.3.10 antibody; HMCS1_HUMAN antibody; HMG CoA synthase antibody; HMG-CoA synthase antibody; HMGCS antibody; HMGCS1 antibody; hydroxymethylglutaryl CoA synthase, cytoplasmic antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
