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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
4′‐BR
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "4′‐BR" in MCE Product Catalog:
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1 Cited Publications
Cat. No.: HY-W007803
CAS No.: 164365-88-2
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Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
Synonyms: 4′‐BR
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4'-Bromo-resveratrol (4′‐BR) is a dual SIRT1/SIRT3 inhibitor with an IC50 of 0.2 mM for both targets. 4'-Bromo-resveratrol induces caspase-dependent apoptosis, induces G0/G1 cell cycle arrest, and inhiibits proliferation. 4'-Bromo-resveratrol reduces lactate production, glucose uptake, and NAD +/NADH ratio, and downregulates lactate dehydrogenase A and glucose transporter 1 (GLUT1). 4'-Bromo-resveratrol can be used for the research of melanoma .
Cat. No.: HY-W011178
CAS No.: 62129-39-9
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Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-W013726
CAS No.: 198561-04-5
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Cat. No.: HY-W039116
CAS No.: 2093536-12-8
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Thalidomide-4-Br (compound 53) is a compound with a bromodomain. Thalidomide-4-Br can be used in the research of inflammation, tumor and neurology .
Cat. No.: HY-48364
CAS No.: 1499388-70-3
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Hydrouracil-(4-Br-2,6-difluorobenzene) is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-(4-Br-2,6-difluorobenzene) can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-130161
CAS No.: 110429-45-3
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m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency . m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
Cat. No.: HY-W586315
CAS No.: 2619512-24-0
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Desamino lenalidomide-4-Br-5-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-4-Br-5-F can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W868011
CAS No.: 2438238-19-6
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Desamino lenalidomide-4-Br-6-acetonitrile is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-4-Br-6-acetonitrile can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W460227
CAS No.: 2438239-34-8
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Lenalidomide-4-Br-7-fluoro is a derivative of Lenalidomide with a flouride and bromide groups on the benzyl ring.
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4-Br-Bnlm is a selective inhibitor of glucose-regulated protein 94 (Grp94) with an EC50 value of 0.96 µM. 4-Br-Bnlm reduces the levels of mutant myocilin proteins as well as wild-type myocilin misfold in cells. 4-Br-Bnlm promotes the clearance of toxic formsof myocilin and reduces myocilin toxicity .
Cat. No.: HY-164391
CAS No.: 2545963-02-6
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Pomalidomide-C2-amide-C4-Br is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide-C2-amide-C4-Br can be used in the synthesis of PROTACs .
Cat. No.: HY-W458018
CAS No.: 2740657-30-9
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Thalidomide-4-Br,7-F is an E3 ligase activator featuring a bromine and a fluorine. E3 ligase is a protein that marks other proteins for proteolytic destruction by labeling them with ubiquitin. Both halogens may be substituted for further derivitization.
Cat. No.: HY-151190
CAS No.: 2821068-03-3
Synonyms: S1024
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cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells .
Cat. No.: HY-138486
CAS No.: 2680525-48-6
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Br-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-138372
CAS No.: 1803547-60-5
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Br-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-138450
CAS No.: 3026669-99-5
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Br-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-170384
CAS No.: 1690587-08-6
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Br-C4-NHBoc is a PROTAC linker used in the synthesis of CCW 28-3 (HY-156774) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
