40 Results for "

A17

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "A17" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P7759
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuCCL17, His; C-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine; CCL17; SCYA17; TARC
Species:  
Source:  
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Cat. No.: HY-163649
CAS No.: 2568186-47-8
Target:  

AMPK

Research Areas:  

Metabolic Disease

A17 is a bile acid analog with anti-non-alcoholic steatohepatitis (NASH) and anti-inflammatory activities. A17 reduces fatty acid (FA) uptake and promotes FA oxidation though inhibiting fatty acid translocase (Cd36) expression and activating AMPKα. A17 can be used for NASH research .
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Cat. No.: HY-P11053
CAS No.: 1140483-31-3
Target:  

HSP

Research Areas:  

Cancer

A17 peptide is a Hsp70-targeting peptide. A17 peptide binds to the ATP-binding domains of Hsp70. A17 peptide specifically inhibits the chaperone activity, thereby increasing the cells' sensitivity to apoptosis induced by chemotherapeutic agents, such as Cisplatin (HY-17394). A17 peptide can be used for anticancer chemotherapy research, such multiple myeloma .
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Cat. No.: HY-177078
CAS No.: 2925064-31-7
Research Areas:  

Cancer

Davotifan (Compound A17) is a bicyclic compound. Davotifan is an inhibitor of HIF-2α. Davotifan can be studied in research for HIF-2α-related cancer .
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Cat. No.: HY-P1341
CAS No.: 343268-91-7
Synonyms: Orexin A (17-33) (human, mouse, rat, bovine)
OXA (17-33) (Orexin A (17-33) (human, mouse, rat, bovine)) is the shortest active orexin peptide that selectively targets OX1 (EC50=8.29 nM), with 23-fold selectivity for the OX1 receptor over the OX2 receptor. The activity of OXA (17-33) depends on the Tyr17, Leu20, Asn25, His26 residues and the spatial conformation of the α-helix. OXA (17-33) activates signaling pathways involving inositol-1,4,5-trisphosphate receptor (IP3R), phospholipase D (PL-D) and choline-Sigma-1R, thereby increasing the cytoplasmic Ca 2+ level in nucleus accumbens neurons, an effect that is blocked by Sigma-1R antagonists. OXA (17-33) serves as an important biological probe for investigating the function of the OX1 receptor. OXA (17-33) can be modified via incorporation of mixed disulfide bonds of homocysteine and cysteamine, and is widely used in studies related to insomnia and narcolepsy .
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Cat. No.: HY-RS13070
Research Areas:  

Others

SLC22A17 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC22A17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-153443
CAS No.: 2380320-68-1
Target:  

CDK

Research Areas:  

Cancer

CDK4-IN-2 (A17) is a CDK4 inhibitor, with Ki and IC50 values of <10 nM. Used in cancer research .
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Cat. No.: HY-161061
CAS No.: 2377392-07-7
Target:  

Arginase

Research Areas:  

Cancer

Arginase inhibitor 7 (compound A17) is an arginase (ARG1) inhibitor, with an IC50 of 0.16 μM. Arginase inhibitor 7 has high oral bioavailability .
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Cat. No.: HY-178469
Target:  

Fungal

Research Areas:  

Infection

SDH-IN-35 (Compound A17) is a potent succinate dehydrogenase (SDH) inhibitor with antifungal activity (EC50=11.9 μM). SDH-IN-35 is promising for research of agricultural fungicide .
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Cat. No.: HY-139076
CAS No.: 2360487-93-8
Purity:  98.07%
Research Areas:  

Metabolic Disease Cancer

Menin-MLL inhibitor 19, a potent exo-aza spiro inhibitor of menin-mll interaction, example A17, extracted from patent WO2019120209A1. Menin-MLL inhibitor 19 can be used for the reseaech of various diseases, such as cancer, myelodysplastic syndrome (MDS) and diabetes .
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Cat. No.: HY-10893
CAS No.: 175739-42-1
Target:  

HIV

Research Areas:  

Infection

TNK-651 is a non-nucleoside HIV-1 reverse transcriptase inhibitor. TNK-651 exhibits inhibitory effects on both the HIV-1 SF33 strain and the NNRTI-resistant HIV-1 A17 strain. TNK-651 can be used for the study of HIV-1 infection .
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Cat. No.: HY-144260
CAS No.: 2432956-06-2
Target:  

SARS-CoV

Research Areas:  

Infection

3CPLro-IN-1 (compound A17) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC50 of 5.65 μM. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive agent target for fighting COVID-19 .
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Cat. No.: HY-173398
CAS No.: 3038464-68-2
NMDAR antagonist 5 (Compound A17) is a multi-target antagonist against NMDAR and monoamine transporters (SERTDAT and NET). NMDAR antagonist 5 shows good NMDAR antagonistic potency (IC50 = 0.3 μM) and monoamine transporter activities (SERT IC50 = 1.1 μM、DAT IC50 = 0.7 μM、NET IC50 = 2.7 μM). NMDAR antagonist 5 is highly safe and has low toxicity (hepatotoxicity and nephrotoxicity (IC50 > 100 μM); cardiotoxicity (IC50 = 24.5 μM)). NMDAR antagonist 5 has antidepressant effects and can be used in the study of depression .
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Cat. No.: HY-N12428
CAS No.: 65388-16-1
Synonyms: Caudicifolin; Fischeriana A
17-Hydroxyjolkinolide A (Caudicifolin; Fischeriana A) is an insect feeding inhibitor isolated from the roots of spurge. 17-Hydroxyjolkinolide A induces grain aversion in S. zeamais and T. castaneum adults, with EC50s of 631.9 ppm and 656.5 ppm, respectively.
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Cat. No.: HY-CE00512
Synonyms: 17-Methyldocosanoyl-coenzyme A
Research Areas:  

Metabolic Disease

17-Methyldocosanoyl-CoA (17-Methyldocosanoyl-coenzyme A) is a coenzyme A derivative.
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Cat. No.: HY-CE00517
Synonyms: 17-Methylicosanoyl-coenzyme A
Research Areas:  

Metabolic Disease

17-Methylicosanoyl-CoA (17-Methylicosanoyl-coenzyme A) is a coenzyme A derivative.
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Cat. No.: HY-CE00520
Synonyms: 17-Methylpentacosanoyl-coenzyme A
Research Areas:  

Metabolic Disease

17-Methylpentacosanoyl-CoA (17-Methylpentacosanoyl-coenzyme A) is a coenzyme A derivative.
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Cat. No.: HY-CE00523
Synonyms: 17-Methyltetracosanoyl-coenzyme A
Research Areas:  

Metabolic Disease

17-Methyltetracosanoyl-CoA (17-Methyltetracosanoyl-coenzyme A) is a coenzyme A derivative.
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Cat. No.: HY-CE00525
Synonyms: 17-Methyltricosanoyl-coenzyme A
Research Areas:  

Metabolic Disease

17-Methylhenicosanoyl-CoA (17-Methylhenicosanoyl-coenzyme A) is a coenzyme A derivative.
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Cat. No.: HY-RS13097
Research Areas:  

Others

SLC25A17 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC25A17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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