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Results for "

ADAMTS-4

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

4

Peptides

1

Inhibitory Antibodies

2

Antibodies

4

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114996
    ADAMTS-5 Inhibitor
    4 Publications Verification

    		 ADAMTS Inflammation/Immunology
    ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .
    ADAMTS-5 Inhibitor
  • HY-137430
    Aldumastat
    1 Publications Verification

    GLPG1972; S201086

    		 ADAMTS Metabolic Disease
    Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .
    Aldumastat
  • HY-101448
    TMI-1
    1 Publications Verification

    WAY-171318

    		 MMP Apoptosis Interleukin Related TNF Receptor Caspase Infection Neurological Disease Inflammation/Immunology Cancer
    TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions [4].
    TMI-1
  • HY-145061
    ADAMTS-5-IN-3

    		ADAMTS Metabolic Disease Inflammation/Immunology
    ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .
    ADAMTS-5-IN-3
  • HY-160822
    AGG-523

    PF-5212371

    		 ADAMTS MMP Inflammation/Immunology
    AGG-523 (PF-5212371) is an orally active, reversible, non-hydroxamate, zinc-binding selective inhibitor of ADAMTS4 and ADAMTS5 with IC50 of <0.03 and 0.04 μM. AGG-523 also inhibits MMP-2, -8, 12 activity AGG-523 attenuates release of aggrecanase-generated ARG-aggrecan fragments into synovial fluid, reduces surgery-induced ARG-aggrecan release in rat joint models, and inhibits aggrecanase activity to slow cartilage degradation. AGG-523 can be used for the research of osteoarthritis .
    AGG-523
  • HY-P10398
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA

    		ADAMTS Others
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity .
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA
  • HY-P5419A
    WAAG-3R TFA

    		Biochemical Assay Reagents Others
    WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)
    WAAG-3R TFA
  • HY-RS00304
    ADAMTS4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADAMTS4 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADAMTS4 Human Pre-designed siRNA Set A
    ADAMTS4 Human Pre-designed siRNA Set A
  • HY-RS24577
    Adamts4 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Adamts4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adamts4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Adamts4 Rat Pre-designed siRNA Set A
    Adamts4 Rat Pre-designed siRNA Set A
  • HY-RS18103
    Adamts4 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Adamts4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adamts4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Adamts4 Mouse Pre-designed siRNA Set A
    Adamts4 Mouse Pre-designed siRNA Set A
  • HY-P10468
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2

    		ADAMTS Others
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity .
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2
  • HY-153505
    ADAMTS-4/5-IN-1

    		ADAMTS Inflammation/Immunology
    ADAMTS-4/5-IN-1 is an orally active, and selective dual ADAMTS-4/5 inhibitor with IC50 values of 2 nM for human ADAMTS-4 and human ADAMTS-5, respectively. ADAMTS-4/5-IN-1 exhibits high selectivity against MMP enzymes. ADAMTS-4/5-IN-1 reduces aggrecan degradation products in synovial fluid. ADAMTS-4/5-IN-1 can be used for the research of osteoarthritis .
    ADAMTS-4/5-IN-1
  • HY-RS00303
    ADAMTS3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADAMTS3 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADAMTS3 Human Pre-designed siRNA Set A
    ADAMTS3 Human Pre-designed siRNA Set A
  • HY-P992358
    GSK2394002

    		ADAMTS Cardiovascular Disease
    GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys [4].
    GSK2394002
  • HY-101448R
    TMI-1 (Standard)

    WAY-171318 (Standard)

    		 MMP Reference Standards Apoptosis Interleukin Related TNF Receptor Caspase Infection Neurological Disease Inflammation/Immunology Cancer
    TMI-1 (Standard) is the analytical standard of TMI-1 (HY-101448). This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions [4].
    TMI-1 (Standard)

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