ADAMTS5

By Targets:	ADAMTS (9) AP-1 (3) Bacterial (1) Biochemical Assay Reagents (1) Isotope-Labeled Compounds (1) MMP (4) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: ADAMTS

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12270

T-5224 Maximum Cited Publications 100 Publications Verification	AP-1 MMP	Neurological Disease Inflammation/Immunology Cancer
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-114996

ADAMTS-5 Inhibitor 4 Publications Verification	ADAMTS	Inflammation/Immunology
ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC₅₀ of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .

HY-137430

Aldumastat 1 Publications Verification GLPG1972; S201086	ADAMTS	Metabolic Disease
Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active *ADAMTS-5* (IC₅₀=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC₅₀=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .

HY-135710

ADAMTS-5-IN-2	ADAMTS Bacterial	Infection Inflammation/Immunology
ADAMTS-5-IN-2 is an inhibitor of *ADAMTS-5* (IC₅₀: 9.6 μM) and BoNT/A LC (IC₅₀: 0.71 μM). ADAMTS-5-IN-2 can be used in research related to botulism, osteoarthritis, and other conditions .

HY-145061

ADAMTS-5-IN-3	ADAMTS	Metabolic Disease Inflammation/Immunology
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of *ADAMTS-5* and *ADAMTS-4* with IC₅₀s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .

HY-160822

AGG-523 PF-5212371	ADAMTS MMP	Inflammation/Immunology
AGG-523 (PF-5212371) is an orally active, reversible, non-hydroxamate, zinc-binding selective inhibitor of *ADAMTS4* and *ADAMTS5* with IC₅₀of <0.03 and 0.04 μM. AGG-523 also inhibits MMP-2, -8, 12 activity AGG-523 attenuates release of aggrecanase-generated ARG-aggrecan fragments into synovial fluid, reduces surgery-induced ARG-aggrecan release in rat joint models, and inhibits aggrecanase activity to slow cartilage degradation. AGG-523 can be used for the research of osteoarthritis .

HY-P10398

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-RS00305

ADAMTS5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ADAMTS5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADAMTS5 Human Pre-designed siRNA Set A ADAMTS5 Human Pre-designed siRNA Set A

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-RS18432

Adamts5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adamts5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adamts5 Mouse Pre-designed siRNA Set A Adamts5 Mouse Pre-designed siRNA Set A

HY-RS24913

Adamts5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adamts5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adamts5 Rat Pre-designed siRNA Set A Adamts5 Rat Pre-designed siRNA Set A

HY-12270R

T-5224 (Standard)	AP-1 MMP	Others
T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-P10468

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-180781

ADAMTS-5-IN-4	ADAMTS	Inflammation/Immunology Cancer
ADAMTS-5-IN-4 (Compound 4b) is a selective *ADAMTS5* inhibitor with an IC₅₀ of 9.4 μM. ADAMTS-5-IN-4 significantly inhibits the degradation of Aggrecan in the implants of the osteoarthritis model. ADAMTS-5-IN-4 effectively inhibits the pseudopod elongation and directional migration of ovarian cancer cells. ADAMTS-5-IN-4 shows significant cytotoxicity to HEK293T cells, human chondrocytes, and porcine chondrocyte implants. ADAMTS-5-IN-4 can be used for the study of osteoarthritis and ovarian cancer .

HY-153505

ADAMTS-4/5-IN-1	ADAMTS	Inflammation/Immunology
ADAMTS-4/5-IN-1 is an orally active, and selective dual *ADAMTS-4/5 inhibitor with IC₅₀* values of 2 nM for human *ADAMTS-4* and human *ADAMTS-5, respectively. ADAMTS-4/5-IN-1 exhibits high selectivity against MMP* enzymes. ADAMTS-4/5-IN-1 reduces aggrecan degradation products in synovial fluid. ADAMTS-4/5-IN-1 can be used for the research of osteoarthritis .

HY-12270S

T-5224-d8	Isotope-Labeled Compounds AP-1 MMP	Inflammation/Immunology
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Cat. No.	Product Name	Target	Research Area

HY-P10398

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-P10468

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-P5419

WAAG-3R	Peptides	Others
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

Cat. No.	Product Name	Chemical Structure

HY-12270S

T-5224-d8
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81193

	ADAMTS5 Antibody (YA3480) 1 Publications Verification A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5; A Disintigrin And Metalloproteinase with ThromboSpondin motif-5; ADAM metallopeptidase with thrombospondin type 1 motif 5; ADAM TS 11; ADAM TS 5; ADAM TS5; ADAMTS 11; ADAMTS 5; ADAMTS11; ADMP 2; ADMP2; Aggrecanase 2; aggrecanase-2; FLJ36738; Implantin; ThromboSpondin motif-5.	WB, ICC/IF, FC	Human, Mouse, Rat
	ADAMTS5 Antibody (YA3480) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAMTS5.

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Cat. No.	Product Name		Classification

HY-RS00305

ADAMTS5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ADAMTS5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18432

Adamts5 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Adamts5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24913

Adamts5 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Adamts5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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