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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
ARV771
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "ARV771" in MCE Product Catalog:
30
30 Cited Publications
Research Areas:
ARV-771 is a BET PROTAC degrader, with Kd values of 34, 4.7, 8.3, 7.6, 9.6 and 7.6 nM against BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2) , respectively. ARV-771 inhibits the transcription of AR/AR-v7 and its downstream target genes. By degrading BRD4 protein, ARV-771 enhances the sensitivity of prostate cancer cells to ferroptosis, suppresses cancer cell viability, and induces apoptosis. ARV-771 downregulates the levels of BRD4, c-MYC and AR-V7 in tumor tissues and inhibits tumor tissue growth. ARV-771 can be used in prostate cancer-related research .
Synonyms: VHL ligand 2; E3 ligase Ligand 1A
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Research Areas:
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Cat. No.: HY-42424
CAS No.: 1948273-03-7
Synonyms: VHL ligand 2 hydrochloride; E3 ligase Ligand 1
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(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Cat. No.: HY-42424A
CAS No.: 2504950-56-3
Synonyms: VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride
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(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Cat. No.: HY-158331
CAS No.: 3055593-64-8
Research Areas:
Gal-ARV-771 is a galactose-modified derivative of ARV-771 (HY-100972). Gal-ARV-771 is activated in cells expressing SA-β-Gal, thereby releasing ARV-771. Gal-ARV-771 selectively induces Apoptosis. ARV-771 is a BET PROTAC degrader. Gal-ARV-771 can be used in the research of lung adenocarcinoma (Gal+linker: Gal-PAB (HY-188142); PROTAC: ARV-771 (HY-100972)) .
Cat. No.: HY-42429
CAS No.: 1997304-12-7
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CPI-203-PEG1-C3-O-COOH is a conjugate of the BRD4 ligand (HY-78695) and the linker (HY-42427). CPI-203-PEG1-C3-O-COOH can be used for synthesizing PROTAC BRD4 degrader ARV-771 (HY-100972) .
Cat. No.: HY-100972R
CAS No.: 1949837-12-0
Target:
Reference Standards PROTACs Epigenetic Reader Domain Apoptosis Ferroptosis c-Myc Androgen Receptor
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ARV-771 (Standard) is the analytical standard of ARV-771 (HY-100972). This product is intended for research and analytical applications. ARV-771 is a BET PROTAC degrader, with Kd values of 34, 4.7, 8.3, 7.6, 9.6 and 7.6 nM against BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2) , respectively. ARV-771 inhibits the transcription of AR/AR-v7 and its downstream target genes. By degrading BRD4 protein, ARV-771 enhances the sensitivity of prostate cancer cells to ferroptosis, suppresses cancer cell viability, and induces apoptosis. ARV-771 downregulates the levels of BRD4, c-MYC and AR-V7 in tumor tissues and inhibits tumor tissue growth. ARV-771 can be used in prostate cancer-related research .
Cat. No.: HY-175767
Target:
Research Areas:
PROTAC BRD4 Degrader-39 is a selective targeting Bromodomain protein 4 (BRD4) degrader with an DC50 value of 24.66 nM. PROTAC BRD4 Degrader-39 conjugates BRD PROTAC (ARV-771) (HY-100972) with carbohydrate. PROTAC BRD4 Degrader-39 selectively delivers to tumor cells with high GLUT1 expression, followed by GSH-triggered release of ARV-771 and degrades BRD4. PROTAC BRD4 Degrader-39 can inhibit tumor growth and show no significant toxicity. PROTAC BRD4 Degrader-39 can be used for the research of cancer, such as breast cancer .
Cat. No.: HY-189231
Research Areas:
ARV-771-Azobenzene is an azide-containing PROTAC-Linker conjugate for the construction of PROTAC-antibody conjugates (PACs), consisting of the BRD4 PROTAC ARV-771 (HY-100972) and an azobenzene linker cleavable by azoreductase. ARV-771-Azobenzene acts as a payload for conjugation with DBCO-modified antibodies. Conjugation of ARV-771-Azobenzene with DBCO-modified Sacituzumab generates the azoreductase-cleavable SAC-ARV-771 conjugate (ASA). Conjugation of ARV-771-Azobenzene with DBCO-modified IgG generates IgG-ARV-771. ARV-771-Azobenzene is applicable to studies on hypoxia-responsive antibody-PROTAC conjugates and triple-negative breast cancer .
Cat. No.: HY-W946627
CAS No.: 2683008-64-0
Research Areas:
(S,R,S)-AHPC-Me-amide-C-O-C3-PEG1-NH2 is a conjugate of an E3 ligand and linker, which can be used for the synthesis of PROTACs, such as ARV-771 (HY-100972) .
Cat. No.: HY-188142
CAS No.: 259684-23-6
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Gal-PAB is a galactose-linker conjugate that can be used for the synthesis of the galactose-modified PROTAC prodrug Gal-ARV-771 (HY-158331). Gal-PAB is applicable to lung cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
