2. PROTAC Epigenetics Apoptosis
  3. PROTACs Epigenetic Reader Domain Apoptosis
  4. Gal-ARV-771

Gal-ARV-771, PROTAC prodrug, is a gal modified ARV-771 (HY-100972). Gal-ARV-771 can be activated in SA-β-Gal-expressed cancer senescent cells to release ARV-771. Gal-ARV-771 induces selective degradation of BRD4 protein by the ubiquitin-proteasome pathway in senescent cells. Gal-ARV-771 promotes apoptosis of senescent cancer cells.

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Gal-ARV-771 Chemical Structure

Gal-ARV-771 Chemical Structure

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Gal-ARV-771 Related Antibodies

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Description

Gal-ARV-771, PROTAC prodrug, is a gal modified ARV-771 (HY-100972). Gal-ARV-771 can be activated in SA-β-Gal-expressed cancer senescent cells to release ARV-771. Gal-ARV-771 induces selective degradation of BRD4 protein by the ubiquitin-proteasome pathway in senescent cells. Gal-ARV-771 promotes apoptosis of senescent cancer cells[1].

IC50 & Target[1]

BRD4

 

Molecular Weight

1467.06

Formula

C71H84ClN9O19S2
Unlabeled CAS

SMILES

O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)OC(OCC4=CC=C(O[C@@H]([C@@H]5OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]5OC(C)=O)C=C4)=O)C([C@H](C(C)(C)C)NC(COCCCOCCNC(C[C@@H]6N=C(C7=C(N8C(C)=NN=C68)SC(C)=C7C)C9=CC=C(C=C9)Cl)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gal-ARV-771 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gal-ARV-771PROTACsEpigenetic Reader DomainApoptosisA549 xenograftSA-β-Gal senescentInhibitorinhibitorinhibit

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HY-158331
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