Gal-ARV-771
Gal-ARV-771, PROTAC prodrug, is a gal modified ARV-771 (HY-100972). Gal-ARV-771 can be activated in SA-β-Gal-expressed cancer senescent cells to release ARV-771. Gal-ARV-771 induces selective degradation of BRD4 protein by the ubiquitin-proteasome pathway in senescent cells. Gal-ARV-771 promotes apoptosis of senescent cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 3055593-64-8
- Formula: C71H84ClN9O19S2
- Molecular Weight:1467.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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BRD4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.29 μM
Compound: Gal-ARV-771
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Antiproliferative activity against human normal (non-senescent) A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human normal (non-senescent) A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 38635879] |
| A549 | IC50 |
354 nM
Compound: Gal-ARV-771
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Antiproliferative activity against human senescent A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human senescent A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 38635879] |
Chemical Information
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CAS No. 3055593-64-8
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Molecular Weight 1467.06
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Formula C71H84ClN9O19S2
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SMILES
O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)OC(OCC4=CC=C(O[C@@H]([C@@H]5OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]5OC(C)=O)C=C4)=O)C([C@H](C(C)(C)C)NC(COCCCOCCNC(C[C@@H]6N=C(C7=C(N8C(C)=NN=C68)SC(C)=C7C)C9=CC=C(C=C9)Cl)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gal-ARV-771 Related Classifications
HY-158331 Related Classifications
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