5 Results for "

ASIC2a

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "ASIC2a" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P1441A
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
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Cat. No.: HY-101005
CAS No.: 16503-22-3
Synonyms: Nα-Methylhistamine dihydrochloride
Research Areas:  

Infection

N-Methylhistamine dihydrochloride (Nα-Methylhistamine dihydrochloride) is a non-selective Histamine receptor agonist. N-Methylhistamine dihydrochloride activates histamine H1, H2 and H3 receptors; it stimulates central H1 receptors by activating sympathetic α and β adrenergic receptors to inhibit intestinal transit, exerts dose-dependent inhibition on intestinal transit, reduces histamine turnover in mouse brains, and increases gastric acid secretion without altering plasma gastrin concentrations. N-Methylhistamine dihydrochloride produces a pH-dependent, voltage-independent potentiating effect on acid-sensing ion channel 1a, and shows no significant activity toward homologous ASIC2a channels. N-Methylhistamine dihydrochloride can be used in studies related to Helicobacter pylori infection [2] .
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Cat. No.: HY-P5174
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC50 values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation .
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Cat. No.: HY-P5172
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .
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Cat. No.: HY-RS01090
Research Areas:  

Others

ASIC2 Human Pre-designed siRNA Set A contains three designed siRNAs for ASIC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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