Activator protein-1 (AP-1)

By Targets:	AP-1 (3) Apoptosis (3) CDK (1) COX (3) Interleukin Related (1) JNK (3) NF-κB (5) NO Synthase (1) PPAR (2) Prostaglandin Receptor (1) Reference Standards (3) TNF Receptor (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (2)

Targets Recommended: AP-1 AAK1 MetAP VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15870

SR 11302 Maximum Cited Publications 24 Publications Verification	AP-1	Inflammation/Immunology Cancer
SR 11302 is an **activator protein-1** (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-N0510

Aristolochic acid A 5+ Cited Publications Aristolochic acid I; TR 1736	NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

HY-110177

SP-100030 1 Publications Verification	NF-κB	Inflammation/Immunology
SP-100030 is a potent NF-κB and **activator protein-1 (AP-1) double inhibitor (IC₅₀**s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA) .

HY-W010983

SC-236 2 Publications Verification	COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC₅₀ = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .

HY-N0510A

Aristolochic acid A sodium 5+ Cited Publications Aristolochic acid I sodium; TR 1736 sodium	NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aristolochic acid A (Aristolochic acid I) sodium is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A sodium significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A sodium reduces BLCAP gene expression in human cell lines .

HY-100233

IQ-1S free acid 1 Publications Verification	JNK	Inflammation/Immunology Cancer
IQ-1S free acid is a prospective inhibitor of *NF-κB*/activating protein 1 (AP-1) activity with an IC₅₀ of 2.3±0.41 μM. IQ-1S free acid has binding affinity (K_d values) in the nanomolar range for all three JNKs with K_ds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.

HY-15870A

(6E)-SR 11302	AP-1	Inflammation/Immunology Cancer
(6E)-SR 11302 is a E-isomer of SR 11302. SR 11302 is an **activator protein-1** (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-113443

12(S)-HPETE	AP-1	Metabolic Disease
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases **activating protein 1 (AP-1)** activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

HY-W010983R

SC-236 (Standard)	Reference Standards COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .

HY-100233A

IQ-1S	JNK	Inflammation/Immunology Cancer
IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC₅₀ of 1.8 μM. IQ-1 has binding affinity (K_d values) in the nanomolar range for all three JNKs with K_ds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and JNK1, respectively.

HY-N0510R

Aristolochic acid A (Standard) Aristolochic acid I (Standard); TR 1736 (Standard)	Reference Standards NF-κB	Cancer
Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

HY-100233R

IQ-1S free acid (Standard)	JNK Reference Standards	Inflammation/Immunology Cancer
IQ-1S (free acid) (Standard) is the analytical standard of IQ-1S (free acid) (HY-100233). This product is intended for research and analytical applications. IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 2.3±0.41 μM. IQ-1S free acid has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.

HY-N17736

Chikusetsusaponin IVa methyl ester CME	NF-κB COX Interleukin Related TNF Receptor NO Synthase Prostaglandin Receptor CDK β-catenin Wnt Apoptosis	Inflammation/Immunology Cancer
Chikusetsusaponin IVa methyl ester (CME) is a natural triterpenoid saponin compound. Chikusetsusaponin IVa methyl ester induces G0/G1 cell cycle arrest and apoptosis in colon cancer cells by inhibiting the Wnt/β-catenin signaling pathway. By inhibiting the NF-κB and AP-1 signaling pathways, Chikusetsusaponin IVa methyl ester significantly reduces the production of NO, PGE₂ and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and downregulates the levels of iNOS and COX-2. Chikusetsusaponin IVa methyl ester can be used in researches on colorectal cancer and inflammation .

Cat. No.	Product Name	Type

HY-N0510A

Aristolochic acid A sodium 5+ Cited Publications Aristolochic acid I sodium; TR 1736 sodium	Biochemical Assay Reagents
Aristolochic acid A (Aristolochic acid I) sodium is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A sodium significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A sodium reduces BLCAP gene expression in human cell lines .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0510

Aristolochic acid A 5+ Cited Publications Aristolochic acid I; TR 1736	Alkaloids Structural Classification other families Aristolochia debilis Sieb. et Zucc. Classification of Application Fields Other Alkaloids Plants Aristolochiaceae Disease Research Fields Source Classification Cancer	NF-κB
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

HY-113443

12(S)-HPETE	Microorganisms Source Classification	AP-1
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases **activating protein 1 (AP-1)** activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

HY-N0510R

Aristolochic acid A (Standard) Aristolochic acid I (Standard); TR 1736 (Standard)	Alkaloids Structural Classification other families Aristolochia debilis Sieb. et Zucc. Other Alkaloids Plants Aristolochiaceae Source Classification	Reference Standards NF-κB
Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

HY-N17736

Chikusetsusaponin IVa methyl ester CME	Structural Classification Terpenoids Achyranthes bidentata var. japonica Miq. Amaranthaceae Plants Pentacyclic Triterpenoids Source Classification	NF-κB COX Interleukin Related TNF Receptor NO Synthase Prostaglandin Receptor CDK β-catenin Wnt Apoptosis
Chikusetsusaponin IVa methyl ester (CME) is a natural triterpenoid saponin compound. Chikusetsusaponin IVa methyl ester induces G0/G1 cell cycle arrest and apoptosis in colon cancer cells by inhibiting the Wnt/β-catenin signaling pathway. By inhibiting the NF-κB and AP-1 signaling pathways, Chikusetsusaponin IVa methyl ester significantly reduces the production of NO, PGE₂ and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and downregulates the levels of iNOS and COX-2. Chikusetsusaponin IVa methyl ester can be used in researches on colorectal cancer and inflammation .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702589

	JUN Protein, Human (His, Myc) Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	Human	E. coli
	JUN Protein, Human (His, Myc) is the recombinant human-derived JUN, expressed by E. coli , with N-10*His, C-Myc labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Rabbit (12)
Reactivity:	Human (12) Rat (11) Mouse (11)
Application:	IHC-P (8) ICC/IF (5) IF-Tissue (3) IP (6) WB (12) ChIP (2) FC (2)
Isotype:	IgG (12)
Conjugation:	Non-conjugated (12)
Clonality:	Polyclonal (2) Monoclonal (8) Recombinant (8)
Modification:	Phosphorylated (5) Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80800

	Phospho-c-Jun (Ser243) Antibody Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser243) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-c-Jun (Ser243).

HY-P80802

	Phospho-c-Jun (Ser73) Antibody Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser73) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-c-Jun (Ser73).

HY-P80801

	Phospho-c-Jun (Ser63) Antibody (YA215) Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody (YA215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Jun (Ser63).

HY-P80801A

	Phospho-c-Jun (Ser63) Antibody (YA215)(PBS only) Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody (YA215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Jun (Ser63).

HY-P83342

	Phospho-JunD (Ser255) Antibody (YA3087) Activator protein 1; AP 1; Jun D; jun D proto oncogene; Jund; JunD FL isoform; Transcription factor jun D	WB, IP	Human, Mouse, Rat
	Phospho-JunD (Ser255) Antibody (YA3087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-JunD (Ser255).

HY-P82861

	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUND; Transcription factor jun-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Jun/JunD (Ser73/Ser100).

HY-P82861A

	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606)(PBS only) JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUND; Transcription factor jun-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Jun/JunD (Ser73/Ser100).

HY-P810405

	Phospho-c-Jun (S73)+JunD (S100) Antibody (YA9720) Activator protein 1, AP 1, AP-1, AP1, cJun, Enhancer Binding protein AP1, Jun Activation Domain Binding protein, JUN, Jun oncogene, JUN protein	WB, ICC/IF, FC	Human, Mouse, Rat
	Phospho-c-Jun (S73)+JunD (S100) Antibody (YA9720) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Phospho-c-Jun(S73)+JunD(S100) .

HY-P810403

	JunD Antibody (YA9718) Activator protein 1, AP 1, AP1, Jun D, jun D proto oncogene, Jund, JunD FL isoform, JUND_HUMAN, Transcription factor jun D, Transcription factor jun-D	WB, ICC/IF, IHC-P, ChIP, IP	Human, Mouse, Rat
	JunD Antibody (YA9718) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to JunD.

HY-P810404

	JunD Antibody (YA9719) Activator protein 1, AP 1, AP1, Jun D, jun D proto oncogene, Jund, JunD FL isoform, JUND_HUMAN, Transcription factor jun D, Transcription factor jun-D	WB, ICC/IF, IF-Tissue, IP, IHC-P, FC	Human
	JunD Antibody (YA9719) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to JunD.

HY-P810402

	Phospho-JunD (Ser255) Antibody (YA9717) Activator protein 1, AP 1, AP1, Jun D, jun D proto oncogene, Jund, JunD FL isoform, JUND_HUMAN, Transcription factor jun D, Transcription factor jun-D	WB, ICC/IF, IF-Tissue, IHC-P	Human, Mouse, Rat
	Phospho-JunD (Ser255) Antibody (YA9717) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Phospho-JunD(Ser255).

HY-P810442

	c-fos Antibody (YA9752) Activator protein 1, AP 1, C FOS, Cellular oncogene c fos, Cellular oncogene fos, FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, FBJ murine osteosarcoma viral v fos oncogene homolog, FBJ Osteosarcoma Virus, FOS	WB, IHC-P, ICC/IF, IP, ChIP, IF-Tissue	Human, Mouse, Rat
	c-fos Antibody (YA9752) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to c-fos.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Activator protein-1 (AP-1)

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Antibodies

Natural
Products