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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Apoptosis signal-regulating kinase 1
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Apoptosis signal-regulating kinase 1" in MCE Product Catalog:
25
Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.
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TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM) .
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ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM) .
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ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis .
Cat. No.: HY-18297
CAS No.: 1124381-69-6
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ASK1-IN-5 (S-99) is an inhibitor of apoptosis signal-regulated kinase 1 (ASK1) and is useful in the study of autoimmune and neurodegenerative diseases .
Cat. No.: HY-152247
CAS No.: 2673364-10-6
DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC50 =164.1 nM) not ASK2 (IC50>20 μM). DDO3711 significantly dephosphorylates p-ASK1 T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research .
Cat. No.: HY-176880
CAS No.: 2247064-34-0
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ASK1-IN-9 (Compound 3) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 <200 nM. ASK1-IN-9 can be used for the research of inflammation .
Cat. No.: HY-110262
CAS No.: 1124381-43-6
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MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC50 of 96 nM. MSC 2032964A preserves the visual responses in EAE mice model and exhibits potency in ameliorating the neuroinflammation .
Cat. No.: HY-176882
CAS No.: 2247064-44-2
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ASK1-IN-11 (Compound 7) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 <200 nM. ASK1-IN-11 also shows inhibitory activities to TNF-α, MYLK/MLCK Kinase and hERG potassium channels . ASK1-IN-11 can be used for the research of inflammation .
Cat. No.: HY-176881
CAS No.: 2247064-84-0
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ASK1-IN-10 (Compound 27) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 <200 nM. ASK1-IN-10 also shows inhibitory activity to hERG potassium channels. ASK1-IN-10 can be used for the research of inflammation .
Cat. No.: HY-111125
CAS No.: 923515-92-8
AMRI-59 is a potent inhibitor of PrxI used for parasitic infections. AMRI-59 can increase cellular ROS, leading to activation of signaling pathways mediated by mitochondria and apoptosis signal-regulated kinase 1, thereby leading to apoptosis in A549 human lung adenocarcinoma. AMRI-59 exhibits significant antitumor activity without apparent acute toxicity .
Cat. No.: HY-P701705
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K5; MEK kinase 5; Prev. MEKK5; ASK-1; MAPKKK5; Mitogen-Activated Protein kinase kinase kinase; ASK1; Apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5; Mitogen-Activated Protein kinase kinase kinase 5; MEKK 5
Species:
Human
Source:
E. coli
Cat. No.: HY-173293
CAS No.: 2570985-89-4
Target:
Research Areas:
ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM . In an experimental mouse model of liver injury induced by Acetaminophen (HY-66005), ASK1-IN-8 can significantly reduce the plasma alanine transaminase (ALT) level, protecting the liver . ASK1-IN-8 can be used in research related to liver diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
