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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
C5AR1
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "C5AR1" in MCE Product Catalog:
14
14 Publications Verification
Cat. No.: HY-110136A
Purity: 99.50%
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PMX 205 Trifluoroacetate is a specific complement C5aR1 isoform antagonist .
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5
5 Cited Publications
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JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 μM) and reduces TNF levels (EC50=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases .
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3 Cited Publications
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Cat. No.: HY-P99450
CAS No.: 2226393-85-5
Synonyms: IPH 5401; Anti-C5AR1 mAb
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Cat. No.: HY-163378
CAS No.: 2365325-67-1
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C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases .
Cat. No.: HY-P10639
CAS No.: 2097449-46-0
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Cat. No.: HY-163379
CAS No.: 2365161-92-6
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C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC50 values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases .
Cat. No.: HY-P990745
CAS No.: 2769937-42-8
Synonyms: HIB210; MOR044254; MOR210; TJ-210; TJ-210001; WBP2191
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Cat. No.: HY-RS01750
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C5AR1 Human Pre-designed siRNA Set A contains three designed siRNAs for C5AR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P5509
CAS No.: 230968-98-6
Cat. No.: HY-177094
CAS No.: 2489430-53-5
Synonyms: INF056
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Izicopan (INF056) is a complement factor C5a receptor (C5aR1) antagonist. Izicopan inhibits C5a-induced calcium mobilization with an IC50 of 10-100 nM. Izicopan is applicable for the research of complement-mediated inflammatory responses .
Cat. No.: HY-P990376
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Cat. No.: HY-RS18377
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C5ar1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for C5ar1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24857
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C5ar1 Rat Pre-designed siRNA Set A contains three designed siRNAs for C5ar1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W130878
CAS No.: 1806-26-4
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4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway .
Cat. No.: HY-157472
CAS No.: 2363082-87-3
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ACT-1014-6470 is an orally active, potent, reversible, and selective C5aR1 antagonist. ACT-1014-6470 demonstrates potent inhibition of C5aR1 activation. ACT-1014-6470 can be used in the research of inflammatory diseases .
Cat. No.: HY-P991485
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Cat. No.: HY-P10639A
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Cat. No.: HY-W157299
CAS No.: 500912-17-4
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2-(Bromomethyl)-1-fluoro-3-methoxybenzene (compound 62) is a synthetic intermediate used in the preparation of dihydroquinazolinone-based C5aR1 antagonists .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
