57 Results for "

CD27

" in MedChemExpress (MCE) Product Catalog:
Products (57)

57 Results for "CD27" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99014
CAS No.: 1864871-20-4
Synonyms: ARGX-110

Research Areas:  

Inflammation/Immunology Cancer

Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .
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Cat. No.: HY-P99057
CAS No.: 1393344-72-3
Synonyms: CDX-1127
Varlilumab (CDX-1127) is an agonist anti-CD27 monoclonal antibody. Varlilumab can promote T cell expansion and activate the immune response. Varlilumab has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors .
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Cat. No.: HY-P990018
CAS No.: 2444297-08-7
Synonyms: MK-5890

Target:  

TNF Receptor NF-κB

Research Areas:  

Inflammation/Immunology Cancer

Boserolimab (MK-5890) is a humanized agonist monoclonal antibody that binds to CD27 to provide a costimulatory signal that enhances T-cell–mediated responses .
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Cat. No.: HY-159886
CAS No.: 877164-43-7
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

MG-C-30 is an orally active agonist for CD27 with an EC50 of 0.84 μM. MG-C-30 activates NK cells and T cell co-stimulatory signals, and enhances immune response. MG-C-30 exhibits antitumor efficacy in mouse EG7-OVA model .
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Cat. No.: HY-P991661
CAS No.: 1607838-85-6
AMG-172 Antibody is an anti-CD27L antibody. AMG-172 Antibody can be used for synthesis of ADC AMG-172 (HY-185483) .
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Cat. No.: HY-P990280
Anti-Mouse CD27 Antibody (RM27-3E5) is an agonistic rat-derived IgG2a κ type antibody, targeting to mouse CD27. Anti-Mouse CD27 Antibody (RM27-3E5) stimulates CD 27. Anti-Mouse CD27 Antibody (RM27-3E5) can be used for the researches of cancer and immunology, such as B16cOVA tumor .
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Cat. No.: HY-P991063
CAS No.: 2733575-82-9
Synonyms: BNT-313; Tixestobart

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

GEN-1053 (BNT-313) is a fully human IgG1 antibody that targets CD27. GEN-1053 binds to CD27 and forms a hexamer upon binding. The isotype control for GEN-1053 can refer to Human IgG1 lambda1, Isotype Control (HY-P99992) .
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Cat. No.: HY-RS02216
Research Areas:  

Others

CD27 Human Pre-designed siRNA Set A contains three designed siRNAs for CD27 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS16844
Research Areas:  

Others

Cd27 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd27 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23285
Research Areas:  

Others

Cd27 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd27 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-120255
CAS No.: 155976-53-7
Synonyms: 17(R)-HDoHE
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology

17(R)-HDHA (17(R)-HDoHE) is a pro-resolving mediator (SPM). 17(R)-HDHA enhances the differentiation of B cells toward the CD27(+)CD38(+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17(R)-HDHA does not affect cell proliferation and is non-toxic to cells .
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Cat. No.: HY-P99057A
CAS No.: 1393344-72-3
Synonyms: CDX-1127 (anti-CD27)
Varlilumab (CDX-1127) (anti-CD27) is an agonist anti-CD27 monoclonal antibody. Varlilumab (anti-CD27) can promote T cell expansion and activate the immune response. Varlilumab (anti-CD27) has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors .
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Cat. No.: HY-P991465

Target:  

TNF Receptor

Research Areas:  

Cancer

Anti-CD27 Antibody (M2177) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2177) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2177) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P991466

Target:  

TNF Receptor

Research Areas:  

Cancer

Anti-CD27 Antibody (M2191) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2191) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2191) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P990528

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Anti-TNFRSF7/CD27 Antibody is a CHO-expressed human antibody targeting TNFRSF7/CD27. The Anti-TNFRSF7/CD27 Antibody contains huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-TNFRSF7/CD27 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).
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Cat. No.: HY-P7832
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rRhTAPBPL/CD27, His; CD27 Antigen; CD27L Receptor; T-Cell Activation Antigen CD27; T14; Tumor Necrosis Factor Receptor Superfamily Member 7; CD27; CD27; TNFRSF7
Species:  
Source:  
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Cat. No.: HY-P704269
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD27 antigen; CD27; T-cell activation antigen CD27; T14; TNFRSF7
Species:  
Source:  
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Cat. No.: HY-P704274
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD27 antigen; CD27; T-cell activation antigen CD27; T14; TNFRSF7
Species:  
Source:  
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Cat. No.: HY-P72743
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD27 antigen; CD27; T-cell activation antigen CD27; T14; TNFRSF7
Species:  
Source:  
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Cat. No.: HY-P72744
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD27 antigen; CD27; T-cell activation antigen CD27; T14; TNFRSF7
Species:  
Source:  
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