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Results for "

CSN5

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112134
    CSN5i-3
    20+ Cited Publications

    		 Deubiquitinase Cancer
    CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM .
    CSN5i-3
  • HY-159601
    CSN5-IN-1

    		PD-1/PD-L1 E1/E2/E3 Enzyme Cancer
    CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC50 values of 12.56 μM and 19 μM as measured by FP assay and fluorescence assay, respectively. CSN5-IN-1 can also downregulate the expression of PD-L1 and upregulate the expression of NEDD8-Cul1 in cells .
    CSN5-IN-1
  • HY-112134A
    (R)-CSN5i-3

    		AP-1 Cancer
    (R)-CSN5i-3 is the (R)-enantiomer of CSN5i-3. CSN5i-3 is a potent, selective and orally available inhibitor of CSN5 .
    (R)-CSN5i-3
  • HY-172252
    CSN5-IN-2

    		PD-1/PD-L1 RAD51 Cancer
    CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. CSN5-IN-2 can increase the level of Cullin 1 neddylation, and downregulate the expression of RAD51 and PD-L1 in cancer cells. CSN5-IN-2 has anti-tumor activity, and its effect is better when combined with Talazoparib (HY-16106) .
    CSN5-IN-2
  • HY-181795
    CSN5-IN-3

    		PD-1/PD-L1 Bcl-2 Family MDM-2/p53 Caspase Cancer
    CSN5-IN-3 (Compound 30) is a CSN5 inhibitor with an IC50 of 0.58 μM. CSN5-IN-3 inhibits the enzymatic activity of CSN5, leading to increased accumulation of NEDD8-Cul1 and promoting the degradation of PD-L1. CSN5-IN-3 downregulates Bcl-2, and upregulates P53 and Cleaved caspase-3. CSN5-IN-3 exhibits anticancer activity against triple-negative breast cancer .
    CSN5-IN-3
  • HY-182239
    PDL1 degrader-3

    		PD-1/PD-L1 Cancer
    PDL1 degrader-3 (comppund e24) is a CSN5-binding antitumor immunomodulator with a human CSN5 Kd of 4.53 μM. PDL1 degrader-3 inhibits CSN5 enzymatic activity, increases PD-L1 ubiquitination, and induces PD-L1 degradation via the ubiquitin-proteasome pathway, reducing PD-L1 expression on tumor cell membranes. PDL1 degrader-3 blocks PD-1/PD-L1 interaction, activates the tumor immune microenvironment, enhances tumor-infiltrating T-cell immunity, and inhibits activation of immunosuppressive MDSCs and Tregs. PDL1 degrader-3 exerts antitumor effects in mouse tumor models. PDL1 degrader-3 can be used for the research of colorectal cancer, lung cancer .
    PDL1 degrader-3
  • HY-RS03030
    COPS5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    COPS5 Human Pre-designed siRNA Set A contains three designed siRNAs for COPS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    COPS5 Human Pre-designed siRNA Set A
    COPS5 Human Pre-designed siRNA Set A
  • HY-RS19669
    Cops5 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cops5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cops5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cops5 Mouse Pre-designed siRNA Set A
    Cops5 Mouse Pre-designed siRNA Set A

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