Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
Cap1
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "Cap1" in MCE Product Catalog:
2
研究分野:
Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria [1] .
1
1 Cited Publications
製品番号: HY-P71625
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: PARK7; Parkinsonism-Associated Deglycase; Parkinsonism Associated Deglycase; Parkinson Disease Protein 7; DJ-1; Parkinson Protein 7; Protein/Nucleic Acid Deglycase DJ-1; Oncogene DJ1; Maillard Deglycase; Epididymis Secretory Sperm Binding Protein Li 67p;
製品番号: HY-174497
eGFP mRNA expresses green fluorescent protein derived from the jellyfish Aequorea victoria. eGFP is a commonly used direct-detection reporter gene in mammalian cell culture, which produces bright green fluorescence. This product is synthesized without modified nucleosides, with a Cap1 version cap analog at the 5' end and a 100nt PolyA tail at the 3' end. It can be used as a positive reference for IVT (in vitro transcription) or LNP delivery systems.
製品番号: HY-145973A
純度: ≥99.0%
別名: m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM)
製品番号: HY-158772
純度: 99.6%
Target:
研究分野:
m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) is a trinucleotide cap analog with a Cap1 structure. m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) can be co-transcriptionally incorporated into the 5' end of mRNA during T7 RNA polymerase-mediated in vitro transcription to form a natural Cap1 cap structure. m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) enhances mRNA translation efficiency and reduces innate immune recognition, and it has been used in the preparation of self-amplifying mRNA rabies vaccines. m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) can be applied to research related to in vitro mRNA transcription and mRNA vaccines [1].
製品番号: HY-E70081
Target:
研究分野:
mRNA Cap 2'-O-methyltransferase uses S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2'-O position of the first nucleotide at the 5’ end of Cap-0 mRNA, resulting in Cap-1 structure. Cap-1 structure promotes translation efficiency, increasing subsequent protein expression [1].
製品番号: HY-P6355
CAS 番号: 198274-43-0
Target:
研究分野:
製品番号: HY-A0148
CAS 番号: 69756-53-2
別名: SKF-102886 free base; WR-171669
Halofantrine (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria [1] .
製品番号: HY-RS01880
Target:
研究分野:
CAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-145973
CAS 番号: 2089461-55-0
別名: m7(3'OMeG)(5')ppp(5')(2'OMeA)pG
研究分野:
3’OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3’OMe-m7GpppAmpG effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3’OMe-m7GpppAmpG is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research [1] .
製品番号: HY-RS17877
Target:
研究分野:
Cap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS24346
Target:
研究分野:
Cap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-145979
CAS 番号: 2638447-87-5
Target:
研究分野:
m7GpppUmpG, an oligonucleotide, is an M 7GpppNpG trinucleotide cap analogue. m7GpppUmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures [1].
製品番号: HY-145980
CAS 番号: 2638447-85-3
Target:
研究分野:
m7GpppUpG, an oligonucleotide, is an M 7GpppNpG trinucleotide cap analogue. m7GpppUpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures [1].
製品番号: HY-145981
CAS 番号: 2638447-78-4
Target:
研究分野:
m7GpppCpG, an oligonucleotide, is an M 7GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures [1].
製品番号: HY-145982
CAS 番号: 2089461-56-1
Target:
研究分野:
m7GpppCmpG, an oligonucleotide, is an M 7GpppNpG trinucleotide cap analogue. m7GpppCmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures [1].
製品番号: HY-145976
CAS 番号: 133608-76-1
研究分野:
m7GpppGpG is an unmodified trinucleotide cap analog with enhancer activity. When incorporated into mRNA, it effectively enhances translational efficiency, stability, and protein expression levels of the mRNA. m7GpppGpG can serve as a standard cap analog for in vitro mRNA synthesis to support antigen generation and presentation by dendritic cells, although its expression efficiency in dendritic cells is 20-fold lower than that of the m7GpppApG cap .
製品番号: HY-A0148AR
CAS 番号: 36167-63-2
別名: SKF-102886 (Standard); WR-171669 hydrochloride (Standard)
研究分野:
Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
