49 Results for "

Cys474

" in MedChemExpress (MCE) Product Catalog:
Products (49)

49 Results for "Cys474" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-P0171
CAS No.: 664334-36-5
Synonyms: BKT140 (4-fluorobenzoyl); BL-8040; TF14016
Target:  

CXCR

Research Areas:  

Endocrinology Cancer

Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ~1 nM.
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3
3 Cited Publications
Cat. No.: HY-47573
CAS No.: 2750414-35-6
CCG273441 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle .
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2
2 Cited Publications
Cat. No.: HY-12554A
CAS No.: 1884420-36-3
Purity:  99.76%
Terlipressin diacetate is a vasopressin analogue with potent vasoactive properties. Terlipressin diacetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin diacetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin diacetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .
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1
1 Cited Publications
Cat. No.: HY-P1304
CAS No.: 214050-22-3
Research Areas:  

Neurological Disease

CART(55-102)(human) is an endogenous satiety factor with potent appetite-suppressing activity. CART(55-102)(human) is closely associated with leptin and neuropeptide Y .
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1
1 Cited Publications
Cat. No.: HY-P1604
CAS No.: 60748-45-0
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
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1
1 Cited Publications
Cat. No.: HY-P1604A
ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
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Cat. No.: HY-108741
CAS No.: 467426-54-6
Purity:  99.93%
Target:  

Guanylate Cyclase

Research Areas:  

Inflammation/Immunology Cancer

Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis .
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Cat. No.: HY-12554
CAS No.: 14636-12-5
Terlipressin is a vasopressin analogue with potent vasoactive properties. Terlipressin is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin exerts anti-inflammatory and anti-oxidative effects. Terlipressin has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .
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Cat. No.: HY-P3732
CAS No.: 332179-76-7
Target:  

Integrin

Research Areas:  

Cancer

RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models .
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Cat. No.: HY-P3499
CAS No.: 1092457-65-2
Target:  

Guanylate Cyclase

Research Areas:  

Inflammation/Immunology

Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research .
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Cat. No.: HY-106302
CAS No.: 1391-36-2
Purity:  99.46%
Synonyms: Moli1901; Lancovutide
Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) .
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Cat. No.: HY-108741A
CAS No.: 1075732-84-1
Purity:  99.51%
Target:  

Guanylate Cyclase

Research Areas:  

Inflammation/Immunology Cancer

Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis .
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Cat. No.: HY-P1305
CAS No.: 209615-79-2
Research Areas:  

Neurological Disease

CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior .
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Cat. No.: HY-P3099
CAS No.: 154525-25-4
Target:  

Guanylate Cyclase

Research Areas:  

Cancer

Uroguanylin (human) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer .
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Cat. No.: HY-P5681
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .
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Cat. No.: HY-P3912A
Target:  

Interleukin Related

Research Areas:  

Infection

Endotoxin inhibitor TFA is a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor TFA inhibits the febrile response to LPS with very low toxicity and lethality .
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Cat. No.: HY-P1457
CAS No.: 154765-05-6
Target:  

Peptides

Research Areas:  

Cardiovascular Disease

Adrenomedullin (AM) (13-52), human is a 40 amino acid peptide, which acts as an endothelium-dependent vasodilator agent.
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Cat. No.: HY-P3099A
Target:  

Guanylate Cyclase

Research Areas:  

Cancer

Uroguanylin (human) (TFA) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) (TFA) has anti-tumor actions in an animal model for human colon cancer .
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Cat. No.: HY-P5077A
Target:  

Guanylate Cyclase

Research Areas:  

Metabolic Disease

Guanylin (mouse, rat) TFA, a petide, is composed of 15 amino acids. Guanylin (mouse, rat) TFA is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) TFA can be used for the research of diarrhea .
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Cat. No.: HY-P5300A
Target:  

Peptides

Research Areas:  

Others

YNPCVMYL (Thioester: Cys4-Leu8) TFA is a polypeptide chain of the YNPCVMYL sequence. The link between the fourth and eighth amino acids in the sequence has the properties of a thioester, which is formed between cysteine (Cys4) and leucine (Leu8).
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