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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
DAC
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "DAC" in MCE Product Catalog:
36
36 Cited Publications
Synonyms: TTI-101
Target:
Áreas de investigación:
C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .
Referencia número: HY-174979
No. CAS: 3084407-00-8
Áreas de investigación:
Dac590 is an orally active and selective obesity-associated protein (FTO) inhibitor with an IC50 of 6.06 nM. Dac590 shows highly selective over ALKBH5 and ALKBH3. Dac590 suppresses oncogenic FTO signaling, induces myeloid differentiation, G1-phase cell cycle arrest, and apoptosis in acute myeloid leukemia (AML) cells. Dac590 inhibits xenograft tumor growth and prolongs survival in acute myeloid leukemia mouse models with no observed toxicity. Dac590 can be used for the research of AML .
Referencia número: HY-129709
No. CAS: 124065-13-0
Target:
Áreas de investigación:
DAC 5945 is a potent muscarinic antagonist in the airways than in the heart, with pKi values of 8.3 and 7.52 for M1 and M2, respectively .
Referencia número: HY-RS00017
Target:
Áreas de investigación:
AADAC Human Pre-designed siRNA Set A contains three designed siRNAs for AADAC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
0 Images
DNA, d(A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T)
Referencia número: HY-150214
No. CAS: 1817821-77-4
Referencia número: HY-186226
No. CAS: 3113309-33-1
Target:
Áreas de investigación:
KVL‑9 is an intermediate for constructing KRAS-degrading antibody-drug conjugates (DAC), consisting of a KRAS small-molecule binder, a spacer, a VHL-recruiting ligand, and a cleavable antibody linker. By conjugating with tumor antigen-targeting antibodies, KVL‑9 enables antigen-dependent intracellular delivery and induces VHL‑mediated ubiquitin‑proteasome degradation of KRAS protein. KVL‑9 can be used for the synthesis of DACs. KVL‑9 is applicable to cancer research .
Referencia número: HY-P704100
Pureza: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: AAAD_HUMAN; Aada; AaDAC; Arylacetamide deacetylase (esterase); Arylacetamide deacetylase; CES5A1; DAC
Referencia número: HY-183939
No. CAS: 2760138-46-1
Target:
Áreas de investigación:
L1-CIDE-BRM1-13 (Compound 15) is a linker-drug precursor moiety formed by the covalent conjugation of a PROTAC degrader with a linker for degrader-antibody conjugates (DACs). L1-CIDE-BRM1-13 can be used for the synthesis of DACs .
Referencia número: HY-P9S0124
Synonyms: ORM-6151 Antibody; BMS-986497 Antibody
Target:
Áreas de investigación:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
