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EB 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (1) Eukaryotic Initiation Factor (eIF) (1) Liposome (4) MNK (1) Peptide-Drug Conjugates (PDCs) (1)
By Research Areas:	Cancer (5)
Oligonucleotides:	Pegylated Lipids (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146805

*EB1*	MNK Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
EB1 is the inhibitor of kinases MNK with IC₅₀s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation .

HY-P4118

EB1 peptide Penetrating analog	Amino Acid Derivatives Peptide-Drug Conjugates (PDCs)	Others
EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research .

HY-172726

DSPE-PEG2000-EB1	Liposome	Cancer
DSPE-PEG2000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG2000-EB1 can be used for drug delivery .

HY-172726A

DSPE-PEG3400-EB1	Liposome	Cancer
DSPE-PEG3400-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG3400-EB1 can be used for drug delivery .

HY-172727

DSPE-PEG5000-EB1	Liposome	Cancer
DSPE-PEG5000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG5000-EB1 can be used for drug delivery .

HY-172725

DSPE-PEG1000-EB1	Liposome	Cancer
DSPE-PEG1000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG1000-EB1 can be used for drug delivery .

Cat. No.	Product Name	Type

HY-172726

DSPE-PEG2000-EB1	Biochemical Assay Reagents
DSPE-PEG2000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG2000-EB1 can be used for drug delivery .

HY-172726A

DSPE-PEG3400-EB1	Biochemical Assay Reagents
DSPE-PEG3400-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG3400-EB1 can be used for drug delivery .

HY-172727

DSPE-PEG5000-EB1	Biochemical Assay Reagents
DSPE-PEG5000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG5000-EB1 can be used for drug delivery .

HY-172725

DSPE-PEG1000-EB1	Biochemical Assay Reagents
DSPE-PEG1000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG1000-EB1 can be used for drug delivery .

Cat. No.	Product Name	Target	Research Area

HY-P4118

EB1 peptide Penetrating analog	Amino Acid Derivatives Peptide-Drug Conjugates (PDCs)	Others
EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research .

Host:	Mouse (4)
Reactivity:	Human (3) mouse (1) rat (1) human (1)
Application:	IHC-P (3) ICC/IF (3) IF-Tissue (1) IP (1) WB (2) FC (2) ELISA (1)
Isotype:	IgG1 (1) IgG2a (2) IgG2b (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89719

	EB1 Antibody (YA9063)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	EB1 Antibody (YA9063) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EB1.

HY-P88146

	MAPRE2 (EB2) Antibody (YA7830) EB1; EB2; RP1	IHC-P, ICC/IF, FC	Human
	MAPRE2 (EB2) Antibody (YA7830) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAPRE2 (EB2).

HY-P88146A

	MAPRE2 (EB2) Antibody (YA7830)(PBS only) EB1; EB2; RP1	IHC-P, ICC/IF, FC	Human
	MAPRE2 (EB2) Antibody (YA7830) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAPRE2 (EB2).

HY-P810508

	Phospho-EB3 (Ser162) Antibody (YA9794) EB3, EBF3, MAPRE3, RP/EB Family, RP3, APC binding protein, EB 3, EB1 protein family member 3,	WB, IHC-P	Human
	Phospho-EB3 (Ser162) Antibody (YA9794) is a Mouse-derived and non-conjugated IgG2b Monoclonal antibody, targeting to Phospho-EB3(Ser162).

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Cat. No.	Product Name		Classification

HY-172726

DSPE-PEG2000-EB1		Pegylated Lipids
DSPE-PEG2000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG2000-EB1 can be used for drug delivery .

HY-172726A

DSPE-PEG3400-EB1		Pegylated Lipids
DSPE-PEG3400-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG3400-EB1 can be used for drug delivery .

HY-172727

DSPE-PEG5000-EB1		Pegylated Lipids
DSPE-PEG5000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG5000-EB1 can be used for drug delivery .

HY-172725

DSPE-PEG1000-EB1		Pegylated Lipids
DSPE-PEG1000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG1000-EB1 can be used for drug delivery .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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