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Results for "

FB

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

2

Fluorescent Dyes

3

Inhibitory Antibodies

3

Recombinant Proteins

16

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-127103
    FB23-2
    25+ Cited Publications

    		 Apoptosis Cancer
    FB23-2 is a potent and selective inhibitor of mRNA N 6-methyladenosine (m 6A) demethylase FTO, with an IC50 of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML) .
    FB23-2
  • HY-137187
    FB23
    2 Publications Verification

    		 Fat Mass and Obesity-associated Protein (FTO) Cancer
    FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N 6-methyladenosine (m6A) demethylase activity .
    FB23
  • HY-133894
    Bofutrelvir

    FB2001

    		 SARS-CoV Infection
    Bofutrelvir (FB2001) is a SARS-CoV-2 main protease M pro inhibitor with an IC50 value of 53 nM and an EC50 value of 0.53 μM. Bofutrelvir exhibits potent antiviral efficacy against several current SARS-CoV-2 variants with EC50 values of 0.26-0.42 μM. Bofutrelvir has an additive antiviral effect when combined with Remdesivir (HY-104077) .
    Bofutrelvir
  • HY-156278
    FB49

    		Apoptosis Autophagy Cancer
    FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells .
    FB49
  • HY-148370
    Sefaxersen

    IONIS-FB-LRx; RG6299; ISIS 696844

    		 Complement System Others
    Sefaxersen (IONIS-FB-LRx) is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). Sefaxersen effectively reduces circulating levels of CFB. Sefaxersen can be used for geographic atrophy (GA) research .
    Sefaxersen
  • HY-149334
    ZLD115

    		Fat Mass and Obesity-associated Protein (FTO) Metabolic Disease
    ZLD115 (compound 44) is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). ZLD115 is an antileukemic agent, exhibiting antiproliferative activity against leukemic cell lines .
    ZLD115
  • HY-148370A
    Sefaxersen sodium

    IONIS-FB-LRx sodium; RG6299 sodium; ISIS 696844 sodium

    		 Complement System Others
    Sefaxersen sodium is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). Sefaxersen sodium effectively reduces circulating levels of CFB, and can be used for geographic atrophy (GA) research .
    Sefaxersen sodium
  • HY-178154
    FB231

    		PINK1/Parkin Mitochondrial Metabolism Neurological Disease
    FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease .
    FB231
  • HY-P991256
    FB-825

    		Interleukin Related Inflammation/Immunology
    FB-825 is a human monoclonal antibody (mAb) targeting IGHE. FB-825 targets the CεmX domain of membrane IgE (mIgE), resulting in the downregulation of mIgE-positive B cells and the production of IgE. FB-825 can be used in Allergic asthma, Atopic dermatitis, Job syndrome and Allergic rhinitis research .
    FB-825
  • HY-153412
    KRAS inhibitor-22

    		Ras Cancer
    KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B(G12D) and (G12C), which can be used for cancer research .
    KRAS inhibitor-22
  • HY-W046063
    O-Phthalimide-C3-acid

    4-Phthalimidobutyric acid

    		 Biochemical Assay Reagents Inflammation/Immunology
    4-(N-Phthalimidoyl)butanoic acid (compound FB) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 4-(N-Phthalimidoyl)butanoic acid can be combined with carrier proteins and used in antigen design .
    O-Phthalimide-C3-acid
  • HY-P991287
    FB704A

    		Interleukin Related Inflammation/Immunology
    FB704A is a humanized monoclonal anti-IL6 antibody. FB704A can be used in research related to asthma .
    FB704A
  • HY-RS02557
    CFB Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CFB Human Pre-designed siRNA Set A contains three designed siRNAs for CFB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CFB Human Pre-designed siRNA Set A
    CFB Human Pre-designed siRNA Set A
  • HY-178973
    Microtubule-IN-13

    		Microtubule/Tubulin Cancer
    Microtubule-IN-13 (Compound FB2) is a microtubule inhibitor. Microtubule-IN-13 interferes with microtubule dynamics, leading to defects in the mitotic spindle and persistent mitotic arrest. Microtubule-IN-13 exhibits potent cytotoxicity against multiple cancer cell lines (IC50 = 0.3-2.7 μM). Microtubule-IN-13 can be used for cancer research .
    Microtubule-IN-13
  • HY-P992030
    FB102

    		Transmembrane Glycoprotein Inflammation/Immunology
    FB102 is an anti-human CD122 (IL-2Rβ) monoclonal antibody with selective activity. FB102 blocks the proliferation and activation of pathogenic NK cells and specific T cell subsets induced by IL-2 and IL-15, without affecting the proliferation of regulatory T cells. FB102 inhibits IL-2/IL-15-induced activation of CD4+ and CD8+ T cells in in vitro disease models. FB102 is applicable to research related to celiac disease .
    FB102
  • HY-RS17438
    Cfb Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cfb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cfb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cfb Mouse Pre-designed siRNA Set A
    Cfb Mouse Pre-designed siRNA Set A
  • HY-D3249
    FB

    FB
  • HY-D1236
    Fluorescent brightener 71

    		Parasite Deubiquitinase PARP Cancer
    Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and USP14, as well as a CD40 ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes gpx-4 and sod-4, and reversibly increases the protein levels of UCHL5 and USP14 through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer .
    Fluorescent brightener 71

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