FGF23

By Targets:	Antibiotic (1) ERK (2) FGFR (4) Glycosyltransferase (1) MMP (1) mRNA (1) Reactive Oxygen Species (ROS) (2) Small Interfering RNA (siRNA) (3) Sodium Phosphate Cotransporter (1) TGF-β Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1428C

Ferric citrate 5 Publications Verification Iron(III) citrate; Zerenex	Reactive Oxygen Species (ROS) Antibiotic	Metabolic Disease
Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .

HY-150687

ZINC12409120	ERK	Metabolic Disease
ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting *FGF23:α-Klotho* interaction to inhibit ERK activity with an IC₅₀ of 5.0 μM .

HY-125961

T3Inh-1	FGFR Glycosyltransferase	Cancer
T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC₅₀=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream) .

HY-174698

*Human FGF23* mRNA**	mRNA	Cancer
Human FGF23 mRNA encodes the human fibroblast growth factor 23 (FGF23) protein, a member of the fibroblast growth factor (FGF) family. FGF23 regulates phosphate homeostasis and transport in the kidney.

HY-RS04900

FGF23 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FGF23 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGF23 Human Pre-designed siRNA Set A FGF23 Human Pre-designed siRNA Set A

HY-RS23171

Fgf23 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgf23 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgf23 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgf23 Rat Pre-designed siRNA Set A Fgf23 Rat Pre-designed siRNA Set A

HY-W012856

3-Ethyltoluene 3-Methylethylbenzene	Reactive Oxygen Species (ROS) FGFR TGF-β Receptor MMP	Metabolic Disease
3-Ethyltoluene (3-Methylethylbenzene) is an isomer of Ethyltoluenes. 3-Ethyltoluene inhibits cell survival and proliferation and increases ROS production. 3-Ethyltoluene upregulates cellular inflammatory gene expression. 3-Ethyltoluene induces cell fibrosis with increased level of AST, *FGF-23, Cyt-7 p21, TGFβ, TIMP2, and MMP2*. 3-Ethyltoluene can be used for liver diseases such as NAFLD research .

HY-RS16734

Fgf23 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgf23 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgf23 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgf23 Mouse Pre-designed siRNA Set A Fgf23 Mouse Pre-designed siRNA Set A

HY-183371

ZINC13407541	FGFR	Metabolic Disease
ZINC13407541 is a fibroblast growth factor 23 (FGF23) antagonist with an IC₅₀ of 0.45 μM. ZINC13407541 preferentially binds to the *FGF23:FGFR* interface to disrupt their protein-protein interactions. ZINC13407541 can be used for the research of hypophosphatemia .

HY-186173

MD-3-A45	ERK FGFR	Metabolic Disease
MD-3-A45 is an inhibitor of fibroblast growth factor 23 (FGF-23). MD-3-A45 blocks the activation of the FGFRs/α-klotho signaling pathway by FGF-23 and inhibits FGF-23-induced ERK activation. MD-3-A45 can be used in the research of chronic kidney disease, hereditary hypophosphatemic rickets and acquired hypophosphatemic rickets .

HY-159978

EOS789	Sodium Phosphate Cotransporter	Metabolic Disease Inflammation/Immunology
EOS789 is an orally active sodium-dependent phosphate transporter inhibitor, with IC₅₀ values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC₅₀ values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively. EOS789 inhibits intestinal phosphate absorption, increases fecal phosphate excretion, reduces urinary phosphate excretion, and decreases the levels of serum phosphate, FGF23, and adult parathyroid hormone. EOS789 ameliorates ectopic thoracic aortic calcification, renal injury and hyperphosphatemia, and inhibits the expression of fibrosis markers. EOS789 can be used for the research of hyperphosphatemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9939

Burosumab 1 Publications Verification KRN23; N5KG1_C10_LH; UX-023	Inhibitory Antibodies	Metabolic Disease Cancer
Burosumab (KRN23) is a humanized *FGF23*-neutralizing antibody. By neutralizing *FGF23*, Burosumab blocks its inhibitory effect on renal phosphate reabsorption, thereby increasing serum phosphate levels and improving abnormal bone mineralization. Burosumab can be used in the research of diseases such as X-linked hypophosphatemia (XLH) and osteomalacia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012856

3-Ethyltoluene 3-Methylethylbenzene	Structural Classification Natural Products Plants Anacardium occidentaleL. Anacardiaceae Source Classification	Reactive Oxygen Species (ROS) FGFR TGF-β Receptor MMP
3-Ethyltoluene (3-Methylethylbenzene) is an isomer of Ethyltoluenes. 3-Ethyltoluene inhibits cell survival and proliferation and increases ROS production. 3-Ethyltoluene upregulates cellular inflammatory gene expression. 3-Ethyltoluene induces cell fibrosis with increased level of AST, *FGF-23, Cyt-7 p21, TGFβ, TIMP2, and MMP2*. 3-Ethyltoluene can be used for liver diseases such as NAFLD research .

Recombinant Proteins Recommended:

FGF-23

Species:	Human (3) Mouse (1) Rat (2)
Tag:	His (5) Tag Free (1)
Source:	HEK293 (2) P. pastoris (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78675

	FGF-23 Protein, Human (R179Q, HEK293, His) FGF23; HYPF; FGF-23; ADHR; HPDR2	Human	HEK293
	FGF-23 protein is an important regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It upregulates EGR1 expression through KL, directly reduces PTH secretion, and negatively regulates osteoblast differentiation and matrix mineralization. FGF-23 Protein, Human (R179Q, HEK293, His) is the recombinant human-derived FGF-23 protein, expressed by HEK293 , with C-His labeled tag and R179Q, , , , mutation.

HY-P72195

	FGF-23 Protein, Rat (His) FGF23Fibroblast growth factor 23; FGF-23	Rat	E. coli
	FGF-23 protein is a key regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It also modulates vitamin D metabolism, negatively regulates osteoblast differentiation and matrix mineralization, and reduces parathyroid hormone secretion from the parathyroid glands. FGF-23 Protein, Rat (His) is the recombinant rat-derived FGF-23 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700493

	FGF-23 Protein, Rat (P. pastoris, His) FGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor	Rat	P. pastoris
	FGF-23 protein is a key regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It also modulates vitamin D metabolism, negatively regulates osteoblast differentiation and matrix mineralization, and reduces parathyroid hormone secretion from the parathyroid glands. FGF-23 Protein, Rat (P. pastoris, His) is the recombinant rat-derived FGF-23 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P700064AF

	*Animal-Free FGF-23* Protein, Human (His)** FGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor	Human	E. coli
	FGF-23 protein is an important regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It upregulates EGR1 expression through KL, directly reduces PTH secretion, and negatively regulates osteoblast differentiation and matrix mineralization. Animal-Free FGF-23 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-23 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P702509

	FGF-23 Protein, Mouse (R179Q, HEK293, His) ADHR; FGF23; FGF-23; fibroblast growth factor 23; HPDR2; HYPF; phosphatonin; PHPTC; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor	Mouse	HEK293
	FGF-23 protein is a key regulator that maintains phosphate homeostasis by inhibiting tubular phosphate transport and reducing SLC34A1 levels. It directly inhibits PTH secretion, regulates vitamin D metabolism, and negatively affects osteoblast differentiation and matrix mineralization. FGF-23 Protein, Mouse (R179Q, HEK293, His) is the recombinant mouse-derived FGF-23 protein, expressed by HEK293 , with C-6*His labeled tag and R179Q mutation.

HY-P7013

	FGF-23 Protein, Human 2 Publications Verification rHuFGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor	Human	E. coli
	FGF-23 Protein, Human is a unique FGF subfamily member, acts as a hormone and requires α-Klotho to signal through canonical FGFR, and induces hypertrophy and mineralization during chondrogenesis.

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Cat. No.	Product Name		Classification

HY-174698

*Human FGF23* mRNA**		mRNA
Human FGF23 mRNA encodes the human fibroblast growth factor 23 (FGF23) protein, a member of the fibroblast growth factor (FGF) family. FGF23 regulates phosphate homeostasis and transport in the kidney.

HY-RS04900

FGF23 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FGF23 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23171

Fgf23 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Fgf23 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgf23 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16734

Fgf23 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Fgf23 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgf23 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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