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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
FXI
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "FXI" in MCE Product Catalog:
9
9 Cited Publications
Cat. No.: HY-114164H
CAS No.: 9002-04-4
Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)
Research Areas:
Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.
This product is in a freeze-dried form.
Cat. No.: HY-P99415
CAS No.: 2098724-83-3
Synonyms: MAA868
Target:
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Cat. No.: HY-P99794
CAS No.: 2056878-75-0
Synonyms: BAY 1213790
Target:
Research Areas:
Cat. No.: HY-134005
CAS No.: 1223657-78-0
Synonyms: FXI-ASO; BAY2306001; IONIS-FXIRx
Target:
Research Areas:
ISIS 416858, a single-stranded antisense oligodeoxynucleotide, is a potent and selective inhibitor of FXI mRNA expression.
Cat. No.: HY-175735
CAS No.: 2563884-39-7
Target:
Research Areas:
Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus .
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DNA, d([2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-A-sp-T-sp-T-sp-G-sp-G-sp-T-sp-G-sp-m5C-sp-A-sp-m5C-sp-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rU), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt (1:20)
Synonyms: ION-957943; BAY-2976217; IONIS-FXI-LRx sodium
Cat. No.: HY-P991581
CAS No.: 2812480-88-7
Target:
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Cat. No.: HY-177669
CAS No.: 3061406-99-0
Synonyms: RBD4059
Research Areas:
Vortosiran (RBD4059) is a siRNA that inhibits the synthesis of coagulation factor XI (FXI). Vortosiran shows potent inhibitory activity against mouse FXI transcripts with an IC50 of 69 pM; it exerts similar effects on common FXI transcripts from humans and monkeys, with an IC50 of 59 pM. Vortosiran exhibits antithrombotic activity without impairing hemostatic function. Vortosiran can be used in research related to intravascular thrombosis .
Cat. No.: HY-177669A
Synonyms: RBD4059 sodium
Research Areas:
Vortosiran (RBD4059) sodium is a siRNA that inhibits the synthesis of coagulation factor XI (FXI). Vortosiran sodium shows potent inhibitory activity against mouse FXI transcripts with an IC50 of 69 pM; it exerts similar effects on common FXI transcripts from humans and monkeys, with an IC50 of 59 pM. Vortosiran sodium exhibits antithrombotic activity without impairing hemostatic function. Vortosiran sodium can be used in research related to intravascular thrombosis .
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DNA, d([2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-A-sp-T-sp-T-sp-G-sp-G-sp-T-sp-G-sp-m5C-sp-A-sp-m5C-sp-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rU), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]
Cat. No.: HY-139788
CAS No.: 2380135-03-3
Synonyms: ION-957943 free acid; BAY-3563450; IONIS-FXI-LRx
Cat. No.: HY-RS17241
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F11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for F11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P991006
CAS No.: 2857858-76-3
Synonyms: KN-060
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Cat. No.: HY-P700978
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F11; Plasma Thromboplastin Antecedent; Coagulation Factor XI; Coagualtion Factor XI; FXI; PTA
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P703948
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: F11; Plasma Thromboplastin Antecedent; Coagulation Factor XI; Coagualtion Factor XI; FXI; PTA
Species:
Rabbit
Source:
HEK293
Cat. No.: HY-177669C
Synonyms: FAM labled RBD4059 sodium
Research Areas:
FAM labled Vortosiran sodium (RBD4059) a FAM labled Vortosiran sodium. Vortosiran sodium is a siRNA that inhibits the synthesis of coagulation factor XI (FXI). Vortosiran sodium shows potent inhibitory activity against mouse FXI transcripts with an IC50 of 69 pM; it exerts similar effects on common FXI transcripts from humans and monkeys, with an IC50 of 59 pM. Vortosiran sodium exhibits antithrombotic activity without impairing hemostatic function. Vortosiran sodium can be used in research related to intravascular thrombosis .
Cat. No.: HY-177669D
Synonyms: Cy3 labled RBD4059 sodium
Research Areas:
Cy3 labled Vortosiran (RBD4059) sodium is a Cy3 labled Vortosiran sodium. Vortosiran (RBD4059) sodium is a siRNA that inhibits the synthesis of coagulation factor XI (FXI). Vortosiran sodium shows potent inhibitory activity against mouse FXI transcripts with an IC50 of 69 pM; it exerts similar effects on common FXI transcripts from humans and monkeys, with an IC50 of 59 pM. Vortosiran sodium exhibits antithrombotic activity without impairing hemostatic function. Vortosiran sodium can be used in research related to intravascular thrombosis .
Cat. No.: HY-RS04625
Target:
Research Areas:
F11 Human Pre-designed siRNA Set A contains three designed siRNAs for F11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
