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Fertilization

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (3) Antibiotic (2) Apoptosis (2) Bacterial (2) Biochemical Assay Reagents (4) Calcium Channel (3) CDK (2) Endogenous Metabolite (4) Environmental Pollutants (1) Fungal (3) Glycosidase (1) Isotope-Labeled Compounds (1) Parasite (1) Phospholipase (1) Potassium Channel (2) Prostaglandin Receptor (2) Reference Standards (4) Ser/Thr Protease (1) Sodium Channel (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Endocrinology (4) Infection (4) Inflammation/Immunology (1) Metabolic Disease (5) Neurological Disease (1)

By Targets:

Aldose Reductase (3)

Antibiotic (2)

Apoptosis (2)

Bacterial (2)

Biochemical Assay Reagents (4)

Calcium Channel (3)

CDK (2)

Endogenous Metabolite (4)

Environmental Pollutants (1)

Fungal (3)

Glycosidase (1)

Isotope-Labeled Compounds (1)

Parasite (1)

Phospholipase (1)

Potassium Channel (2)

Prostaglandin Receptor (2)

Reference Standards (4)

Ser/Thr Protease (1)

Sodium Channel (1)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (1)

Endocrinology (4)

Infection (4)

Inflammation/Immunology (1)

Metabolic Disease (5)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0096

Iloprost 5 Publications Verification Ciloprost; ZK 36374	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-W093399

Ammonium bicarbonate,AR,99% 3 Publications Verification	Environmental Pollutants Biochemical Assay Reagents Fungal	Infection
Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields .

HY-108903A

Hyaluronidase, Ovine testes 10+ Cited Publications	Glycosidase Biochemical Assay Reagents	Endocrinology
Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases .

HY-129047E

Trypsin, porcine pancreas (Cell culture grade) Maximum Cited Publications 20 Publications Verification	Ser/Thr Protease	Others
Trypsin, porcine pancreas (Cell culture grade) is a serine protease that hydrolyzes proteins at the carboxyl side of lysine or arginine residues. Trypsin, porcine pancreas (Cell culture grade) exhibits excellent protein digestibility for α-lactalbumin and β-casein. Trypsin, porcine pancreas (Cell culture grade) removes cellular components while preserving extracellular matrix structures to achieve uniform decellularization of porcine pancreas .

HY-104013

Aminopurvalanol A 1 Publications Verification	CDK Apoptosis	Cancer
Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization .

HY-175728

VU6032735	Potassium Channel Sodium Channel Calcium Channel	Metabolic Disease
VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC₅₀ values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception .

HY-B1202

Alrestatin 1 Publications Verification AY-22284	Aldose Reductase	Metabolic Disease
Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases .

HY-164911

VU0546110	Potassium Channel	Endocrinology
VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC₅₀s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K ⁺ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential .

HY-P5351A

Hyaluronan-binding peptide, biotin labeled TFA	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Hyaluronan-binding peptide, biotin labeled TFA is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.) .

HY-121473

Aklavin	Antibiotic Bacterial Fungal Parasite	Infection
Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene .

HY-A0096R

Iloprost (Standard) Ciloprost (Standard); ZK 36374 (Standard)	Reference Standards Prostaglandin Receptor Endogenous Metabolite	Endocrinology Cancer
Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-W795960

D-myo-Inositol 1,4,5-trisphosphate sodium salt	Biochemical Assay Reagents Calcium Channel Phospholipase	Neurological Disease Metabolic Disease
D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P₃ receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and Ca ²⁺-ATPase activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

HY-W093399S

Ammonium bicarbonate-15N	Isotope-Labeled Compounds Biochemical Assay Reagents Fungal	Infection
Ammonium bicarbonate- ¹⁵N is the ¹⁵N labeled isotope of Ammonium bicarbonate,AR,99% (HY-W093399). Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields .

HY-P10785

Iturin A-2	Bacterial Antibiotic	Infection
Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC₅₀ values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs .

HY-P3710

Ser-Ala-alloresact	Calcium Channel	Others
Ser-Ala-alloresact is a sperm activating peptide (SAP). The peptides released from eggs of marine invertebrates play a central role in fertilization .

HY-B1202A

Alrestatin sodium AY-22284A	Aldose Reductase	Metabolic Disease
Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases .

HY-B1202R

Alrestatin (Standard) AY-22284 (Standard)	Reference Standards Aldose Reductase	Metabolic Disease
Alrestatin (AY-22284) Standard is the analytical standard of Alrestatin (HY-B1202). This product is intended for research and analytical applications. Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases.

HY-N8321R

5-O-Caffeoylshikimic acid (Standard)	Reference Standards Others	Cancer
Insect repellent M 3535 (Standard) is the analytical standard of Insect repellent M 3535. This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a novel potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

HY-104013R

Aminopurvalanol A (Standard)	Reference Standards CDK Apoptosis	Cancer
Aminopurvalanol A (Standard) is the analytical standard of Aminopurvalanol A (HY-104013). This product is intended for research and analytical applications. Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization .

HY-131511

Rovicurt Permethrin-tetramethrin mixture	Endogenous Metabolite	Others
Rovicurt (Permethrin-tetramethrin mixture) is a pesticide that has the activity of stimulating biological adaptation mechanisms. Rovicurt increases the diameter of seminiferous tubules and the number of Sertoli cells. Rovicurt also improves the fertilizing ability of sperm .

HY-Z11709

13-Hydroxy-alpha-tocopherol	Endogenous Metabolite	Cancer
13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma .

Cat. No.	Product Name	Type

HY-W093399

Ammonium bicarbonate,AR,99% 3 Publications Verification	Biochemical Assay Reagents
Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields .

HY-W795960

D-myo-Inositol 1,4,5-trisphosphate sodium salt	Biochemical Assay Reagents
D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P₃ receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and Ca ²⁺-ATPase activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

D-myo-Inositol 1,4,5-trisphosphate sodium salt

Biochemical Assay Reagents

D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P₃ receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and Ca ²⁺-ATPase activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

Cat. No.	Product Name	Target	Research Area

HY-P5351A

Hyaluronan-binding peptide, biotin labeled TFA	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Hyaluronan-binding peptide, biotin labeled TFA is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.) .

HY-P5351

Hyaluronan-binding peptide, biotin labeled	Peptides	Others
Hyaluronan-binding peptide, biotin labeled is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.)

HY-P10785

Iturin A-2	Bacterial Antibiotic	Infection
Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC₅₀ values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs .

HY-P3710

Ser-Ala-alloresact	Calcium Channel	Others
Ser-Ala-alloresact is a sperm activating peptide (SAP). The peptides released from eggs of marine invertebrates play a central role in fertilization .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0096

Iloprost 5 Publications Verification Ciloprost; ZK 36374	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Prostaglandin Receptor Endogenous Metabolite
Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-A0096R

Iloprost (Standard) Ciloprost (Standard); ZK 36374 (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Prostaglandin Receptor Endogenous Metabolite
Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-N8321R

5-O-Caffeoylshikimic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Phenols Polyphenols Plants Source Classification	Reference Standards Others
Insect repellent M 3535 (Standard) is the analytical standard of Insect repellent M 3535. This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a novel potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

HY-Z11709

13-Hydroxy-alpha-tocopherol	Structural Classification Natural Products Garcinia kola Heckel Guttiferae Plants Source Classification	Endogenous Metabolite
13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma .

Cat. No.	Product Name	Chemical Structure

HY-W093399S

Ammonium bicarbonate-15N
Ammonium bicarbonate- ¹⁵N is the ¹⁵N labeled isotope of Ammonium bicarbonate,AR,99% (HY-W093399). Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields .

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Fertilization

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