Fn14

Isoforms Recommended:	TNFRSF12A/TWEAK

By Targets:	Apoptosis (1) Influenza Virus (1) MicroRNA (1) NF-κB (1) P2X Receptor (1) Small Interfering RNA (siRNA) (3) STAT (1) TNF Receptor (4) Topoisomerase (1)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-113763

L524-0366	TNF Receptor	Others
L524-0366 is a specific, dose-dependent TWEAK-Fn14 inhibitor. L524-0366 specifically binds to the Fn14 surface with a K_D of 7.12 μM, competitively inhibiting the binding of Fn14 to TWEAK (inhibition rate reaching 16%). L524-0366 inhibits TWEAK-induced glioma cell migration without potential cytotoxic effects .

HY-122575

Aurintricarboxylic acid 3 Publications Verification	P2X Receptor Influenza Virus Topoisomerase MicroRNA Apoptosis	Infection Neurological Disease Inflammation/Immunology
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC₅₀s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase . Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the *TWEAK-Fn14* signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC₅₀ of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC₅₀ of 0.47 µM .

HY-P991433

BIIB036	TNF Receptor	Cancer
BIIB036 is a human IgG1 monoclonal antibody (mAb) targeting *TNFRSF12A/Fn14*. BIIB036 inhibits the growth of patient-derived primary colorectal tumors in SCID mice .

HY-RS14803

TNFRSF12A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFRSF12A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNFRSF12A Human Pre-designed siRNA Set A TNFRSF12A Human Pre-designed siRNA Set A

HY-RS17480

Tnfrsf12a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf12a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf12a Mouse Pre-designed siRNA Set A Tnfrsf12a Mouse Pre-designed siRNA Set A

HY-RS23938

Tnfrsf12a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf12a Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf12a Rat Pre-designed siRNA Set A Tnfrsf12a Rat Pre-designed siRNA Set A

HY-P992321

BAY-356	TNF Receptor NF-κB STAT	Cancer
BAY-356, a potent TWEAK receptor agonist, is an aglycosylated anti-TWEAK receptor antibody. BAY-356 triggers TWEAKR hyperactivation, activates NFκB and STAT1 pathways, and undergoes TWEAKR-dependent internalization. BAY-356 can be used for the research of colorectal cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer^[1]^[2].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P991433

BIIB036	TNF Receptor	Cancer
BIIB036 is a human IgG1 monoclonal antibody (mAb) targeting *TNFRSF12A/Fn14*. BIIB036 inhibits the growth of patient-derived primary colorectal tumors in SCID mice .

HY-P992321

BAY-356	TNF Receptor NF-κB STAT	Cancer
BAY-356, a potent TWEAK receptor agonist, is an aglycosylated anti-TWEAK receptor antibody. BAY-356 triggers TWEAKR hyperactivation, activates NFκB and STAT1 pathways, and undergoes TWEAKR-dependent internalization. BAY-356 can be used for the research of colorectal cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer^[1]^[2].

Species:	Human (2) Mouse (1)
Tag:	Tag Free (1) Fc (2)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72435

	TNFRSF12A Protein, Mouse (HEK293, Fc) TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; Fn14; CD266 antigen and tweak-receptor	Mouse	HEK293
	TNFRSF12A Protein, a receptor for TNFSF12/TWEAK, exhibits a weak apoptosis-inducing ability in specific cells.It promotes angiogenesis and endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins.In functional interactions, TNFRSF12A associates with TRAF1 and TRAF2, possibly with TRAF3, suggesting its involvement in signaling pathways contributing to diverse cellular processes.TNFRSF12A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TNFRSF12A protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72434

	TNFRSF12A Protein, Human (HEK293, Fc) 1 Publications Verification TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; Fn14; CD266 antigen and tweak-receptor	Human	HEK293
	TNFRSF12A Protein, the receptor for TNFSF12/TWEAK, acts as a weak apoptosis inducer in specific cell types. It also promotes angiogenesis, endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins. Association with TRAF1, TRAF2, and potentially TRAF3 underscores its involvement in diverse cellular signaling pathways. TNFRSF12A Protein, Human (HEK293, Fc) is the recombinant human-derived TNFRSF12A protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71909

	TNFRSF12A Protein, Human CD 266; CD266; CD266 antigen; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; Fn 14; Fn14; TNFRSF 12A; TNFRSF12A; TNR12_HUMAN; Tumor necrosis factor receptor superfamily member 12A; TWEAK R; Tweak receptor; Tweak-receptor; TweakR	Human	E. coli
	TNFRSF12A Protein, the receptor for TNFSF12/TWEAK, acts as a weak apoptosis inducer in specific cell types. It also promotes angiogenesis, endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins. Association with TRAF1, TRAF2, and potentially TRAF3 underscores its involvement in diverse cellular signaling pathways. TNFRSF12A Protein, Human is the recombinant human-derived TNFRSF12A protein, expressed by E. coli , with tag free.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (1) IF-Tissue (1) IP (3) WB (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810450

	TNFSF12 Antibody (YA9755) Fn14, TNFRSF 12A, Tweak receptor, TweakR,	WB, IHC-P, ICC/IF, IF-Tissue, IP	Human, Mouse, Rat
	TNFSF12 Antibody (YA9755) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to TNFSF12.

HY-P82931

	CD266 Antibody (YA2676) CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fn14; TNFRSF 12A; Tweak receptor; TweakR	WB, IHC-P, IP	Human, Mouse, Rat
	CD266 Antibody (YA2676) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD266.

HY-P82931A

	CD266 Antibody (YA2676)(PBS only) CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fn14; TNFRSF 12A; Tweak receptor; TweakR	WB, IHC-P, IP	Human, Mouse, Rat
	CD266 Antibody (YA2676) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD266.

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Cat. No.	Product Name		Classification

HY-RS14803

TNFRSF12A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNFRSF12A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17480

Tnfrsf12a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tnfrsf12a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23938

Tnfrsf12a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tnfrsf12a Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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