GCLC

By Targets:	AMPK (1) Caspase (2) Drug Derivative (1) Ferroptosis (3) Fungal (2) Glutathione Peroxidase (3) Glycosidase (1) IKK (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (1) Keap1-Nrf2 (4) LDLR (3) NO Synthase (1) p38 MAPK (1) PARP (2) Reactive Oxygen Species (ROS) (4) Reference Standards (2) Small Interfering RNA (siRNA) (3) α-synuclein (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015600

2-Acetamidophenol Orthocetamol	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR	Cardiovascular Disease Inflammation/Immunology
2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC₅₀s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe ²⁺), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-N1970

5,7-Dihydroxychromone 2 Publications Verification	Keap1-Nrf2 Caspase PARP Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, *GCLc.* 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .

HY-171705

KMS99220	Keap1-Nrf2 AMPK JNK IKK p38 MAPK NO Synthase α-synuclein Interleukin Related	Neurological Disease
KMS99220 is an orally active, blood-brain barrier-permeable activator of the Nrf2 inhibitory protein Keap-1. KMS99220 enhances the activity of AMPK, activates the Nrf2 signaling pathway, and reduces the phosphorylation of IκB, nuclear translocation of NFκB, as well as the phosphorylation levels of JNK, IKK and p38 MAPK via HO-1. KMS99220 binds to Keap1 to trigger the nuclear translocation of Nrf2, induces the expression of HO-1, NQO1, *GCLC, GCLM* and proteasome subunits; enhances proteasomal enzymatic activity; inhibits iNOS expression, nitric oxide production and IL-1β generation; attenuates microglial activation; reduces α-synuclein aggregation; and prevents dopaminergic neuron degeneration and motor dysfunction. KMS99220 prevents the degeneration of dopaminergic neurons in the substantia nigra, induces the expression of Nrf2 downstream target genes, and effectively ameliorates associated motor dysfunction in a mouse model of Parkinson's disease. KMS99220 is applicable to research related to Parkinson's disease .

HY-W015600R

2-Acetamidophenol (Standard) Orthocetamol (Standard)	Reference Standards Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR	Cardiovascular Disease Inflammation/Immunology
2-Acetamidophenol (Standard) is the analytical standard of 2-Acetamidophenol. This product is intended for research and analytical applications. 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC₅₀s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe ²⁺), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-RS05333

GCLC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GCLC Human Pre-designed siRNA Set A contains three designed siRNAs for GCLC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GCLC Human Pre-designed siRNA Set A GCLC Human Pre-designed siRNA Set A

HY-W015600S

2-Acetamidophenol-d3 Orthocetamol-d₃	Isotope-Labeled Compounds Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR	Cardiovascular Disease Inflammation/Immunology
2-Acetamidophenol-d₃ (Orthocetamol-d₃) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-RS17688

Gclc Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gclc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gclc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gclc Mouse Pre-designed siRNA Set A Gclc Mouse Pre-designed siRNA Set A

HY-N1970R

5,7-Dihydroxychromone (Standard)	Reference Standards Keap1-Nrf2 Caspase PARP Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, *GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα* and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .

HY-RS24150

Gclc Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gclc Rat Pre-designed siRNA Set A contains three designed siRNAs for Gclc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gclc Rat Pre-designed siRNA Set A Gclc Rat Pre-designed siRNA Set A

HY-N17855

Guavinoside B	Glycosidase Reactive Oxygen Species (ROS)	Metabolic Disease
Guavinoside B is an orally active α-glucosidase inhibitor with an IC₅₀ of 0.21 mM. Guavinoside B upregulates the expressions of Nrf2, GCLC and NQO1 induced by Acetaminophen (HY-66005), downregulates the expression of p-JNK, and reduces intracellular ROS levels. Guavinoside B decreases serum TNF-α levels induced by Acetaminophen, alleviates hepatocellular infiltration and necrosis, and improves liver-related biochemical parameters. Guavinoside B is applicable to the research of diabetes and Acetaminophen-induced liver injury .

HY-N17732

7-Hydroxy-5,3'4'-trimethoxyflavanone	Drug Derivative	Inflammation/Immunology
7-Hydroxy-5,3',4'-trimethoxyflavanone (Compound AG2) is a key flavanone derivative obtained from the hydrolysis of Methyl-Hesperidin (HY-N0165). 7-Hydroxy-5,3',4'-trimethoxyflavanone exhibits only weak Nrf2-ARE activation activity and is insufficient to initiate the cellular antioxidant defense system .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1970

5,7-Dihydroxychromone 2 Publications Verification	Structural Classification Flavonoids other families Phenols Polyphenols Plants Isoflavones Source Classification	Keap1-Nrf2 Caspase PARP Fungal
5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, *GCLc.* 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .

HY-N1970R

5,7-Dihydroxychromone (Standard)	Structural Classification Flavonoids other families Phenols Polyphenols Plants Isoflavones Source Classification	Reference Standards Keap1-Nrf2 Caspase PARP Fungal
5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, *GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα* and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .

HY-N17855

Guavinoside B	Structural Classification Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants Source Classification	Glycosidase Reactive Oxygen Species (ROS)
Guavinoside B is an orally active α-glucosidase inhibitor with an IC₅₀ of 0.21 mM. Guavinoside B upregulates the expressions of Nrf2, GCLC and NQO1 induced by Acetaminophen (HY-66005), downregulates the expression of p-JNK, and reduces intracellular ROS levels. Guavinoside B decreases serum TNF-α levels induced by Acetaminophen, alleviates hepatocellular infiltration and necrosis, and improves liver-related biochemical parameters. Guavinoside B is applicable to the research of diabetes and Acetaminophen-induced liver injury .

HY-N17732

7-Hydroxy-5,3'4'-trimethoxyflavanone	Structural Classification Flavonoids Microorganisms Flavonones Source Classification	Drug Derivative
7-Hydroxy-5,3',4'-trimethoxyflavanone (Compound AG2) is a key flavanone derivative obtained from the hydrolysis of Methyl-Hesperidin (HY-N0165). 7-Hydroxy-5,3',4'-trimethoxyflavanone exhibits only weak Nrf2-ARE activation activity and is insufficient to initiate the cellular antioxidant defense system .

Cat. No.	Product Name	Chemical Structure

HY-W015600S

2-Acetamidophenol-d3
2-Acetamidophenol-d₃ (Orthocetamol-d₃) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

2-Acetamidophenol-d3

2-Acetamidophenol-d₃ (Orthocetamol-d₃) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	ICC/IF (1) IP (1) WB (3) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86305

	GCLC Antibody (YA5997) GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GCLC Antibody (YA5997) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

HY-P83153

	GCLC Antibody (YA2898) GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB	Human, Mouse, Rat
	GCLC Antibody (YA2898) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

HY-P83153A

	GCLC Antibody (YA2898)(PBS only) GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB	Human, Mouse, Rat
	GCLC Antibody (YA2898) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

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Cat. No.	Product Name		Classification

HY-RS05333

GCLC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GCLC Human Pre-designed siRNA Set A contains three designed siRNAs for GCLC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17688

Gclc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gclc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gclc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24150

Gclc Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gclc Rat Pre-designed siRNA Set A contains three designed siRNAs for Gclc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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