31 Results for "

GDF15

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "GDF15" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-P99241
CAS No.: 2368950-15-4
Synonyms: PF 06946860

Research Areas:  

Cancer

Ponsegromab is a Growth differentiation factor 15 (GDF15) inhibitor with human, cynomolgus monkey, and mouse target IC50 values of 0.123 nM, 0.053 nM, and 0.102 nM, respectively . Ponsegromab acts as a chemosensitizer, increases intracellular reactive oxygen species, reduces glutathione levels . Ponsegromab can be used for the research of oxaliplatin-resistant colorectal cancer .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P77945
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P99100
CAS No.: 2556646-63-8
Synonyms: CTL-002

Research Areas:  

Cancer

Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P75170
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Human
Source:  
P. pastoris
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P75171
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P990635

Target:  

TGF-β Receptor

Research Areas:  

Cancer

NGM-120 is a fully humanized IgG1 monoclonal antibody targeting GFRAL, which functions by blocking the GDF15-GFRAL axis. NGM-120 reduces serum GDF15 levels, increases body weight, expands central memory and proliferative CD8 + T cell populations, and decreases immunosuppressive and naive regulatory T cell populations. NGM-120 can be used for research on advanced prostate cancer .
loading...
    loading...
Cat. No.: HY-RS16542
Research Areas:  

Others

Gdf15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gdf15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-149406
CAS No.: 431920-24-0
Purity:  99.68%
Target:  

AMPK TGF-β Receptor

Research Areas:  

Cancer

AMPK activator 12 (compound 21) is a potent AMPK activator and GDF15 inducer. AMPK activator 12 increases GDF15 protein levels in human hepatic cells .
loading...
    loading...
Cat. No.: HY-P991190
CAS No.: 2894138-72-6
Synonyms: AV-380

Research Areas:  

Cancer

Rilogrotug (AV-380) is a humanized IgG1 monoclonal antibody targeting GDF15 .
loading...
    loading...
Cat. No.: HY-RS05352
Research Areas:  

Others

GDF15 Human Pre-designed siRNA Set A contains three designed siRNAs for GDF15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS22974
Research Areas:  

Others

Gdf15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gdf15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-124956
CAS No.: 957136-80-0
Research Areas:  

Metabolic Disease

GIV3727 is an orally active bitter taste receptor antagonist targeting TAS2R4, TAS2R7, TAS2R20, TAS2R31, TAS2R40, and TAS2R43, with orthosteric, insurmountable antagonism at hTAS2R31. GIV3727 blocks TAS2R4 and prevents Gallic acid-induced upregulation of GDF15 mRNA expression. GIV3727 inhibits agonist-evoked receptor activation. GIV3727 reduces the perceived bitterness of acesulfame K and saccharin without affecting sweet taste perception. GIV3727 can be used for obesity research .
loading...
    loading...
Cat. No.: HY-P99100A
CAS No.: 2556646-63-8
Synonyms: CLT-002 (Powder)

Research Areas:  

Cancer

Visugromab (CTL-002) (Powder) is a GDF-15 neutralizing IgG4 mAb. Visugromab (Powder) has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
loading...
    loading...
Cat. No.: HY-P700293
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P77945A
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P706008
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P77682
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Cynomolgus
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P77946
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P77681
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Cynomolgus
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P700726
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
Species:  
Canine
Source:  
E. coli
loading...
    loading...