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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
GEM
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "GEM" in MCE Product Catalog:
Cat. No.: HY-143411
CAS No.: 2487526-28-1
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GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts .
Cat. No.: HY-149906
CAS No.: 153021-75-1
Synonyms: GEM91
Trecovirsen (GEM91) is an antiviral agent targeting HIV gag mRNA, which hybridizes with complementary HIV gag mRNA at the initiation site. Trecovirsen induces a reversible, dose-dependent prolongation of activated partial thromboplastin time via its polyanionic property. Trecovirsen is applicable to research related to HIV infection .
Cat. No.: HY-149906C
Purity: 98.83%
Synonyms: GEM91 sodium
Trecovirsen sodium is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.
Cat. No.: HY-146540
CAS No.: 2233543-49-0
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GEM-5 is a gemcitabine-based conjugate containing a HIF-1α inhibitor (YC-1) (IC50=30 nM). GEM-5 can significantly down-regulate the expression of HIF-1α and up-regulate the expression of tumor suppressor p53. GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth .
Cat. No.: HY-145441
CAS No.: 2866211-93-8
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GEM–IB is the conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB). GEM–IB as a single agent or in combination with Docetaxel (DTX) demonstrates reduced tumor burden, preservation of the bone architecture, and improved the survival in a murine model of osteosarcoma (OS) .
Cat. No.: HY-154842
CAS No.: 2169925-98-6
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S-Gem is a TrxR-dependent prodrug of Gemcitabine (HY-17026) and selectively activated by TrxR. S-Gem shows less cytotoxicity compared to Gemcitabine .
Cat. No.: HY-RS05366
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GEM Human Pre-designed siRNA Set A contains three designed siRNAs for GEM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16833
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Gem Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gem gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-148827
CAS No.: 255810-66-3
Synonyms: HYBO-165
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
Cat. No.: HY-148827A
Synonyms: HYBO-165 sodium
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
Cat. No.: HY-RS05523
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GMNN Human Pre-designed siRNA Set A contains three designed siRNAs for GMNN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-149906A
Synonyms: FITC-GEM91 sodium
FITC-Trecovirsen (sodium) is a FITC labeled Trecovirsen. Trecovirsen is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene .
Cat. No.: HY-148827D
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FAM labled GEM-231 sodiumis a FAM labled GEM-231 sodium.
Cat. No.: HY-148827E
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Cy3 labled GEM-231 sodium is a Cy3 labled GEM-231 sodium.
Cat. No.: HY-148827C
GEM-231 sodium scrambled negative control is the sequence scrambled negative control of GEM-231 sodium.
Cat. No.: HY-185323
CAS No.: 849139-19-1
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Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme .
Cat. No.: HY-182898
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Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence .
Cat. No.: HY-RS23275
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Gem Rat Pre-designed siRNA Set A contains three designed siRNAs for Gem gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
