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Results for "

Glycolysis inhibition

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AIM2 (2) Apoptosis (3) Biochemical Assay Reagents (2) Caspase (2) Chloride Channel (2) Exosomes (2) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) HIV (2) Isotope-Labeled Compounds (1) NF-κB (2) Oxidative Phosphorylation (1) PD-1/PD-L1 (1) PDK-1 (1) PROTACs (1) PTEN (1) Pyroptosis (2) Pyruvate Kinase (6) Reactive Oxygen Species (ROS) (1) Reference Standards (3) STAT (2) TNF Receptor (2)
By Research Areas:	Cancer (10) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (4)

By Targets:

AIM2 (2)

Apoptosis (3)

Biochemical Assay Reagents (2)

Caspase (2)

Chloride Channel (2)

Exosomes (2)

Hexokinase (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Acetyltransferase (1)

HIV (2)

Isotope-Labeled Compounds (1)

NF-κB (2)

Oxidative Phosphorylation (1)

PD-1/PD-L1 (1)

PDK-1 (1)

PROTACs (1)

PTEN (1)

Pyroptosis (2)

Pyruvate Kinase (6)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

STAT (2)

TNF Receptor (2)

By Research Areas:

Cancer (10)

Inflammation/Immunology (3)

Metabolic Disease (2)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0822

Shikonin 65+ Cited Publications C.I. 75535; Isoarnebin 4	Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-D0849

Sodium iodoacetate 2 Publications Verification Iodoacetic acid sodium salt	Biochemical Assay Reagents	Metabolic Disease Inflammation/Immunology
Sodium iodoacetate is a specific inhibitor of GAPDH and has glycolysis inhibitory activity. In addition, sodium iodoacetate can induce osteoarthritis and related pain models in experimental animals .

HY-B0404A

Benserazide hydrochloride 5+ Cited Publications Ro 4-4602 hydrochloride	Pyruvate Kinase	Neurological Disease Cancer
Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

HY-N6940

Prosapogenin A Progenin III	Apoptosis Caspase Pyroptosis STAT	Cancer
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .

HY-121275

Benserazide 5+ Cited Publications Ro 4-4602	Pyruvate Kinase	Neurological Disease Cancer
Benserazide is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide is also a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the study of Parkinson's disease and melanoma .

HY-P2862

Enolase, S.cerevisiae	Biochemical Assay Reagents	Others
Enolase is a glycolytic enzyme present in the cell wall of S. cerevisiae. Enolase exhibits specific affinity to imported tRNA and can facilitate formation of preMsk1p-tRNA complex. Enolase can be overproduced in tumor cells where rate of glycolysis is increased. Enolase depletion can lead to tRNA inhibition in vivo .

HY-178360

NP1192	PROTACs Histone Acetyltransferase HIF/HIF Prolyl-Hydroxylase PD-1/PD-L1 PTEN	Metabolic Disease Inflammation/Immunology Cancer
NP1192 is a potent, selective PROTAC NAT10 degrader that depletes NAT10 protein and inhibits ac4C modification in cancer cells. NP1192 demonstrates dual inhibition of hypoxia-driven glycolysis and immunosuppression via NAT10/HIF-1α/PD-L1 axis disruption, achieving superior antitumor efficacy and synergizing with anti-PD-L1 both in vitro and in vivo. NP1192 can be used for ovarian, cervical, and glioblastoma cancer research. (Blue: CRBN ligand (HY-148834); Black: linker; Pink: NAT10 ligand (HY-16706)) .

HY-B0404AR

Benserazide hydrochloride (Standard) Ro 4-4602 hydrochloride (Standard)	Reference Standards Pyruvate Kinase	Neurological Disease Cancer
Benserazide hydrochloride (Standard) (Serazide (Standard)) is the analytical standard of Benserazide hydrochloride (HY-B0404A). This product is intended for research and analytical applications. Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

HY-N0822R

Shikonin (Standard) C.I. 75535 (Standard); Isoarnebin 4 (Standard)	Reference Standards Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-B0404AS

Benserazide-d3 hydrochloride Ro 4-4602-d3 hydrochloride	Isotope-Labeled Compounds Pyruvate Kinase	Neurological Disease Cancer
Benserazide-d₃ (hydrochloride) is the deuterium labeled Benserazide hydrochloride (HY-B0404A). Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

HY-N6940R

Prosapogenin A (Standard) Progenin III (Standard)	Reference Standards Apoptosis Caspase Pyroptosis STAT	Cancer
Prosapogenin A (Standard) is the analytical standard of Prosapogenin A. This product is intended for research and analytical applications. Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .

HY-183809

ZSW	Hexokinase	Inflammation/Immunology
ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC₅₀ of 0.48 μM, human HK2 K_a of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease .

HY-179501

PDK1-IN-5	PDK-1 Reactive Oxygen Species (ROS) Apoptosis Oxidative Phosphorylation	Cancer
PDK1-IN-5 is a selective PDK1 inhibitor. PDK1-IN-5 activaties PDH by diminishing phosphorylation level via PDK1 inhibition. PDK1-IN-5 effectively reverses the Warburg effect and shifts cellular energy metabolism from glycolysis toward oxidative phosphorylation by increased acetyl-CoA, reduced lactate, elevated mitochondrial ROS, and subsequent induction of apoptosis. PDK1-IN-5 robustly inhibits tumor growth in vivo without inducing systemic toxicity. PDK1-IN-5 can be used for lung adenocarcinoma, human non-small cell lung adenocarcinoma and gastric colorectal .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0822

Shikonin 65+ Cited Publications C.I. 75535; Isoarnebin 4	Quinones Structural Classification Classification of Application Fields Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae Disease Research Fields Cancer	Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-N6940

Prosapogenin A Progenin III	Veratrum nigrum Linn. other families Liliaceae Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	Apoptosis Caspase Pyroptosis STAT
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .

HY-N0822R

Shikonin (Standard) C.I. 75535 (Standard); Isoarnebin 4 (Standard)	Quinones Structural Classification Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae	Reference Standards Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-N6940R

Prosapogenin A (Standard) Progenin III (Standard)	Structural Classification Veratrum nigrum Linn. other families Liliaceae Plants Steroids Source Classification	Reference Standards Apoptosis Caspase Pyroptosis STAT
Prosapogenin A (Standard) is the analytical standard of Prosapogenin A. This product is intended for research and analytical applications. Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .

Cat. No.	Product Name	Chemical Structure

HY-B0404AS

Benserazide-d3 hydrochloride
Benserazide-d₃ (hydrochloride) is the deuterium labeled Benserazide hydrochloride (HY-B0404A). Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

Benserazide-d3 hydrochloride

Benserazide-d₃ (hydrochloride) is the deuterium labeled Benserazide hydrochloride (HY-B0404A). Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

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