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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
HSC-T6 hepatic stellate cells
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "HSC-T6 hepatic stellate cells" in MCE Product Catalog:
Research Areas:
Biotin-cholesterol is a biotinylated form of Cholesterol (HY-N0322). Biotin-cholesterol is a liver-targeting ligand (linking cholesterol and biotin via a Gly-Lys dipeptide linker), as well as an enhancer of the component activity of streptavidin-mediated siRNA nanocomplexes. Biotin-cholesterol promotes receptor-mediated endocytosis of the relevant siRNA nanocomplexes, protects siRNA from serum degradation, enables efficient siRNA delivery, and drives target gene silencing. Biotin-cholesterol shows no cytotoxicity in hepatic stellate cells. Biotin-cholesterol can be used in the research of alcoholic liver fibrosis .
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Cat. No.: HY-W654334
Cat. No.: HY-W587806
CAS No.: 22737-97-9
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9-cis Retinol is an upstream precursor of 9-cis-Retinal (HY-W009310) and 9-cis-Retinoic acid (HY-15128). 9-cis Retinol serves as a reaction substrate for cRDH, ARAT and LRAT, participates in cellular uptake and isomerization processes, and can be oxidized to form 9-cis-Retinal in the biosynthetic pathway. 9-cis Retinol inhibits the activity of 9-cis retinaldehyde dehydrogenase, thereby blocking the biosynthesis of 9-cis-Retinoic acid. 9-cis Retinol is applicable for metabolism-related research .
Cat. No.: HY-N4215
CAS No.: 104109-37-7
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Triterpenes Terpenoids Plants Umbelliferae Disease Research Fields Inflammation/Immunology Carphephorus corymbosus (Nutt.) Torr. & A.Gray
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Cat. No.: HY-N16980
CAS No.: 2292113-33-6
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Cat. No.: HY-N8032
CAS No.: 1781226-44-5
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Cat. No.: HY-184378
CAS No.: 2922221-22-3
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MDB5 is a Hedgehog pathway and Smoothened inhibitor that binds to the 7-TM domain of Smo . MDB5 reduces hepatic stellate cell activation, extracellular matrix-related gene expression, collagen deposition, hydroxyproline content and epithelial-mesenchymal transition, and prevents sinusoidal endothelial cell capillarization . MDB5 induces G1 and S phase cell cycle arrest, triggers apoptosis by upregulating Bax and downregulating Bcl-2, and also decreases oxygen consumption rate, glucose uptake, transglutaminase activity and fibronectin matrix assembly . MDB5 reduces the levels of liver injury markers, hepatic triglyceride deposition and hepatic steatosis, restores the tissue structure of the kidney and spleen, and inhibits pancreatic tumor growth without causing body weight loss . MDB5 can be loaded into PEG-PCC-g-DC micelles, achieving high drug loading, sustained release, improved water solubility, enhanced cellular uptake and optimized hepatic distribution, with good tolerance in mice . MDB5 is applicable to research related to alcohol-associated liver disease, liver fibrosis and pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
