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Isoforms Recommended:	HSP40

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Hsp40

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (5) Parasite (1) Reference Standards (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (4) Infection (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

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Oligonucleotides

Targets Recommended: Hsp-targeting Chimeras HSP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100110

KNK437 5+ Cited Publications Heat Shock Protein Inhibitor I	HSP	Cancer
KNK437 is a *HSP* inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

HY-18669

ML346 5+ Cited Publications	HSP	Cancer
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

HY-124805

MAL3-101	HSP	Cancer
MAL3-101 is a potent *HSP70* allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) .

HY-126601

Malonganenone A	Parasite HSP	Infection
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x .

HY-100110R

KNK437 (Standard) Heat Shock Protein Inhibitor I (Standard)	HSP Reference Standards	Cancer
KNK437 (Standard) is the analytical standard of KNK437 (HY-100110). This product is intended for research and analytical applications. KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

HY-RS03861

DNAJB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DNAJB1 Human Pre-designed siRNA Set A contains three designed siRNAs for DNAJB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DNAJB1 Human Pre-designed siRNA Set A DNAJB1 Human Pre-designed siRNA Set A

HY-RS03862

Dnajb1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnajb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnajb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnajb1 Mouse Pre-designed siRNA Set A Dnajb1 Mouse Pre-designed siRNA Set A

Malonganenone A	Infection Alkaloids Classification of Application Fields Animals Other Alkaloids Disease Research Fields Source Classification	Parasite HSP
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70331

	HSP40/DNAJB1 Protein, Human (His) 1 Publications Verification rHuDnaJ homolog subfamily B member 1/Hsp40, His; DnaJ Homolog Subfamily B Member 1; DnaJ Protein Homolog 1; Heat Shock 40 kDa Protein 1; Hsp40; Heat Shock Protein 40; Human DnaJ Protein 1; hDj-1; DNAJB1; DNAJ1; HDJ1; HspF1	Human	E. coli
	HSP40/DNAJB1 protein, a key player in cellular processes, interacts with HSP70 to enhance ATPase activity and stimulate HSC70-HIP association. It negatively regulates HSF1 transcriptional activity in heat shock response recovery, and interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity. These multifaceted interactions showcase HSP40/DNAJB1's intricate regulatory functions in stress responses and protein folding. HSP40/DNAJB1 Protein, Human (His) is the recombinant human-derived HSP40/DNAJB1 protein, expressed by E. coli , with C-6*His labeled tag.

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Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (1) IF-Tissue (1) IP (1) WB (5) FC (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85703

	Hsp40 Antibody (YA5395) DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; Heat shock 40 kDa protein 1; Hsp40; Heat shock protein 40; Human DnaJ protein 1; hDj-1;	IHC-P, WB	Human, Mouse, Rat
	Hsp40 Antibody (YA5395) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp40.

HY-P80710

	Hsp40 Antibody (YA731) DNAJB1; DNAJ1; HDJ1; HspF1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; Heat shock 40 kDa protein 1; Hsp40; Heat shock protein 40; Human DnaJ protein 1; hDj-1	WB	Human
	Hsp40 Antibody (YA731) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp40.

HY-P80710A

	Hsp40 Antibody (YA731)(PBS only) DNAJB1; DNAJ1; HDJ1; HspF1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; Heat shock 40 kDa protein 1; Hsp40; Heat shock protein 40; Human DnaJ protein 1; hDj-1	WB	Human
	Hsp40 Antibody (YA731) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp40.

HY-P810432

	DNAJA4 Antibody (YA9743) DnaJ (Hsp40) homolog subfamily A member 4, DNAJ A4, MST104, PRO1472	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	DNAJA4 Antibody (YA9743) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to DNAJA4.

HY-P810431

	DNAJA1 Antibody (YA9743) DJ 2, DJ2, DjA1, DnaJ (Hsp40) homolog, subfamily A, member 1, DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, DNAJ2, Dnaja1, DNJA1_HUMAN, hDJ 2	WB, IHC-P, IF-Tissue, IP	Human, Mouse, Rat
	DNAJA1 Antibody (YA9743) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to DNAJA1.

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Cat. No.	Product Name		Classification

HY-RS03861

DNAJB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DNAJB1 Human Pre-designed siRNA Set A contains three designed siRNAs for DNAJB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03862

Dnajb1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dnajb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnajb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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