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IBA 12

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-182799
    IBA-12

    		PROTACs Molecular Glues IKZF Family Cancer
    IBA-12 is a IKZF2 molecular glue/PROTAC degrader with a DC50 of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC50 of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with IKZF2. IBA-12 induces IKZF2 degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading IKZF2. IBA-12 is applicable to cancer immunology research .
    IBA-12
  • HY-182807
    CRBN ligand-899

    		Others
    CRBN ligand-899 is a CRBN ligand that can be used for the synthesis of PROTACs, such as IBA-12 (HY-182799) .
    CRBN ligand-899
  • HY-182808
    E3 Ligase Ligand-linker Conjugate 230

    		E3 Ligase Ligand-Linker Conjugates Others
    E3 Ligase Ligand-linker Conjugate 230 is an E3 ligase ligand-linker conjugate that can be used for the synthesis of PROTACs, such as IBA-12 (HY-182799) .
    E3 Ligase Ligand-linker Conjugate 230

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