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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
IL-1R
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "IL-1R" in MCE Product Catalog:
56
56 Publications Verification
Synonyms: Kineret; Anakinra
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7
Emavusertib is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib exhibits antitumor activity in mouse model
6
6 Cited Publications
Cat. No.: HY-P1110
CAS No.: 185413-30-3
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Synonyms: Arcalyst; IL 1 Trap; Interleukin 1 Trap
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Cat. No.: HY-P99379
CAS No.: 2171061-85-9
Synonyms: CAN04; Anti-IL-1RAP/IL-1R3 Reference Antibody (nidanILimab)
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Cat. No.: HY-P10474
CAS No.: 1200829-06-6
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Cat. No.: HY-P990321
Synonyms: MEDI 8968
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Cat. No.: HY-P99140
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Cat. No.: HY-175022
CAS No.: 2432992-21-5
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PROTAC IRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader with DC50s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod (HY-B0180) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research [1]. Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker
Cat. No.: HY-E70731
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The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 aa104-460 Recombinant Human Active Protein Kinase is a recombinant IRAK4 aa104-460 protein that can be used to study IRAK4 aa104-460-related functions [1].
Cat. No.: HY-RS06720
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IL1R1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL1R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-171657
CAS No.: 411233-11-9
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4'-Acetoxy resveratrol is a Resveratrol (HY-16561) derivative. 4'-Acetoxy resveratrol upregulates gene expression of elastin, collagen types III and IV, superoxide dismutase (SOD), and catalase (CAT), while downregulating interleukins (IL-1A, IL-1R2, IL-6, IL-8) and cyclooxygenase-2 (COX-2) in human skin models. 4'-Acetoxy resveratrol can be used for skin reasearch [1] .
Cat. No.: HY-113893
CAS No.: 106021-96-9
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Cat. No.: HY-RS06721
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IL1R2 Human Pre-designed siRNA Set A contains three designed siRNAs for IL1R2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20038
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Il1r1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il1r1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26189
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Il1r2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il1r2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-135317B
CAS No.: 2376399-42-5
Synonyms: CA-4948 hydrochloride
Emavusertib hydrochloride (CA-4948 tosylate) is the hydrochloride salt form of Emavusertib (HY-135317). Emavusertib hydrochloride is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib hydrochloride inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib hydrochloride exhibits antitumor activity in mouse model [1] .
Cat. No.: HY-P76995
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-1 receptor type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
