16 Results for "

Isocoumarin

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "Isocoumarin" in MCE Product Catalog:

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1 Cited Publications
Cat. No.: HY-W510159
CAS No.: 56005-10-8
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .
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1 Cited Publications
Cat. No.: HY-N3300
CAS No.: 480-33-1
Synonyms: (R)-Mellein
Mellein ((R)-Mellein) is an isocoumarin compound with antibacterial activity. Mellein inhibits the activity of HCV Protease, disrupts the cell wall of Xanthomonas sp., and acts as an insect trail pheromone. Mellein is applicable to research related to fungal infections, bacterial infections, and hepatitis C virus infections .
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1 Cited Publications
Cat. No.: HY-N9447
CAS No.: 79595-97-4
Norbergenin is a polyphenolic isocoumarin derivative. Norbergenin acts as a non-competitive inhibitor of bovine adrenal tyrosine hydroxylase (TH) with a Ki value of 69.6 μM. Norbergenin inhibits lipopolysaccharide-induced inflammatory responses in macrophages by suppressing the activation of NF-κB, MAPK and STAT3, as well as blocking metabolic reprogramming . Norbergenin inhibits aluminum chloride-induced oxidative stress and apoptosis and restores neurocognitive parameters. Norbergenin scavenges ROS through multiple mechanisms and protects cell membranes from lipid peroxidation damage. Norbergenin can be used in research related to Alzheimer's disease, peptic ulcer and arthritis .
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Cat. No.: HY-N6294
CAS No.: 30270-60-1
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
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Cat. No.: HY-W751002
CAS No.: 118063-79-9
Synonyms: (+)-Orthosporin
Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of HIV-1 reverse transcriptase activity .
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Cat. No.: HY-117783
CAS No.: 126262-07-5
Target:  

Antibiotic

Research Areas:  

Infection

Y-05460M-A is a substituted isocoumarin antibiotic. Y-05460M-A exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Y-05460M-A is cytotoxic against P388 lymphatic leukemia. Y-05460M-A also has antiulcer activity. Y-05460M-A is a one-carbon lower homologue of PM-04128. Y-05460M-A can be achieved from N-Boc-L-valine .
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Cat. No.: HY-13705
CAS No.: 181427-78-1
NM-3 is an isocoumarin with antiarthritic and antiangiogenic effects. NM-3 is an orally active antiangiogenic agent with low toxicity .
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Cat. No.: HY-N2831
CAS No.: 126223-29-8
Agrimonolide 6-O-β-D-glucoside is a isocoumarin that can be isolated from Agrimonia pilosa. Agrimonolide 6-O-β-D-glucoside is used in hepatic disease research .
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Cat. No.: HY-N13291
CAS No.: 24350-93-4
Target:  

Fungal

6-O-Methylreticulol (compound 1a) is an isocoumarin isolated from an endophytic fungus on the mangrove plant Avicennia marina in the Pearl River Estuary in southern China .
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Cat. No.: HY-147950
CAS No.: 2413564-66-4
PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro .
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Cat. No.: HY-N10702
PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM .
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Cat. No.: HY-115913
Research Areas:  

Inflammation/Immunology

PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC50s of 0.125 and 0.43 µM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects .
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Cat. No.: HY-N16371
CAS No.: 39051-96-2
6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid (Compound MC-1), an isocoumarin, is a metabolite of Cytogenin (HY-19606). 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid has anti-angiogenic activity in S-180 implanted dorsal air sac mice model. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid also modifies collagen-induced arthritis. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid can be used for cancers and inflammatory diseases research .
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Cat. No.: HY-N19641
CAS No.: 244182-09-0
Synonyms: Dichlorodiaportin
Dichlorodiaporthin (Dichlorodiaportin) is an isocoumarin metabolite found in cultures of Penicillium nalgiovense. Dichlorodiaporthin acts as an antibacterial agent against various bacterial species .
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Cat. No.: HY-N19101
CAS No.: 100560-66-5
Polygonolide is an orally active isocoumarin anti-inflammatory agent. Polygonolide is present in the roots of Polygonum hydropiper and Persicaria hydropiper. Polygonolide inhibits the reversed passive Arthus reaction in rats. Polygonolide can be used in studies related to immune complex-induced inflammation .
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Cat. No.: HY-N19147
CAS No.: 2090467-41-5
Target:  

Fungal

6-Hydroxy-8-methoxy-3-methylisocoumarin is an isocoumarin that can be found in rice fermentation of sponge-derived fungus Curvularia sp. ZYX-Z-4. 6-Hydroxy-8-methoxy-3-methylisocoumarin exhibits no significant anti-inflammatory or antifungal activity .
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