16 Results for "

Isocoumarin

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "Isocoumarin" in MCE Product Catalog:

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1 Cited Publications
Cat. No.: HY-W510159
CAS No.: 56005-10-8
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .
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1 Cited Publications
Cat. No.: HY-N2830
CAS No.: 21499-24-1
Agrimonolide is a phenethyl isocoumarin compound discovered from Agrimonia pilosa, exhibiting anti-inflammatory, antioxidant, and anticancer activities. Agrimonolide inhibits NF-κB, MAPK, and TLR4-mediated neuroinflammatory signaling, suppresses Notch and JAK2/STAT3 signaling to modulate Th17/Treg balance and maintain the intestinal barrier. Agrimonolide decreases HIF1A expression, inhibits glycolysis, and induces ferroptosis and cell cycle arrest via the mTOR pathway in tumor models, thereby suppressing cancer cell viability, proliferation, and metastasis. Agrimonolide exerts hepatoprotective and anti-fibrotic effects by regulating bile acid transporter expression and reducing hepatic bile acid accumulation. Agrimonolide is used for research on ulcerative colitis, ovarian cancer, non-small cell lung cancer, cholestatic liver injury, and neuroinflammation .
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1 Cited Publications
Cat. No.: HY-N3300
CAS No.: 480-33-1
Synonyms: (R)-Mellein
Mellein ((R)-Mellein) is an isocoumarin compound with antibacterial activity. Mellein inhibits the activity of HCV Protease, disrupts the cell wall of Xanthomonas sp., and acts as an insect trail pheromone. Mellein is applicable to research related to fungal infections, bacterial infections, and hepatitis C virus infections .
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1 Cited Publications
Cat. No.: HY-N9447
CAS No.: 79595-97-4
Norbergenin is a polyphenolic isocoumarin derivative. Norbergenin acts as a non-competitive inhibitor of bovine adrenal tyrosine hydroxylase (TH) with a Ki value of 69.6 μM. Norbergenin inhibits lipopolysaccharide-induced inflammatory responses in macrophages by suppressing the activation of NF-κB, MAPK and STAT3, as well as blocking metabolic reprogramming . Norbergenin inhibits aluminum chloride-induced oxidative stress and apoptosis and restores neurocognitive parameters. Norbergenin scavenges ROS through multiple mechanisms and protects cell membranes from lipid peroxidation damage. Norbergenin can be used in research related to Alzheimer's disease, peptic ulcer and arthritis .
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Cat. No.: HY-N6294
CAS No.: 30270-60-1
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
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Cat. No.: HY-W751002
CAS No.: 118063-79-9
Synonyms: (+)-Orthosporin
Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of HIV-1 reverse transcriptase activity .
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Cat. No.: HY-117783
CAS No.: 126262-07-5
Target:  

Antibiotic

Domaines de recherche:  

Infection

Y-05460M-A is a substituted isocoumarin antibiotic. Y-05460M-A exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Y-05460M-A is cytotoxic against P388 lymphatic leukemia. Y-05460M-A also has antiulcer activity. Y-05460M-A is a one-carbon lower homologue of PM-04128. Y-05460M-A can be achieved from N-Boc-L-valine .
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Cat. No.: HY-13705
CAS No.: 181427-78-1
Target:  

Apoptosis MDM-2/p53

Domaines de recherche:  

Cardiovascular Disease Inflammation/Immunology

NM-3 is an isocoumarin with antiarthritic and antiangiogenic effects. NM-3 is an orally active antiangiogenic agent with low toxicity .
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Cat. No.: HY-N13291
CAS No.: 24350-93-4
6-O-Methylreticulol (compound 1a) is an isocoumarin isolated from an endophytic fungus on the mangrove plant Avicennia marina in the Pearl River Estuary in southern China .
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Cat. No.: HY-N2831
CAS No.: 126223-29-8
Agrimonolide 6-O-β-D-glucoside is a isocoumarin that can be isolated from Agrimonia pilosa. Agrimonolide 6-O-β-D-glucoside is used in hepatic disease research .
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Cat. No.: HY-N10702
PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM .
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Cat. No.: HY-N16371
CAS No.: 39051-96-2
6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid (Compound MC-1), an isocoumarin, is a metabolite of Cytogenin (HY-19606). 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid has anti-angiogenic activity in S-180 implanted dorsal air sac mice model. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid also modifies collagen-induced arthritis. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid can be used for cancers and inflammatory diseases research .
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Cat. No.: HY-N19641
CAS No.: 244182-09-0
Synonyms: Dichlorodiaportin
Dichlorodiaporthin (Dichlorodiaportin) is an isocoumarin metabolite found in cultures of Penicillium nalgiovense. Dichlorodiaporthin acts as an antibacterial agent against various bacterial species .
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Cat. No.: HY-N19101
CAS No.: 100560-66-5
Polygonolide is an orally active isocoumarin anti-inflammatory agent. Polygonolide is present in the roots of Polygonum hydropiper and Persicaria hydropiper. Polygonolide inhibits the reversed passive Arthus reaction in rats. Polygonolide can be used in studies related to immune complex-induced inflammation .
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Cat. No.: HY-165283
CAS No.: 1027308-36-6
Domaines de recherche:  

Cancer

Microtubule-IN-10 (compound 9) is an isocoumarin-type microtubule assembly inhibitor. Microtubule-IN-10 exerts an anti-tumor effect by inducing mitotic arrest and apoptosis in multiple myeloma cells. Microtubule-IN-10 can be used for the research of multiple myeloma .
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Cat. No.: HY-N19147
CAS No.: 2090467-41-5
6-Hydroxy-8-methoxy-3-methylisocoumarin is an isocoumarin that can be found in rice fermentation of sponge-derived fungus Curvularia sp. ZYX-Z-4. 6-Hydroxy-8-methoxy-3-methylisocoumarin exhibits no significant anti-inflammatory or antifungal activity .
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