Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
LO-2
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "LO-2" in MCE Product Catalog:
Cat. No.: HY-N10426
CAS No.: 72691-72-6
Category:
Target:
Cat. No.: HY-175033
Research Areas:
BRD4-IN-11 is an orally active and selective BRD4 inhibitor (IC50 = 26.35 nM (BD1), IC50 = 72.81 nM (BD2)). BRD4-IN-11 is approximately 3- to 18-fold more potent against BRD4 than againstBRD2, BRD3, and BRDT. BRD4-IN-11 enhances H2S release and inhibits the upregulation of fibrotic markers (α-SMA and fibronectin), c-Myc, and CDC25B. BRD4-IN-11 reduces apoptosis in LO2 hepatocytes. BRD4-IN-11 significantly improves liver and lung function in a hepatopulmonary fibrosis model and can be used to study hepatopulmonary fibrosis .
Cat. No.: HY-162564
CAS No.: 3034402-33-7
Antibacterial agent 221 (compound 3k) is a potent inhibitor of Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 221 shows significant cytotoxicity against human LO2 and HepG2 cells .
Cat. No.: HY-N7161
CAS No.: 466663-11-6
Category:
Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Plants Euphorbiaceae Extract
Target:
Cat. No.: HY-146715
CAS No.: 2409479-24-7
Target:
Research Areas:
IDO/Tubulin-IN-2 (HT2) is a potent TDO and tubulin inhibitor. IDO/Tubulin-IN-2 also shows potent activity against U87, HepG2, A549, HCT-116, and LO2 cancer cell lines, with IC50 values of 0.43, 0.036, 0.041, 0.095 and 1.04 μM, respectively. IDO/Tubulin-IN-2 remarkably promotes the antitumor activity .
Cat. No.: HY-170606
CAS No.: 3068686-30-3
Target:
Research Areas:
α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-Glucosidase inhibitor with an IC50 of 2.11 μM, which is more potent than existing α-Glucosidase inhibitors such as Acarbose (HY-B0089) (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). α-Glucosidase-IN-79 is non-cytotoxic to human normal hepatocyte (LO2) cells and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research into type 2 diabetes .
Cat. No.: HY-187711
Target:
Research Areas:
FAK-IN-33 is a potent focal adhesion kinase (FAK) inhibitor with an IC50 value of 10.23 nM against FAK. FAK-IN-33 inhibits the viability of U118-MG glioblastoma cells with an IC50 of 0.29 μM, and shows low cytotoxicity toward LO2 and 2BS cells. FAK-IN-33 can be used in studies related to glioblastoma .
Cat. No.: HY-P89640
Synonyms: Polyunsaturated fatty acid lipoxygenase ALOX15B, 15-lipoxygenase 2, Arachidonate 15-lipoxygenase B, Arachidonate 15-lipoxygenase type II, Linoleate 13-lipoxygenase 15-LOb, 15-LOX-2, 15-LOX-B, ALOX15B
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
