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Lin28a

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Methyltransferase (1) DNA/RNA Synthesis (1) MicroRNA (5) Molecular Glues (1) mRNA (1) Reference Standards (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (7) Neurological Disease (1)
Oligonucleotides:	Transcription Factors (1) mRNA (1) Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112659

Lin28-let-7 antagonist 1	MicroRNA	Neurological Disease Cancer
Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC₅₀ of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells .

HY-168437

LIN28-IN-2	MicroRNA	Cancer
LIN28-IN-2 is a *Lin28* inhibitor with activity against *Lin28a, Lin28b, and their zinc knuckle domain. LIN28-IN-2* blocks Lin28-RNA substrate binding, perturbs zinc knuckle domain conformation. LIN28-IN-2 inhibits cancer cell proliferation, spheroid growth, and induces G2/M phase arrest. LIN28-IN-2 suppresses cancer stem cell phenotypes, Lin28-mediated stress granule formation, let-7 target genes, cancer stem cell biomarkers, and neuroendocrine biomarkers expression in cancer cells. LIN28-IN-2 can be used for the research of cancer .

HY-RS07671

LIN28A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LIN28A Human Pre-designed siRNA Set A contains three designed siRNAs for LIN28A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIN28A Human Pre-designed siRNA Set A LIN28A Human Pre-designed siRNA Set A

HY-174590

*Human LIN28A* mRNA**	mRNA	Cancer
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.

HY-100692

Lin28-let-7a antagonist 1 2 Publications Verification	MicroRNA	Cancer
Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC₅₀ of 4.03 μM for Lin28A-let-7a-1 interaction.

HY-177782

SB1349	Molecular Glues MicroRNA	Cancer
SB1349 is a molecular glucose degrading agent that targets the *Lin28* protein. SB1349 can effectively induce proteasome dependent degradation of Lin28A and Lin28B. SB1349 can increase the level of mature let-7 miRNA, downregulate the oncogenes targeted by let-7, and effectively induce the differentiation of neuroblastoma cells. SB1349 can be used for cancer research .

HY-168346

TS-002455	DNA Methyltransferase DNA/RNA Synthesis	Cancer
TS-002455 (Example 668) is an inhibitor for Lin28a-dep Z11 with an IC₅₀ < 1 μM. TS-002455 is the enantiomer of TS-002266 (HY-169091) .

HY-100692R

Lin28-let-7a antagonist 1 (Standard)	MicroRNA Reference Standards	Cancer
Lin28-let-7a antagonist 1 (Standard) is the analytical standard of Lin28-let-7a antagonist 1 (HY-100692). This product is intended for research and analytical applications. Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704522

	LIN28A Protein, Human (His, SUMO) Protein Lin-28 homolog A; Lin28a; Zinc finger CCHC domain-containing protein 1; CSDD1; Lin28; ZCCHC1	Human	E. coli
	LIN28A Protein, Human (His, SUMO) is the recombinant human-derived LIN28A protein, expressed by E. coli, with N-6*His & N-SUMO tag.

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Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (6) Mouse (4)
Application:	IHC-P (3) ICC/IF (3) IF-Tissue (1) IP (2) IHC-F (1) WB (6) FC (2)
Isotype:	IgG (2) IgG2a (2) IgG2b (1)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80210

	LIN28A Antibody (YA710)	WB, ICC/IF, IHC-P	Human, Mouse
	LIN28A Antibody (YA710) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LIN28A.

HY-P85258

	LIN28A Antibody (YA4950) Lin28a; CSDD1; Lin28; ZCCHC1; Protein Lin-28 homolog A; Lin-28a; Zinc finger CCHC domain-containing protein 1	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP, FC	Human
	LIN28A Antibody (YA4950) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to LIN28A.

HY-P81728

	LIN28A Antibody (YA1473) Protein Lin-28 homolog A; Lin28a; CSDD1; Lin28; ZCCHC1	WB, IHC-P, ICC/IF, IP, FC	Human
	LIN28A Antibody (YA1473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIN28A.

HY-P85574

	LIN28A Antibody (YA5266) CSDD1; FLJ12457; Lin 28; Lin-28a; Lin28; Lin28a; LN28a_HUMAN; Protein Lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.	WB	Human, Mouse
	LIN28A Antibody (YA5266) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LIN28A.

HY-P80744

	LIN28A Antibody (YA711) CSDD1; FLJ12457; Lin 28; Lin-28a; Lin28; Lin28a; LN28a_HUMAN; Protein Lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.	WB	Human, Mouse
	LIN28A Antibody (YA711) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LIN28A.

HY-P80744A

	LIN28A Antibody (YA711)(PBS only) CSDD1; FLJ12457; Lin 28; Lin-28a; Lin28; Lin28a; LN28a_HUMAN; Protein Lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.	WB	Human, Mouse
	LIN28A Antibody (YA711) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LIN28A.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS07671

LIN28A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LIN28A Human Pre-designed siRNA Set A contains three designed siRNAs for LIN28A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174590

*Human LIN28A* mRNA**		mRNA Transcription Factors
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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