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Results for "

Locomotion

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Cholinesterase (ChE) (1) Dopamine Receptor (4) Dopamine Transporter (5) Drug Derivative (1) Endogenous Metabolite (1) FAAH (1) GSK-3 (2) iGluR (1) MAGL (1) Neuropeptide Y Receptor (1) PROTACs (1) Reference Standards (2) Sigma Receptor (1) α-synuclein (1)
By Research Areas:	Cancer (2) Metabolic Disease (1) Neurological Disease (23)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0717

Tocofersolan Maximum Cited Publications 6 Publications Verification TPGS; D-α-Tocopherol polyethylene glycol 1000 succinate; Vitamin E-TPGS	Drug Derivative	Neurological Disease Metabolic Disease
Tocofersolan is synthetic polyethylene glycol derivative of α-tocopherol. Tocofersolan is an orally active and water-soluble analog of vitamin E. Tocofersolan can reduce neurobehavioral deficits in zebrafish embryos exposed to moderate and high concentrations of BaP during early development. Tocofersolan shows antioxidant activity. Tocofersolan can be used to provide an orally bioavailable source of vitamin E .

HY-16688

RU 24969 1 Publications Verification	5-HT Receptor	Neurological Disease
RU 24969 is a preferential 5-HT_1B agonist, with a K_i of 0.38 nM, but also displays appreciable affinity for the 5-HT_1A receptor (K_i=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion .

HY-107531

A 1070722	GSK-3	Neurological Disease Cancer
A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a K_i of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion .

HY-12242

GBR 12935 dihydrochloride 1 Publications Verification	Dopamine Transporter	Neurological Disease
GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor, with the binding constant (K_d) of 1.08 nM in COS-7 cells. GBR 12935 dihydrochloride stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 dihydrochloride also prevents the d-Fenfluramine-induced head-twitch response in mice .

HY-B1017

Molindone hydrochloride EN-1733A	Dopamine Receptor	Neurological Disease
Molindone hydrochloride (EN-1733A) is an orally active and brain-penetrant dopamine D2/D5 receptor antagonist. Molindone hydrochloride shows antipsychotic and antidepressant-like activities. Molindone hydrochloride suppresses spontaneous locomotion, and antagonizes apomorphine-induced emesis. Molindone hydrochloride can be used for the research of neurological disease .

HY-P1437

Neuropeptide S (mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (mouse) is a bioactive peptide. Neuropeptide S (mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

HY-16688A

RU 24969 succinate 1 Publications Verification	5-HT Receptor	Neurological Disease
RU 24969 succinate is a 5-HT receptor agonist with K_i values of 0.38 and 2.5 nM for 5-HT_1B and 5-HT_1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease .

HY-143264

FAAH/MAGL-IN-2	FAAH MAGL	Neurological Disease
FAAH/MAGL-IN-2 is a potent, reversible, orally active, and cross the blood-brain barrier FAAH and MAGL inhibitor with IC₅₀s of 11 nM and 36 nM (K_is of 28 nM and 60 nM), respectively . FAAH/MAGL-IN-2 has the potential to research neuropathic pain without causing locomotion impairment .

HY-12242A

GBR 12935	Dopamine Transporter	Neurological Disease
GBR 12935 is a potent, and selective dopamine reuptake inhibitor, with the binding constant (K_d) of 1.08 nM in COS-7 cells. GBR 12935 stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 also prevents the d-Fenfluramine-induced head-twitch response in mice .

HY-16688B

RU 24969 hemisuccinate	5-HT Receptor	Neurological Disease
RU 24969 hemisuccinate is a preferential 5-HT_1B agonist, with a K_i of 0.38 nM, but also displays appreciable affinity for the 5-HT_1A receptor (K_i=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion .

HY-16688R

RU 24969 (Standard)	5-HT Receptor	Neurological Disease
RU 24969 (Standard) is the analytical standard of RU 24969. This product is intended for research and analytical applications. RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion .

HY-10847A

SB-277011 dihydrochloride SB-277011A dihydrochloride	Dopamine Receptor	Neurological Disease
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor antagonist, with pK_is of 8.0, 6.0, <5.2 and 5.9 for D₃, D₂, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-N12622

AChE-IN-58	Cholinesterase (ChE)	Neurological Disease
AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ₁-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms .

HY-12242B

GBR 12935 fumarate	Dopamine Transporter	Neurological Disease
GBR 12935 fumarate is a potent, and selective dopamine reuptake inhibitor, with the binding constant (K_d) of 1.08 nM in COS-7 cells. GBR 12935 fumarate stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 fumarate also prevents the d-Fenfluramine-induced head-twitch response in mice .

HY-B1017R

Molindone hydrochloride (Standard) EN-1733A (Standard)	Reference Standards Dopamine Receptor	Neurological Disease
Molindone hydrochloride (Standard) is the analytical standard of Molindone hydrochloride (HY-B1017). This product is intended for research and analytical applications. Molindone hydrochloride (EN-1733A) is an orally active and brain-penetrant dopamine D2/D5 receptor antagonist. Molindone hydrochloride shows antipsychotic and antidepressant-like activities. Molindone hydrochloride suppresses spontaneous locomotion, and antagonizes apomorphine-induced emesis. Molindone hydrochloride can be used for the research of neurological disease .

HY-12242R

GBR 12935 dihydrochloride (Standard)	Dopamine Transporter	Neurological Disease
GBR 12935 (dihydrochloride) (Standard) is the analytical standard of GBR 12935 (dihydrochloride). This product is intended for research and analytical applications. GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 dihydrochloride stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 dihydrochloride also prevents the d-Fenfluramine-induced head-twitch response in mice .

HY-107531R

A 1070722 (Standard)	Reference Standards GSK-3	Neurological Disease Cancer
A 1070722 (Standard) is the analytical standard of A 1070722 (HY-107531). This product is intended for research and analytical applications. A 1070722 is a potent and selective glycogen synthase K_inase 3 (GSK-3) inhibitor, with a K_i of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion .

HY-W742645

7α-Hydroxypregnenolone	Endogenous Metabolite	Others
7α-Hydroxypregnenolone, a bioactive neurosteroid, is a key neuronal modulator of locomotion. 7α-Hydroxypregnenolone stimulates upstream migration by means of the dopaminergic system in salmon .

HY-181649

S1R agonist 3	Sigma Receptor	Neurological Disease
S1R agonist 3 is a potent, selective and brain-penetrant sigma-1 receptor (S1R) agonist with a K_i of 1.5 nM. S1R agonist 3 reduces hyperlocomotion in wfs1abKO zebrafish larvae without affecting locomotion in wildtype wfs1abWT zebrafish larvae. S1R agonist 3 reverses Aβ_25-35 (HY-P0128)-induced learning and memory impairments. S1R ligand 1 can be used for the research of Alzheimer’s disease .

HY-183324

AMPA receptor modulator-12	iGluR Dopamine Transporter	Neurological Disease
AMPA receptor modulator-12 is an orally acrive AMPA receptor positive allosteric modulator. AMPA receptor modulator-12 also exhibits moderate binding affinity for the human dopamine transporter with a K_d of 1.57 μM. AMPA receptor modulator-12 enhances AMPA receptor-mediated ion currents, delays channel deactivation. AMPA receptor modulator-12 prolongs sleep latency, reduces sleep duration, extends forced swimming time, improves rotarod endurance, and alleviates acute sleep deprivation-related behavioral deficits. AMPA receptor modulator-12 does not increase spontaneous locomotion. AMPA receptor modulator-12 can be used for the research of narcolepsy and fatigue-related conditions .

HY-180976

Arg-PEG1-Tαsyn	PROTACs α-synuclein	Neurological Disease
Arg-PEG1-Tαsyn is an α-syn PROTAC degrader with a DC₅₀ of 0.28 μM in U251 cells. Arg-PEG1-Tαsyn employs the amino acid arginine (Arg) as the E3 ligase UBR1 ligand and a benzothiazole-aniline variant as the warhead for α-syn. Arg-PEG1-Tαsyn significantly reduces α-syn aggregates and improves the dopaminergic neuronal impairment and the locomotion with safety profile in vivo.Arg-PEG1-Tαsyn shows the high degradation effect in mammalian cells for both wild-type α-syn and the α-syn (A53T) mutant. Arg-PEG1-Tαsyn can be used for Parkinson’s disease research .

HY-182381

FLA-797	Dopamine Receptor	Neurological Disease
FLA-797 is a brain-penetrant dopamine D2 receptor blocker and very low affinity for dopamine D1 receptors. FLA-797 selectively binds to and blocks postsynaptic dopamine D2 receptors. FLA-797 induces catalepsy in male rats. FLA-797 blocks dopamine agonist-induced hypothermia in male rats. FLA-797 contributes marginally to the dopamine D2 receptor-blocking activity of Remoxipride (HY-101313) in male rats. FLA-797 does not mimic the atypical antipsychotic profile of Remoxipride. FLA-797 can be used for research on mental disorders .

Neuropeptide S (mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (mouse) is a bioactive peptide. Neuropeptide S (mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

NocII	Peptides	Neurological Disease
NocII is an orphan neuropeptide which stimulates locomotion in mice .

NocII TFA	Peptides	Neurological Disease
NocII TFA is an orphan neuropeptide which stimulates locomotion in mice .

AChE-IN-58	Flavonoids Flavones Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Cholinesterase (ChE)
AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ₁-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms .

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Locomotion

Inhibitors & Agonists

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