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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
MetAP1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "MetAP1" in MCE Product Catalog:
Target:
Research Areas:
M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM) [1]. M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .
Cat. No.: HY-W011539
CAS No.: 24683-26-9
EcMetAP1-IN-1 (compound 4) is an inhibitor of Escherichia coli methionine aminopeptidase MetAP1 [1].
Cat. No.: HY-118953
CAS No.: 270902-51-7
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LAF389, a prodrug of LAF153 (HY-183876), is a methionine aminopeptidase (MetAps) inhibitor with an IC50 of 800 nM against MetAp2, and exhibits a maximum inhibition rate of 20% against MetAp1 at 300 nM. LAF389 possesses antiproliferative, antiangiogenic and cytotoxic activities. LAF389 can be used in research related to cancers such as advanced solid tumors [1] .
Cat. No.: HY-RS08348
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Research Areas:
METAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17313
Target:
Research Areas:
Metap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Metap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23768
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Research Areas:
Metap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Metap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-116861
CAS No.: 369358-07-6
A-357300 is a reversible and selective MetAP2 inhibitor with IC50s of 0.12 and 57 μM against MetAP2 and MetAP1. A-357300 induces cytostasis by cell cycle arrest at the G1 phase selectively in endothelial cells and in a subset of tumor cells. A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. A-357300 can be used for the studies of neuroblastoma, fibrosarcoma and breast cancer [1].
Cat. No.: HY-W282615
CAS No.: 341944-06-7
Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection [1].
Cat. No.: HY-RS08349
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Research Areas:
METAP1D Human Pre-designed siRNA Set A contains three designed siRNAs for METAP1D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26041
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Metap1d Rat Pre-designed siRNA Set A contains three designed siRNAs for Metap1d gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184777
CAS No.: 94367-34-7
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Research Areas:
Met-AMC is a fluorescent substrate used to detect the activity of methionine aminopeptidase (MetAP). Hydrolysis of the substrate releases the fluorophore AMC, with detection performed at an excitation wavelength of 360 nm and an emission wavelength of 460 nm. Met-AMC can distinguish the effects of different metal cofactors on the substrate preference of MetAP1: Zn (II)-MetAP1 barely hydrolyzes Met-AMC, while Co (II)-, Mn (II)-, and Ni (II)-MetAP1 can stably cleave this substrate. Met-AMC can be used to establish an intracellular MetAP activity cell-based assay system, which quantifies the intracellular MetAP inhibition level by monitoring the fluorescence signal from substrate hydrolysis in living cells [1] .
Cat. No.: HY-122225
CAS No.: 836671-12-6
JNJ-4929821 (Compound 88), a triazole derivative, is a selective Methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 15 nM over MetAP-1. JNJ-4929821 can be used for cancers like liver cancer, colorectal adenocarcinoma and pancreatic cancer research [1].
Cat. No.: HY-RS19545
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Research Areas:
Metap1d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Metap1d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P70862
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MetAP1D; Peptidase M 1D; Methionyl Aminopeptidase Type 1D, Mitochondrial; MetAP 1D; MAP1D; MAP 1D; MetAP1l; CDS Of MetAP-3 Within PCR Fragment; Methionine Aminopeptidase 1D, Mitochondrial; Methionine Aminopeptidase 1D
Species:
Human
Source:
E. coli
Cat. No.: HY-P705528
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MetAP1D; Peptidase M 1D; Methionyl Aminopeptidase Type 1D, Mitochondrial; MetAP 1D; MAP1D; MAP 1D; MetAP1l; CDS Of MetAP-3 Within PCR Fragment; Methionine Aminopeptidase 1D, Mitochondrial; Methionine Aminopeptidase 1D
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
