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Results for "

NMT

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

2

Peptides

1

Natural
Products

5

Antibodies

6

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147308
    Zelenirstat
    2 Publications Verification

    PCLX-001

    		 N-myristoyltransferase Cancer
    Zelenirstat is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. Zelenirstat can induce cell apoptosis, has anti-cancer activity, inhibits early B cell receptor (BCR) signaling, and can be used to study malignant lymphoma .
    Zelenirstat
  • HY-112258
    IMP-1088
    Maximum Cited Publications
    8 Publications Verification

    		 DNA/RNA Synthesis Infection
    IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection .
    IMP-1088
  • HY-103056
    DDD85646
    1 Publications Verification

    IMP-366

    		 DNA/RNA Synthesis Parasite Infection
    DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
    DDD85646
  • HY-164285
    MYX1715

    IMP1320

    		 ADC Payload N-myristoyltransferase Cancer
    MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin .
    MYX1715
  • HY-160945
    NMT-IN-7

    		ADC Payload N-myristoyltransferase Cancer
    NMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin .
    NMT-IN-7
  • HY-126833A
    Myristoyl coenzyme A lithium
    1 Publications Verification

    		 Endogenous Metabolite Infection Cancer
    Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms .
    Myristoyl coenzyme A lithium
  • HY-P6028A
    GSNKSKPK-NH2 TFA

    		N-myristoyltransferase Others
    GSNKSKPK-NH2 TFA is a synthetic model peptide based on the c-Src N-terminal sequence and model peptide substrate for human NMT1 and NMT2.GSNKSKPK-NH2 TFA facilitates in vitro assays measuring transfer of myristate or X10 fatty acid moieties .
    GSNKSKPK-NH2 TFA
  • HY-153021
    NMT-IN-1

    		Parasite Infection
    NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC50 of 31 μM against TbNMT and an IC50 of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .
    NMT-IN-1
  • HY-RS09389
    NMT1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NMT1 Human Pre-designed siRNA Set A
    NMT1 Human Pre-designed siRNA Set A
  • HY-171814
    Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7

    		Drug-Linker Conjugates for ADC N-myristoyltransferase Cancer
    Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 (Compound DC-2) is a drug-linker conjugate for ADC. Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 consists of a NMT inhibitor (HY-160945) and a stable and cleavable linker (Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)). Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 can be used for synthesis of ADCs .
    Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7
  • HY-171788
    NMT-IN-8

    		N-myristoyltransferase Cancer
    NMT-IN-8 (Compound Ex.129) is an orally active and highly selective inhibitor of N-myristoyl transferase (NMT) with an IC50 value of ＜10 nM. NMT-IN-8 binds to the peptide binding pocket of NMT, blocking its catalyzed protein N-myristoylation to interfere with key pathways such as protein trafficking, signal transduction, and viral replication. NMT-IN-8 is promising for research of oncology (e.g., MYC-addicted cancers, B-cell lymphoma) and infectious diseases (e.g., malaria, HIV, rhinovirus infection) .
    NMT-IN-8
  • HY-126833B
    Myristoyl coenzyme A triammonium
    1 Publications Verification

    14:0 Coenzyme A triammonium; S-Tetradecanoate-CoA triammonium; S-Tetradecanoate-coenzyme A triammonium

    		 Endogenous Metabolite Infection Cancer
    Myristoyl coenzyme A triammonium (14:0 Coenzyme A) is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms .
    Myristoyl coenzyme A triammonium
  • HY-P6028
    GSNKSKPK-NH2

    		N-myristoyltransferase Others
    GSNKSKPK-NH2 is a synthetic model peptide based on the c-Src N-terminal sequence and model peptide substrate for human NMT1 and NMT2.GSNKSKPK-NH2 facilitates in vitro assays measuring transfer of myristate or X10 fatty acid moieties .
    GSNKSKPK-NH2
  • HY-158364
    NMT-IN-3

    		Parasite Infection
    NMT-IN-3 is an inhibitor of N-myristoyltransferase (NMT). The IC50 of NMT-IN-3 for Plasmodium vivax NMT is 38 mM .
    NMT-IN-3
  • HY-W721249
    5-Methoxy NMT

    5-MeO-NMT

    		 Biochemical Assay Reagents Neurological Disease
    5-Methoxy NMT is an organic compound of the tryptamine class. 5-Methoxy NMT can be metabolized in the liver by the action of cytochrome p450 enzymes .
    5-Methoxy NMT
  • HY-168652
    4-PivO-NMT chloride

    		AMPK Neurological Disease Inflammation/Immunology
    4-PivO-NMT chloride is an indole-derived AMPK signaling pathway modulator that regulates neurogenesis or neurite outgrowth by modulating AMPK activity. 4-PivO-NMT chloride holds promise for research in the fields of neurological disorders, pain, and inflammation .
    4-PivO-NMT chloride
  • HY-RS09390
    NMT2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NMT2 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NMT2 Human Pre-designed siRNA Set A
    NMT2 Human Pre-designed siRNA Set A
  • HY-RS18960
    Nmt1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nmt1 Mouse Pre-designed siRNA Set A
    Nmt1 Mouse Pre-designed siRNA Set A
  • HY-RS18145
    Nmt2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nmt2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nmt2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nmt2 Mouse Pre-designed siRNA Set A
    Nmt2 Mouse Pre-designed siRNA Set A
  • HY-RS25450
    Nmt1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nmt1 Rat Pre-designed siRNA Set A
    Nmt1 Rat Pre-designed siRNA Set A
  • HY-122134
    SC-58272

    		Fungal Infection
    SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC50 of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme .
    SC-58272
  • HY-W703869
    5-Hydroxy NMT oxalate

    N-Methylserotonin oxalate; 5-Hydroxy-N-methyl tryptamine oxalate

    		 Drug Metabolite Neurological Disease
    5-Hydroxy NMT (N-Methylserotonin) oxalate is a metabolite of 5-HT and belongs to the tryptamine class of compounds. Elevated levels of 5-Hydroxy NMT oxalate in plasma are associated with cocaine addiction .
    5-Hydroxy NMT oxalate
  • HY-132211
    3-Thiatetradecanoic acid

    		PPAR Others
    3-Thiatetradecanoic acid is a substrate of N-myristoyltransferase (NMT), which is involved in the metabolism of thiofatty acids .
    3-Thiatetradecanoic acid
  • HY-136625
    LY134046

    		N-myristoyltransferase Cardiovascular Disease
    LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.
    LY134046
  • HY-RS24620
    Nmt2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nmt2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nmt2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nmt2 Rat Pre-designed siRNA Set A
    Nmt2 Rat Pre-designed siRNA Set A
  • HY-103056R
    DDD85646 (Standard)

    IMP-366 (Standard)

    		 Reference Standards DNA/RNA Synthesis Parasite Infection
    DDD85646 (Standard) is the analytical standard of DDD85646 (HY-103056). This product is intended for research and analytical applications. DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
    DDD85646 (Standard)
  • HY-134199
    IMP-1002

    		N-myristoyltransferase Parasite Infection
    IMP-1002 is a Plasmodium N-myristoyltransferase (NMT) inhibitor. IMP-1002 inhibits myristoylation activity, blocks parasite development. IMP-1002 can be used for the research of malaria .
    IMP-1002
  • HY-183263
    MYX1715 analog 1

    		ADC Payload N-myristoyltransferase Cancer
    MYX1715 analog 1 is an analog of MYX1715 (HY-164285). MYX1715 analog 1 is an N-myristoyltransferase (NMT) inhibitor that inhibits protein myristoylation modification. MYX1715 analog 1 can be conjugated to targeting antibodies via cleavable or non-cleavable linkers for use as an ADC cytotoxin. MYX1715 analog 1 is used in the development of drugs targeting tumor-associated antigens .
    MYX1715 analog 1

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