Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
NMT
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "NMT" in MCE Product Catalog:
9
9 Publications Verification
Target:
Research Areas:
IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection .
2
Target:
Research Areas:
Zelenirstat is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. Zelenirstat can induce cell apoptosis, has anti-cancer activity, inhibits early B cell receptor (BCR) signaling, and can be used to study malignant lymphoma .
1
Target:
Research Areas:
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
1
1 Cited Publications
Target:
1
1 Cited Publications
Cat. No.: HY-126833B
CAS No.: 799812-85-4
Synonyms: 14:0 Coenzyme A triammonium; S-Tetradecanoate-CoA triammonium; S-Tetradecanoate-coenzyme A triammonium
Target:
Myristoyl coenzyme A triammonium (14:0 Coenzyme A) is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms .
Cat. No.: HY-164285
CAS No.: 2445448-66-6
Synonyms: IMP1320
Target:
Research Areas:
MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin .
Cat. No.: HY-160945
CAS No.: 3032302-70-5
Target:
Research Areas:
NMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin .
Cat. No.: HY-P6028A
Target:
Research Areas:
NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC50 of 31 μM against TbNMT and an IC50 of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .
Cat. No.: HY-RS09389
Target:
Research Areas:
NMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-171814
CAS No.: 3032302-82-9
Research Areas:
Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 (Compound DC-2) is a drug-linker conjugate for ADC. Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 consists of a NMT inhibitor (HY-160945) and a stable and cleavable linker (Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)). Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 can be used for synthesis of ADCs .
Cat. No.: HY-171788
CAS No.: 2765258-26-0
Target:
Research Areas:
NMT-IN-8 (Compound Ex.129) is an orally active and highly selective inhibitor of N-myristoyl transferase (NMT) with an IC50 value of ＜10 nM. NMT-IN-8 binds to the peptide binding pocket of NMT, blocking its catalyzed protein N-myristoylation to interfere with key pathways such as protein trafficking, signal transduction, and viral replication. NMT-IN-8 is promising for research of oncology (e.g., MYC-addicted cancers, B-cell lymphoma) and infectious diseases (e.g., malaria, HIV, rhinovirus infection) .
Cat. No.: HY-P6028
Target:
Research Areas:
Cat. No.: HY-W721249
CAS No.: 2009-03-2
Synonyms: 5-MeO-NMT
Target:
Research Areas:
5-Methoxy NMT is an organic compound of the tryptamine class. 5-Methoxy NMT can be metabolized in the liver by the action of cytochrome p450 enzymes .
Cat. No.: HY-168652
CAS No.: 3019920-38-5
Target:
Research Areas:
4-PivO-NMT chloride is an indole-derived AMPK signaling pathway modulator that regulates neurogenesis or neurite outgrowth by modulating AMPK activity. 4-PivO-NMT chloride holds promise for research in the fields of neurological disorders, pain, and inflammation .
Cat. No.: HY-RS09390
Target:
Research Areas:
NMT2 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18145
Target:
Research Areas:
Nmt2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nmt2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18960
Target:
Research Areas:
Nmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25450
Target:
Research Areas:
Nmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
