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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
NODAL
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "NODAL" in MCE Product Catalog:
143
143 Cited Publications
Target:
Research Areas:
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
2
2 Cited Publications
Cat. No.: HY-P700025AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NODAL; NODAL, Mouse, Homolog; NODAL Growth Differentiation Factor; NODAL Homolog (Mouse); NODAL Homolog; HTX5
Species:
Human
Source:
E. coli
Target:
Research Areas:
IDE 2 is a cell-permeable inducer of definitive endoderm differentiation that induces the differentiation of mouse and human embryonic stem cells into definitive endoderm. IDE2 activates the TGF‑β/Nodal signaling pathway, induces Smad2 phosphorylation, and increases Sox17 and FoxA2 expression. Endoderm induced by IDE 2 integrates into the developing gut tube, expresses gut tube markers, and differentiates into pancreatic progenitor cells. IDE 2 can be used for research related to directed endoderm differentiation of embryonic stem cells .
Cat. No.: HY-10432R
CAS No.: 909910-43-6
Target:
Research Areas:
A 83-01 (Standard) is the analytical standard of A 83-01 (HY-10432). This product is intended for research and analytical applications. A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
Cat. No.: HY-RS09409
Target:
Research Areas:
NODAL Human Pre-designed siRNA Set A contains three designed siRNAs for NODAL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19222
Target:
Research Areas:
Nodal Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nodal gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P704126
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NODAL; NODAL, Mouse, Homolog; NODAL Growth Differentiation Factor; NODAL Homolog (Mouse); NODAL Homolog; HTX5
Species:
Human
Source:
E. coli
Cat. No.: HY-123196
CAS No.: 342419-09-4
Target:
Research Areas:
CVT-2759 is a potent inhibitor of A1-ADOR, with the IC50 values of 0.18 μM and 9.5 μM to reduce the binding of [3H]CPX in the absence and presence of 1 mM GTP. CVT-2759 plays an important role in slowing AV nodal conduction and thereby ventricular rate without causing AV block, bradycardia, atrial arrhythmias, or vasodilation .
Cat. No.: HY-RS25711
Target:
Research Areas:
Nodal Rat Pre-designed siRNA Set A contains three designed siRNAs for Nodal gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11931
NODA-FGLP21 is a tumor-targeting agent and a fibrinogen-like protein 1 (FGL1) binder. NODA-FGLP21 specifically binds to FGL1, and this binding is competitively inhibited by unlabeled FGLP21. NODA-FGLP21 can be used in the research of liver cancer .
Cat. No.: HY-180334
CAS No.: 120004-07-1
Target:
Research Areas:
S-312 is a calcium antagonist with a bicyclic dihydrothienopyridine structure. S-312 can relax the helical strips of various isolated rabbit arteries procontracted with high potassium depolarizaiton. S-312 competitively imhibits calcium-induced contractions in depolarized basilar and femoral arteries. S-312 increases AV nodal conduction time in Langenedorff-perfused isolated rabbit hearts. S-312 exhibits vasculoselectivity, particularly for cerebral vessel .
Cat. No.: HY-118968
CAS No.: 112946-90-4
Target:
Research Areas:
(-)-SA2572 is an orally active Ca 2+ inward channel inhibitor. (-)-SA2572 inhibits the slow Ca 2+ inward channel and the fast Na + inward channel. (-)-SA2572 inhibits depolarization-induced contraction of gastrointestinal smooth muscle and vascular smooth muscle, prolongs atrioventricular nodal conduction time, and inhibits His bundle-ventricular conduction time. (-)-SA2572 reduces systolic blood pressure in spontaneously hypertensive rats. (-)-SA2572 can be used in the research of hypertension .
Cat. No.: HY-10321G
CAS No.: 219580-11-7
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
