16 Results for "

NPFF2

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "NPFF2" in MCE Product Catalog:

1
1 Cited Publications
Referencia número: HY-P1428
No. CAS: 311309-25-8
Áreas de investigación:  

Endocrinology

RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively [2] .
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Referencia número: HY-P1248
No. CAS: 99566-27-5
Synonyms: NPFF
Áreas de investigación:  

Cardiovascular Disease Neurological Disease

Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain [2] .
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Referencia número: HY-161405
No. CAS: 3057753-40-6
Áreas de investigación:  

Neurological Disease

NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively .
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Referencia número: HY-P10377
Áreas de investigación:  

Metabolic Disease

GUB03385 is a long-acting PrRP31 analogue. GUB03385 is a potent dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM). GUB03385 has anti-obesity effect .
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Referencia número: HY-P3843
No. CAS: 99588-52-0
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects [2].
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Referencia número: HY-161382
Áreas de investigación:  

Neurological Disease

NPFF2-R ligand 1 (Compound 16a) is a NPFF2-R ligand, with Kis of 228 and 27 nM for NPFF1-R and NPFF2-R respectively. NPFF2-R ligand 1 can be used for research related with central nervous system .
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Referencia número: HY-P1249
No. CAS: 230960-31-3
Áreas de investigación:  

Neurological Disease

Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .
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Referencia número: HY-P1249A
Áreas de investigación:  

Neurological Disease

Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .
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Referencia número: HY-P1428A
Áreas de investigación:  

Cardiovascular Disease

RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.
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Referencia número: HY-154829A
No. CAS: 849335-07-5
Pureza:  99.92%
Áreas de investigación:  

Inflammation/Immunology

AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats [2].
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Referencia número: HY-RS28417
Áreas de investigación:  

Others

Npffr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npffr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Referencia número: HY-154829
No. CAS: 849459-88-7
Áreas de investigación:  

Inflammation/Immunology

AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats [2].
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Referencia número: HY-RS21900
Áreas de investigación:  

Others

Npffr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npffr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-RS09482
Áreas de investigación:  

Others

NPFFR2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPFFR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-P11810A
Áreas de investigación:  

Metabolic Disease

GUB08248 acetate is a full GPR10 agonist and a partial NPFF2R agonist, with EC50 values of 0.5 nM and 2.5 nM, respectively. GUB08248 acetate inhibits food intake and induces sustained weight loss. GUB08248 acetate can be used in obesity-related research [2].
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Referencia número: HY-P11810
Áreas de investigación:  

Metabolic Disease

GUB08248 is a full GPR10 agonist and a partial NPFF2R agonist, with EC50 values of 0.5 nM and 2.5 nM, respectively. GUB08248 inhibits food intake and induces sustained weight loss. GUB08248 can be used in obesity-related research [2].
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