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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
PREP
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "PREP" in MCE Product Catalog:
2
2 Cited Publications
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UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM .
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1 Cited Publications
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Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research .
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1 Cited Publications
Cat. No.: HY-W404002
CAS No.: 2505339-54-6
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BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2
Cat. No.: HY-17455
CAS No.: 68497-62-1
Synonyms: CI-879 free base
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Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases .
Cat. No.: HY-D2363
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PREP inhibitor-1 (compound 27a) is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC50 < 1 nM).
Cat. No.: HY-116828
CAS No.: 1432499-51-8
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ARI-3531 (compound 22) is a selective prolyl oligopeptidase (PREP) inhibitor (Ki=0.73 nM). ARI-3531 can be used to study tumor invasion and metastasis .
Cat. No.: HY-W001273
CAS No.: 72869-16-0
Synonyms: CI-879 sulfate
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Pramiracetam (CI-879) sulfate Pramiracetam is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam sulfate improves cognitive impairment caused by traumatic brain injury. Pramiracetam sulfate can be used in the study of neurodegenerative diseases .
Cat. No.: HY-15113A
CAS No.: 143984-17-2
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Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) .
Cat. No.: HY-134454A
CAS No.: 88795-32-8
Synonyms: N-Benzyloxycarbonyl-L-prolyl-L-prolinal
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Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP .
Cat. No.: HY-178981
CAS No.: 3075119-33-1
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FAP-IN-8 (Compound 12i) is a potent inhibitor of PREP and FAP, with pIC50 values of 8.99 and 10.08 for FAP and PREP, and IC50 values of 1 and 0.08 nM, respectively. FAP-IN-8 may be used in cancer research .
Cat. No.: HY-P4308
CAS No.: 170116-63-9
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Cat. No.: HY-15112
CAS No.: 162203-65-8
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JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096) .
Cat. No.: HY-179348
CAS No.: 3020859-44-0
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DPP9-IN-2 is a selective, potent and orally active inhibitor of Dipeptidyl Peptidase 9 (DPP9 ) with an IC50 of 12.9 nM. DPP9-IN-2 shows a SI of 59 over DPP8, and shows no significant inhibitory activity against related peptidases including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce cancer cells pyroptosis and has weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitor. DPP9-IN-2 can be used for the researches of cance rand infection .
Cat. No.: HY-RS11083
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PREP Human Pre-designed siRNA Set A contains three designed siRNAs for PREP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24103
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Prep Rat Pre-designed siRNA Set A contains three designed siRNAs for Prep gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-17455R
CAS No.: 68497-62-1
Synonyms: CI-879 free base (Standard)
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Pramiracetam (Standard) is the analytical standard of Pramiracetam. This product is intended for research and analytical applications. Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases .
Cat. No.: HY-RS10580
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PITRM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PITRM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181070
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PREP-IN-2 is an irreversible and selective prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.53 μM and a Ki of 0.62 μM. PREP-IN-2 can be used in research related to neurodegenerative diseases and triple-negative breast cancer .
Cat. No.: HY-15113
CAS No.: 129184-48-1
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Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
