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Isoforms Recommended:	PRMT8

Results for "

PRMT8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) ATP-binding cassette (ABC) transporters (1) DNA/RNA Synthesis (1) Histone Methyltransferase (17) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (16)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19615

MS023 Maximum Cited Publications 22 Publications Verification	Histone Methyltransferase	Cancer
MS023, a chemical probe, is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-128717A

GSK3368715 dihydrochloride 15+ Cited Publications EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-12970A

EPZ020411 hydrochloride 5+ Cited Publications	Histone Methyltransferase Apoptosis	Cancer
EPZ020411 hydrochloride is a selective inhibitor of *PRMT6* with an IC₅₀ of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer .

HY-128717

GSK3368715 15+ Cited Publications EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-12970

EPZ020411 5+ Cited Publications	Histone Methyltransferase Apoptosis	Cancer
EPZ020411 is a selective inhibitor of *PRMT6* with an IC₅₀ of 10 nM, has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 can be used for the research of cancer .

HY-19615B

MS023 dihydrochloride Maximum Cited Publications 22 Publications Verification	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-RS11185

Prmt8 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prmt8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt8 Rat Pre-designed siRNA Set A Prmt8 Rat Pre-designed siRNA Set A

HY-RS11183

PRMT8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRMT8 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT8 Human Pre-designed siRNA Set A PRMT8 Human Pre-designed siRNA Set A

HY-RS11184

Prmt8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt8 Mouse Pre-designed siRNA Set A Prmt8 Mouse Pre-designed siRNA Set A

HY-178114

SKLB-0124	Histone Methyltransferase Apoptosis	Cancer
SKLB-0124 is a selective *PRMT6* degrader with DC₅₀s of 15.4 μM and a 16.4 μM in HCC827 and MDA-MB-435 cells. SKLB-0124 does not degrade PRMT1 or PRMT8. SKLB-0124 exhibits an IC₅₀ on PRMT6 of 1.6 μM. SKLB-0124 induces proteasome dependent degradation of PRMT6 and significantly inhibits the proliferation. SKLB-0124 effectively induces apoptosis and cell cycle arrest. SKLB-0124 can be used for the studies of lung cancer and breast cancer .

HY-175821

PRMT1-IN-3	Histone Methyltransferase Apoptosis	Cancer
PRMT1-IN-3 is a potent protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 4.11 μM. PRMT1-IN-3 inhibits *PRMT6* and *PRMT8* with IC₅₀s of 23.3 and 30.1 μM. PRMT1-IN-3 suppresses asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a modification in triple-negative breast cancer (TNBC) cells. PRMT1-IN-3 induces cell cycle arrest, apoptosis, and inhibits migration and colony formation in MDA-MB-231 cells. PRMT1-IN-3 acts as chemotherapeutic sensitizers for Paclitaxel (HY-B0015). PRMT1-IN-3 can be used for the study of TNBC .

HY-162003

DCPT1061	Histone Methyltransferase	Cancer
DCPT1061 potently inhibits PRMT1, PRMT6 and PRMT8 in vitro with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. DCPT1061 has antitumor effect .

HY-162003A

DCPT1061 hydrochloride	Histone Methyltransferase	Cancer
DCPT1061 hydrochloride has a strong inhibitory effect on *PRMT1, PRMT6, and PRMT8* in vitro, The epigenetic enzymes such as *PRMT3, PRMT4* and *PRMT5* had little inhibitory effect. DCPT1061 hydrochloride has antitumor effects .

HY-155154

PRMT4-IN-2	Histone Methyltransferase	Cancer
PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with IC₅₀s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM ( PRMT8), 1.386 μM (PRMT3) .

HY-19615A

MS023 trihydrochloride	Histone Methyltransferase	Cancer
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-128717C

GSK3368715 hydrochloride EPZ019997 hydrochloride	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) hydrochloride is an orally active, reversible, SAM-noncompetitive type I protein arginine methyltransferase (PRMT) inhibitor with IC₅₀ values of 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), and 1.7 nM (PRMT8). GSK3368715 hydrochloride induces a shift in arginine methylation states, alters exon usage, and exhibits potent anticancer activity .

HY-W013500

(1-Nitroethene-1,2-diyl)dibenzene alpha-Nitrostilbene; α-Nitrostilbene; NSC 385	Histone Methyltransferase	Others
(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀=11 μM in histone H4 methylation assay). It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at concentrations of 10 and 100 μM.

HY-128717B

GSK3368715 trihydrochloride EPZ019997 trihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-186045

SKLB06489	Histone Methyltransferase Apoptosis DNA/RNA Synthesis ATP-binding cassette (ABC) transporters	Cancer
SKLB06489 is a selective and orally active inhibitor of type I PRMT enzymes, with IC₅₀ values of 64.55 nM (PRMT1), 4.21 nM (PRMT6), and 51.27 nM (PRMT8). SKLB06489 inhibits cell proliferation, colony formation, DNA replication, and DNA damage repair in cancer cells. SKLB06489 induces G0/G1-phase cell cycle arrest and apoptosis in cancer cells. SKLB06489 enhances intracellular cholesterol efflux via ABCA1 and ABCG1 upregulation, disrupts cholesterol metabolic homeostasis, and suppresses tumor growth in subcutaneous xenograft models. SKLB06489 can be used for the research of triple-negative breast cancer (TNBC) .

HY-183653

AK442	Histone Methyltransferase	Cancer
AK442 is a selective *PRMT4* (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research .

Prmt8 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Prmt8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prmt8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRMT8 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt8 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Prmt8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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