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Results for "

PSGL-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Arenavirus (1) c-Myc (1) Chemerin Receptor (1) E-Selectin (1) ERK (1) NF-κB (1) P-selectin (6) p38 MAPK (1) Small Interfering RNA (siRNA) (3) Src (1) Syk (1) TNF Receptor (1) Transmembrane Glycoprotein (1) VISTA (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (6) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9987

Crizanlizumab 1 Publications Verification hSel001; SEG101	P-selectin	Cardiovascular Disease
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease ^[1] .

HY-P99378

Neihulizumab ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab)	Apoptosis	Inflammation/Immunology
Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research ^[1].

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of *PSGL-1* expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury ^[1] .

HY-103358

KF38789 2 Publications Verification	P-selectin	Inflammation/Immunology
KF38789 is a selective inhibitor of *P-selectin-PSGL-1* binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC₅₀ value of 1.97 μM ^[1].

HY-P990166

*Anti-Mouse PSGL-1/CD162 Antibody (4RA10)*	Apoptosis Transmembrane Glycoprotein Arenavirus	Infection Inflammation/Immunology
Anti-Mouse PSGL-1/CD162 Antibody (4RA10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse *PSGL-1/CD162. Anti-Mouse PSGL-1/CD162* Antibody (4RA10) blocks PSGL signaling and inhibits leukocyte rolling. Anti-Mouse PSGL-1/CD162 Antibody (4RA10) can be used for the researches of inflammation, immunology and infection, such as pneumonia and lymphocytic choriomeningitis virus infection ^[1] .

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion ^[1] .

HY-125475

Rivipansel GMI-1070	E-Selectin	Cardiovascular Disease
Rivipansel is a small-molecule glycomimetic pan-selectin antagonist with inhibitory activity against E-selectin and P-selectin. Rivipansel binds tightly to the lectin domain of E-selectin, and selectively blocks the recognition of CD62L by E-selectin without affecting the binding of PSGL-1 to E-selectin. Rivipansel functionally inhibits the adhesion of hematopoietic cells to endothelial cells, and is applicable to research related to sickle cell disease ^[1] .

HY-122655

HMCEF	P-selectin	Cardiovascular Disease Inflammation/Immunology
HMCEF is an orally active P-selectin inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice ^[1].

HY-P991447

Anti-VSIR/VISTA Antibody (SG7)	VISTA	Cancer
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting VISTA/B7-H5. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P9987A

Crizanlizumab (anti-P-selectin)	P-selectin	Inflammation/Immunology
Crizanlizumab (anti-P-selectin) is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease ^[1] .

HY-P991432

VTX-0811	TNF Receptor NF-κB c-Myc	Cancer
VTX-0811 is a human IgG4 monoclonal antibody (mAb) targeting *PSGL1/CD162. VTX-0811 up-regulates TNF-α/NF-κB* and chemokine-mediated signaling and down-regulates oxidative phosphorylation, fatty acid metabolism, and Myc signaling pathways. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells. VTX-0811 has antitumor activity in a humanized mouse PDX model of melanoma ^[1].

HY-RS12648

SELPLG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SELPLG Human Pre-designed siRNA Set A contains three designed siRNAs for SELPLG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SELPLG Human Pre-designed siRNA Set A SELPLG Human Pre-designed siRNA Set A

HY-RS18203

Selplg Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Selplg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Selplg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Selplg Mouse Pre-designed siRNA Set A Selplg Mouse Pre-designed siRNA Set A

HY-RS24679

Selplg Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Selplg Rat Pre-designed siRNA Set A contains three designed siRNAs for Selplg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Selplg Rat Pre-designed siRNA Set A Selplg Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of *PSGL-1* expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury ^[1] .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9987

Crizanlizumab 1 Publications Verification hSel001; SEG101	P-selectin	Cardiovascular Disease
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease ^[1] .

HY-P99378

Neihulizumab ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab)	Apoptosis	Inflammation/Immunology
Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research ^[1].

HY-P990166

*Anti-Mouse PSGL-1/CD162 Antibody (4RA10)*	Apoptosis Transmembrane Glycoprotein Arenavirus	Infection Inflammation/Immunology
Anti-Mouse PSGL-1/CD162 Antibody (4RA10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse *PSGL-1/CD162. Anti-Mouse PSGL-1/CD162* Antibody (4RA10) blocks PSGL signaling and inhibits leukocyte rolling. Anti-Mouse PSGL-1/CD162 Antibody (4RA10) can be used for the researches of inflammation, immunology and infection, such as pneumonia and lymphocytic choriomeningitis virus infection ^[1] .

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion ^[1] .

HY-P991447

Anti-VSIR/VISTA Antibody (SG7)	VISTA	Cancer
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting VISTA/B7-H5. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P9987A

Crizanlizumab (anti-P-selectin)	P-selectin	Inflammation/Immunology
Crizanlizumab (anti-P-selectin) is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease ^[1] .

HY-P991432

VTX-0811	TNF Receptor NF-κB c-Myc	Cancer
VTX-0811 is a human IgG4 monoclonal antibody (mAb) targeting *PSGL1/CD162. VTX-0811 up-regulates TNF-α/NF-κB* and chemokine-mediated signaling and down-regulates oxidative phosphorylation, fatty acid metabolism, and Myc signaling pathways. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells. VTX-0811 has antitumor activity in a humanized mouse PDX model of melanoma ^[1].

Species:	Human (6) Mouse (3) Cynomolgus (1)
Tag:	His (6) Tag Free (1) Avi (1) Fc (4)
Source:	HEK293 (10)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700815

	*CD162/PSGL-1* Protein, Cynomolgus (HEK293, His)** CLA; PSGL-1; PSGL1; CD162; SELPLG; Selectin P ligand; Selp1; Selpl	Cynomolgus	HEK293
	As a member of the selectin family, CD162/PSGL-1 is mainly expressed in some immune or inflammatory cells. CD162/PSGL-1 deficiency affects myeloid differentiation and lymphocyte maturation and therefore has important implications for cell differentiation. CD162/PSGL-1 can be used as an immune checkpoint modulator and may be a new target for cancer therapy. CD162/PSGL-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700816

	*CD162/PSGL-1* Protein, Mouse (HEK293, His)** CLA; PSGL-1; PSGL1; CD162; SELPLG; Selectin P ligand; Selp1; Selpl	Mouse	HEK293
	The CD162/PSGL-1 protein is an SLe(x)-type proteoglycan that mediates rapid rolling of leukocytes through high-affinity interactions with E- and P-selectin, thereby promoting early inflammatory stages.CD162 forms homodimers linked by disulfide bonds and interacts with selectins through the lectin/EGF domain.CD162/PSGL-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7800

	*CD162/PSGL-1* Protein, Mouse (HEK293, Fc)** rMuCD162, C-Fc; PSGL-1; CD162; SELPLG; CLA;	Mouse	HEK293
	CD162/PSGL-1 Protein, Mouse (HEK293, Fc) is a recombinant mouse CD162 expressed in HEK 293 cells with a C-Fc tag at the C-terminus. CD162/PSGL-1 Protein plays an important role in immunity and homeostasis .

HY-P77165

	*CD162/PSGL-1* Protein, Mouse (HEK293)** P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG	Mouse	HEK293
	The CD162/PSGL-1 protein is an SLe(x)-type proteoglycan that mediates rapid rolling of leukocytes through high-affinity interactions with E- and P-selectin, thereby promoting early inflammatory stages.CD162 forms homodimers linked by disulfide bonds and interacts with selectins through the lectin/EGF domain.CD162/PSGL-1 Protein, Mouse (HEK293) is the recombinant mouse-derived CD162/PSGL-1 protein, expressed by HEK293 , with tag free.

HY-P77164

	*CD162/PSGL-1* Protein, Human (HEK293, mFc)** P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein is a sialomucin expressed on leukocytes, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. CD162/PSGL-1 Protein, Human (HEK293, mFc) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P72485

	*CD162/PSGL-1* Protein, Human (HEK293, hFc)** P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein, a cell surface receptor, plays a crucial role in leukocyte trafficking and adhesion. Dysregulation of CD162/PSGL-1 Protein has been associated with inflammatory diseases and impaired immune responses. Targeting CD162/PSGL-1 Protein may offer potential therapeutic interventions in these conditions by modulating leukocyte trafficking, enhancing immune responses, and managing inflammatory disorders. CD162/PSGL-1 Protein, Human (HEK293, hFc) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77163

	*CD162/PSGL-1* Protein, Human (HEK293, His)** P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein, a cell surface receptor, plays a crucial role in leukocyte trafficking and adhesion. Dysregulation of CD162/PSGL-1 Protein has been associated with inflammatory diseases and impaired immune responses. Targeting CD162/PSGL-1 Protein may offer potential therapeutic interventions in these conditions by modulating leukocyte trafficking, enhancing immune responses, and managing inflammatory disorders. CD162/PSGL-1 Protein, Human (HEK293, His) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77162

	*CD162/PSGL-1* Protein, Human (HEK293, His-Fc)** P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG	Human	HEK293
	CD162/PSGL-1 Protein is a sialomucin expressed on leukocytes, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. CD162/PSGL-1 Protein, Human (HEK293, His-Fc) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His, C-hFc labeled tag.

HY-P705461

	*CD162/PSGL-1* Protein, Human (279a.a, HEK293, His)** P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG	Human	HEK293

HY-P78819

	*CD162/PSGL-1* Protein, Human (Biotinylated, HEK293, His-Avi)** PSGL1; CD162; SELPLG; Selectin P ligand	Human	HEK293
	CD162/PSGL-1 Protein, a cell surface receptor, plays a crucial role in leukocyte trafficking and adhesion. Dysregulation of CD162/PSGL-1 Protein has been associated with inflammatory diseases and impaired immune responses. Targeting CD162/PSGL-1 Protein may offer potential therapeutic interventions in these conditions by modulating leukocyte trafficking, enhancing immune responses, and managing inflammatory disorders. CD162/PSGL-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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Source
Tag
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Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (4)
Application:	IHC-P (3) ICC/IF (1) IP (1) WB (1) FC (2) ELISA (3)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (4) Biotin (1)
Clonality:	Monoclonal (2) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84565

	CD162 Antibody (YA4262) CLA; PSGL1; PSGL-1	IHC-P, FC, ELISA	Human
	CD162 Antibody (YA4262) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD162.

HY-P84565A

	CD162 Antibody (YA4262)(PBS only) CLA; PSGL1; PSGL-1	IHC-P, FC, ELISA	Human
	CD162 Antibody (YA4262) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD162.

HY-P84970

	CD162 Antibody (YA4662) CLA; CD162; PSGL1; PSGL-1; PSGL-1; p-selectin glycoprotein ligand-1; CD 162 antibody; CD162 antibody; CD162 antigen antibody; CLA antibody; Cutaneous lymphocyte associated associated antigen antibody; P selectin glycoprotein ligand 1 antibody; P selectin glycoprotein ligand 1 precursor antibody; P-selectin glycoprotein ligand 1 antibody; PSGL 1 antibody; PSGL-1 antibody; PSGL1 antibody; Selectin P ligand antibody; SELPL_HUMAN antibody; SELPLG antibody;	ELISA	Human
	CD162 Antibody (YA4662) is a non-conjugated antibody, targeting to CD162.

HY-P81711

	CD162 Antibody (YA1456) CD162; CLA; PSGL1; SELPLG	WB, IHC-P, ICC/IF, IP	Human
	CD162 Antibody (YA1456) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD162.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS12648

SELPLG Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SELPLG Human Pre-designed siRNA Set A contains three designed siRNAs for SELPLG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18203

Selplg Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Selplg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Selplg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24679

Selplg Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Selplg Rat Pre-designed siRNA Set A contains three designed siRNAs for Selplg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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