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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
RGS Protein
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "RGS Protein" in MCE Product Catalog:
2
2 Cited Publications
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CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .
Cat. No.: HY-U00431
CAS No.: 410074-60-1
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CCG 203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM.
Cat. No.: HY-175763
CAS No.: 865271-09-6
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Z55660043 is a Regulator of G protein signaling-14 (RGS14) inhibitor with an IC50 of 2.3 μM. Z55660043 selectively and non-covalently inhibits RGS14 GTPase-accelerating protein (GAP) activity without measurable cytotoxicity. Z55660043 can be used for central nervous system and metabolic disorders research .
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BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux .
Cat. No.: HY-171251
CAS No.: 1113116-62-3
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RGS10 modulator-1 (compound 15) is a potent RGS10 modulator. RGS10 modulator-1 significantly reverses IFNγ-induced RGS10 protein and mRNA expression. RGS10 modulator-1 reverse the IFNγ-induced COX-2 mRNA and iNOS expression .
Cat. No.: HY-13509R
CAS No.: 883050-24-6
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CCG-50014 (Standard) is the analytical standard of CCG-50014. This product is intended for research and analytical applications. CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .
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CCG-4986 is an RGS protein inhibitor. CCG-4986 inhibits protein activity by covalently modifying the Cys-132 site of RGS4. CCG-4986 can be used to study diseases related to dysregulated G protein-coupled receptor (GPCR) signaling, such as Parkinson's disease and opioid addiction .
Cat. No.: HY-P701398
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RGS14; Regulator of G-Protein signaling 14; RGS14
Cat. No.: HY-P701399
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RGS14; Regulator of G-Protein signaling 14; RGS14
Cat. No.: HY-P700384
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RGS17; RGSZ2; RGS-17; hRGS17; regulator of G-Protein signaling 17; OTTHUMP00000017460
Cat. No.: HY-P702984
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: 1R20; BL34; IER1
Cat. No.: HY-145457
CAS No.: 172679-58-2
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RS-23597 is a 5-HT4R antagonist with a Ki value of 19 nM against guinea pig 5-HT4R. RS-23597 inhibits the relaxation of the esophageal muscularis mucosae in rats. RS-23597 regulates 5-HT4R-Gs protein coupling and triggers the Gs-mediated cAMP signaling pathway. RS-23597 is applicable to the research of neurological diseases .
Cat. No.: HY-P83466A
Synonyms: regulator of G Protein signaling 6; GAP; S914; HA117
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
