1 Result for "

Ruminococcus torques

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Ruminococcus torques" in MCE Product Catalog:

Mevalonolactone
Mevalonolactone
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Cat. No.: HY-135700
CAS No.: 19115-49-2
Purity:  ≥98.0%
Category:  

Microorganisms Other Phenylpropanoids Phenylpropanoids

Target:  

Calcineurin Ras HMG-CoA Reductase (HMGCR)

Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (Ka = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .
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