Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
SAMHD1
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "SAMHD1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-B1299A
CAS No.: 59143-60-1
Target:
Research Areas:
Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM [1]. Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity .
Cat. No.: HY-161296
TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe [1].
Cat. No.: HY-RS12433
Target:
Research Areas:
SAMHD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SAMHD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182973
Research Areas:
SAMHD1 ligand-1 is a SAMHD1 ligand that can be used for the synthesis of PROTAC SAMHD1 Degrader-1 (HY-182970) [1].
Cat. No.: HY-182970
Target:
Research Areas:
PROTAC SAMHD1 Degrader-1 is an orally active targeted SAMHD1 PROTAC degrader, with an IC50 of 6.3 μM against the dNTP hydrolase activity of SAMHD1. PROTAC SAMHD1 Degrader-1 binds to SAMHD1 inside cells and mediates its degradation, with low off-target effects. PROTAC SAMHD1 Degrader-1 inhibits the production of pro-inflammatory cytokines and interferes with the cascade amplification process of inflammatory responses. PROTAC SAMHD1 Degrader-1 delays the progression of pulmonary fibrosis and exerts protective effects on lung tissues. PROTAC SAMHD1 Degrader-1 can be used in pulmonary fibrosis-related research [1].
Cat. No.: HY-RS17783
Target:
Research Areas:
Samhd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Samhd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24250
Target:
Research Areas:
Samhd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Samhd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-137613
CAS No.: 83199-32-0
Target:
Research Areas:
Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS competitively inhibits SAMHD1 triphosphohydrolase activity with a Ki value of 46 µM [1].
Cat. No.: HY-137618B
CAS No.: 80902-29-0
Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates [1].
Cat. No.: HY-137613A
Target:
Research Areas:
Sp-TTPαS tetrasodium is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS tetrasodium competitively inhibits SAMHD1 triphosphohydrolase activity with a Ki value of 46 µM [1].
Cat. No.: HY-137618A
Target:
Research Areas:
Sp-dGTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616). Sp-dGTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a Ki of 820 nM [1].
Cat. No.: HY-137619A
Target:
Research Areas:
Sp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616). Sp-dCTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a Ki of 6.3 μM [1].
Cat. No.: HY-182974
CAS No.: 3033533-52-4
Target:
Research Areas:
DCAF1 binder 3 is a DCAF1 binder and an E3 ligase ligand. DCAF1 binder 3 can be used to synthesize PROTAC SAMHD1 Degrader-1 (HY-182970) [1].
Cat. No.: HY-182975
Research Areas:
E3 Ligase Ligand-linker Conjugate 229 is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTAC SAMHD1 Degrader-1 (HY-182970) [1].
Cat. No.: HY-P703313
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MOP5
Species:
Source:
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
