25 Results for "

SIRT1-IN-1

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "SIRT1-IN-1" in MCE Product Catalog:

2
SIRT1-IN-1
SIRT1-IN-1
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2 Cited Publications
Cat. No.: HY-136199
CAS No.: 352554-02-0
Purity:  98.15%
Target:  

Sirtuin CMV

Research Areas:  

Infection

SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM . SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity .
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174
Resveratrol
Resveratrol
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174 Publications Verification
Cat. No.: HY-16561
CAS No.: 501-36-0
Synonyms: trans-Resveratrol; SRT501
Category:  

Anti-aging Vitis vinifera cv. Zalema Plants Vitaceae Infection Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer

Target:  

DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2

Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
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2
(+)-Magnoflorine chloride
(+)-Magnoflorine chloride
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2 Cited Publications
Cat. No.: HY-N0535
CAS No.: 6681-18-1
Synonyms: MagnoflorINe chloride; α-MagnoflorINe chloride; ThalictrINe chloride
Category:  

Metabolic Disease Plants Aristolochiaceae Infection Alkaloids Piperidine Alkaloids other families Aristolochia debilis Sieb. et Zucc. Phenols Polyphenols Disease Research Fields

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) chloride is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine chloride promotes Parkin/PINK1-mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine chloride inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine chloride upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine chloride also has significant antifungal activity .
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2
(+)-Magnoflorine iodide
(+)-Magnoflorine iodide
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2 Cited Publications
Cat. No.: HY-N0334A
CAS No.: 4277-43-4
Synonyms: MagnoflorINe iodide; α-MagnoflorINe iodide; ThalictrINe iodide
Category:  

Alkaloids Magnoliaceae Metabolic Disease Phenols Polyphenols Magnolia Liliflora Desr. Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine iodide promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine iodide inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine iodide also has significant antifungal activity .
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1
Scopolin
Scopolin
0 Images
1 Cited Publications
Cat. No.: HY-N0341
CAS No.: 531-44-2
Category:  

Anisodus tanguticus (Maxinowicz) Pascher Metabolic Disease Coumarins Arabidopsis thaliana Phenylpropanoids Plants Solanaceae Brassicaceae Disease Research Fields

Target:  

Sirtuin

Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .
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1
4-Hydroxyestrone
4-Hydroxyestrone
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1 Cited Publications
Cat. No.: HY-W009300
CAS No.: 3131-23-5
Synonyms: 4-OHE1
Category:  

Neurological Disease Animals Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)

4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .
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Resveratrol (Standard)
Resveratrol (Standard)
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Cat. No.: HY-16561R
CAS No.: 501-36-0
Synonyms: trans-Resveratrol (Standard); SRT501 (Standard)
Category:  

Infection Functional Molecules Anti-aging Sunscreen Research of Health Products Cosmetic Research Plants Disease Research Fields Inflammation/Immunology Cancer

Target:  

Reference Standards IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2

Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
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(+)-Magnoflorine
(+)-Magnoflorine
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Cat. No.: HY-N0334
CAS No.: 2141-09-5
Synonyms: MagnoflorINe; α-MagnoflorINe; ThalictrINe
Category:  

Alkaloids Ranunculaceae Coptis chinensis Franch. Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine also has significant antifungal activity .
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Perfluorotetradecanoic acid
Perfluorotetradecanoic acid
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Cat. No.: HY-W073128
CAS No.: 376-06-7
Synonyms: PFTeDA
Target:  

PPAR Apoptosis PGC-1α AMPK Akt mTOR Reactive Oxygen Species (ROS)

Research Areas:  

Endocrinology

Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a Kd value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats .
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Resveratrol-d4
Resveratrol-d4
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Cat. No.: HY-16561S
CAS No.: 1089051-56-8
Synonyms: trans-Resveratrol-d4; SRT501-d4
Resveratrol-d4 is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
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Arjunolic acid
Arjunolic acid
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Cat. No.: HY-N2896
CAS No.: 465-00-9
Category:  

Triterpenes Juglandaceae Terpenoids Cyclocarya paliurus (Batal.) Iljinsk. Plants Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers Reactive Oxygen Species (ROS) Apoptosis Fungal Bacterial NF-κB SOD AMPK mTOR Notch Toll-like Receptor (TLR) Wnt MyD88 Sirtuin

Arjunolic acid is an orally active, multifunctional bioactive compound. Arjunolic acid exhibits free radical scavenging activity, as well as fungal and bacterial activities. Arjunolic acid induces apoptosis (Apoptosis) in various cancer cells. Arjunolic acid protects hepatocytes against induced oxidative stress and apoptosis by reducing reactive oxygen species and inhibiting NF-κB activation. Arjunolic acid regulates pancreatic dysfunction in type 2 diabetic rats by blocking the activation of the TLR-4/MyD88 and canonical Wnt pathways. Arjunolic acid inhibits neuroinflammation and ameliorates depressive behaviors via the SIRT1/AMPK/Notch1 signaling pathway in microglia. Arjunolic acid improves Crohn's disease-like colitis by restoring gut microbiota composition and inhibiting TLR4 signaling. Arjunolic acid suppresses osteosarcoma progression by inhibiting Wnt3a-mediated M2 polarization of macrophages. Arjunolic acid ameliorates diabetic retinopathy via the autophagy pathway regulated by AMPK/mTOR/HO-1. Arjunolic acid is applicable to research related to type 2 diabetes, organ toxicity, depression, Crohn's disease, osteosarcoma, diabetic retinopathy, and testicular dysfunction .
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Cannabisin F
Cannabisin F
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Cat. No.: HY-N3532
CAS No.: 163136-19-4
Category:  

Monophenols Phenols Plants Solanaceae Datura metel Linn.

Target:  

Sirtuin

Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2 .
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Resveratrol (GMP)
Resveratrol (GMP)
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Cat. No.: HY-16561G
CAS No.: 501-36-0
Synonyms: trans-Resveratrol (GMP); SRT501 (GMP)
Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
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SIRT1 activator 1
SIRT1 activator 1
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Cat. No.: HY-N12386
Category:  

Microorganisms Ketones, Aldehydes, Acids Marine natural products Marine microorganism

Target:  

Sirtuin

SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway .
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BF-175
BF-175
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Cat. No.: HY-138443A
CAS No.: 1333375-02-2
Target:  

Sirtuin PGC-1α Apoptosis Autophagy Fatty Acid Synthase (FASN)

Research Areas:  

Metabolic Disease Cancer

BF-175 is a selective SIRT1 agonist. BF175 increases SIRT1-mediated activation of PGC1-α, induces Apoptosis, induces Autophagy and inhibits SREBP activity. BF-175 protects against high glucose-mediated mitochondrial injury. BF-175 attenuates diabetic kidney disease progression. BF175 inhibits endometrial carcinoma .
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Resveratrol-13C6
Resveratrol-13C6
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Cat. No.: HY-16561S1
Synonyms: trans-Resveratrol-13C6; SRT501-13C6
Resveratrol- 13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
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LDH-IN-3
LDH-IN-3
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Cat. No.: HY-168172
Target:  

Lactate Dehydrogenase

Research Areas:  

Cancer

LDH-IN-3 (compound E38) is an inhibitor of LDH, promising protective agent for ischemic nerve damage in the eye and brain. LDH-IN-3 acts its function via HO-1/SIRT1 pathway. .
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Scopolin (Standard)
Scopolin (Standard)
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Cat. No.: HY-N0341R
CAS No.: 531-44-2
Category:  

Anisodus tanguticus (Maxinowicz) Pascher Coumarins Arabidopsis thaliana Phenylpropanoids Plants Solanaceae Brassicaceae

Target:  

Reference Standards Sirtuin

Scopolin (Standard) is the analytical standard of Scopolin. This product is intended for research and analytical applications. Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .
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4-Hydroxyestrone-d4
4-Hydroxyestrone-d4
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Cat. No.: HY-W009300S
CAS No.: 81586-98-3
Synonyms: 4-OHE1-d4
4-Hydroxyestrone (4-OHE1)-d4 is the deuterium labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .
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