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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
SST5
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "SST5" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-P1202
CAS No.: 183658-72-2
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3
3 Cited Publications
Cat. No.: HY-P1202A
CAS No.: 2828432-46-6
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1
1 Cited Publications
Cat. No.: HY-P1932
CAS No.: 186901-48-4
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1 Cited Publications
Cat. No.: HY-P1206
CAS No.: 174688-78-9
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CH 275 is a peptidic somatostatin analog that acts as an agonist of SST1 (IC50 = 30.9 nM, Ki = 52 nM). The IC50 values of CH 275 for sst3, sst4, sst2, and sst5 are 345 nM, >1 μM, >10 μM, and >10 μM, respectively. CH 275 binds to SSTR1 via the IAmp9-Asp137 ion pair interaction and the hydrophobic interaction between the isopropyl group of IAmp9 and Leu107, and reduces the extracellular acidification rate. CH 275 induces weak sst1 internalization, exerts immunosuppressive effects on macrophages, and decreases macrophage viability, MCP-1 expression/secretion, and IL-8 secretion, but does not alter proMMP-9 secretion or IL-8 mRNA levels. CH 275 reduces hippocampal β-amyloid levels and alleviates plaque pathology without inducing hippocampal microglial activation. CH 275 is used in research on Alzheimer's disease, Parkinson's disease, and depression [5].
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1 Cited Publications
Cat. No.: HY-P1932A
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Cat. No.: HY-P1203
CAS No.: 150155-61-6
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Cat. No.: HY-P4469
CAS No.: 341519-04-8
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Cat. No.: HY-P2090A
CAS No.: 2478421-60-0
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Cat. No.: HY-164040
CAS No.: 2604416-66-0
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Zavolosotine (Compound 1) is an orally active agonist for somatostatin receptor type 5 (SST5) with EC50 <1 nM. Zavolosotine inhibits insulin and glucagon secretion, increases levels of glucagon in blood in rat model .
Cat. No.: HY-P1203A
CAS No.: 1426173-61-6
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Cat. No.: HY-P2090
CAS No.: 113294-82-9
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Cat. No.: HY-RS13832
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SSTR5 Human Pre-designed siRNA Set A contains three designed siRNAs for SSTR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS13833
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Sstr5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sstr5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
