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Results for "

Sennoside

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

13

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0365
    Sennoside A
    Maximum Cited Publications
    6 Publications Verification

    		 DNA/RNA Synthesis HIV Infection
    Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC50=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC50s of 1.9 μM and 5.3 μM, respectively .
    Sennoside A
  • HY-N0366
    Sennoside B
    3 Publications Verification

    		 PDGFR Inflammation/Immunology
    Sennoside B is a potent and orally active platelet-derived growth factor (PDGF) inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis .
    Sennoside B
  • HY-N1972
    Sennoside C

    		Others Neurological Disease Metabolic Disease
    Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases .
    Sennoside C
  • HY-N6082
    Rhein 8-O-β-D-Glucopyranoside
    1 Publications Verification

    		 Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial Infection Metabolic Disease Inflammation/Immunology
    Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .
    Rhein 8-O-β-D-Glucopyranoside
  • HY-N1973
    Sennoside D

    		Others Infection Inflammation/Immunology
    Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia) .
    Sennoside D
  • HY-N12281
    Sennoside

    		Apoptosis MDM-2/p53 PAK Calcium Channel Endocrinology Cancer
    Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna (Cassia angustifolia). Sennoside induces overexpression of wild-type p53 and p21/WAF as part of pathways mediating colonic epithelial cell apoptosis. Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli, and colorectal cancer .
    Sennoside
  • HY-N0365R
    Sennoside A (Standard)
    Maximum Cited Publications
    6 Publications Verification

    		 Reference Standards HIV Infection
    Sennoside A (Standard) is the analytical standard of Sennoside A. This product is intended for research and analytical applications. Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia) . Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication .
    Sennoside A (Standard)
  • HY-N0366R
    Sennoside B (Standard)

    		Reference Standards PDGFR Cancer
    Sennoside B (Standard) is the analytical standard of Sennoside B. This product is intended for research and analytical applications. Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia) . Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway .
    Sennoside B (Standard)
  • HY-N1972R
    Sennoside C (Standard)

    		Reference Standards Others Neurological Disease Metabolic Disease
    Sennoside C (Standard) is the analytical standard of Sennoside C (HY-N1972). This product is intended for research and analytical applications. Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases .
    Sennoside C (Standard)
  • HY-N1973R
    Sennoside D (Standard)

    		Reference Standards Others Infection Inflammation/Immunology
    Sennoside D (Standard) is the analytical standard of Sennoside D. This product is intended for research and analytical applications. Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia) .
    Sennoside D (Standard)
  • HY-N6082R
    Rhein 8-O-β-D-Glucopyranoside (Standard)

    		Reference Standards Apoptosis Bacterial Bcl-2 Family Caspase TGF-beta/Smad Infection Metabolic Disease Inflammation/Immunology
    Rhein 8-O-β-D-Glucopyranoside (Standard) is the analytical standard of Rhein 8-O-β-D-Glucopyranoside (HY-N6083). This product is intended for research and analytical applications. Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .
    Rhein 8-O-β-D-Glucopyranoside (Standard)
  • HY-N18652
    Senna extract

    		Bacterial Infection Inflammation/Immunology
    Senna extract contains anthraquinone compounds, such as sennosides A and B, which have laxative properties. Sennosides in senna extract can stimulate colon muscles, promote intestinal peristalsis, and relieve constipation.
    Senna extract
  • HY-N18716
    Senna leaf extract

    		Others Others
    Senna Leaf Extract is the main raw material of Cassia angustifolia Vahl. Its main active ingredients are Sennoside A and B, and contain rhein, aloe-emodin, chrysophanol and other anthraquinones Derivatives and other glycosides.
    Senna leaf extract

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